C4LAK4 (GSA_TOLAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	Tola_0579

Organism

Tolumonas auensis (strain DSM 9187 / TA4) [Complete proteome] [HAMAP]

Taxonomic identifier

595494 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Tolumonas › Tolumonas auensis

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375		PRO_0000382389
Amino acid modifications
	Modified residue	269	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	C4LAK4 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: ABDFFCAD43534A12	FASTA	431	45,845
	10 20 30 40 50 60 MAYSTQRSEQ LFTAAQQSIP GGVNSPVRAF NGVGGTPRFI AKADGAYLFD VDGNRYIDYV 70 80 90 100 110 120 GSWGPMLLGH NHPAIKAAVL AAVENGLSYG APTESEVLMA EMIRQIMPDM EMVRMVNSGT 130 140 150 160 170 180 EATMSAIRLA RGYTGRDKIV KFEGCYHGHA DCLLVKAGSG ALTLGQPNSP GVPADFAKHT 190 200 210 220 230 240 LTCTYNDLAS VEATFASYGS EIACIIVEPV AGNMNCIPPV PGFLEGLRAI CDKYGALLII 250 260 270 280 290 300 DEVMTGFRVS LQGAQGYYGI TPDLTTLGKI IGGGMPVGAF GGKKEIMAYI APTGPVYQAG 310 320 330 340 350 360 TLSGNPVAMA AGLAMLKAIQ QPGLYDTLAE KTRQVAEGLK AAAAKQGIPL TVNYVGAMFG 370 380 390 400 410 420 FFFTDEPEIT RFEQVSRCDI DAFRRFYHLM LQEGVYLAPS AYEAGFLSLA HSEADIAETL 430 AAAERCFAQM K

References

[1]

"Complete sequence of Tolumonas auensis DSM 9187." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Spring S., Beller H. Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 9187 / TA4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001616 Genomic DNA. Translation: ACQ92208.1.
RefSeq	YP_002891794.1. NC_012691.1.
3D structure databases
ProteinModelPortal	C4LAK4.
ModBase	Search...
Protein-protein interaction databases
STRING	595494.Tola_0579.
Proteomic databases
PRIDE	C4LAK4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACQ92208; ACQ92208; Tola_0579.
GeneID	7886444.
KEGG	tau:Tola_0579.
PATRIC	23977759. VBITolAue42623_0581.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
ProtClustDB	PRK00062.
Enzyme and pathway databases
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_TOLAT

Accession

Primary (citable) accession number: C4LAK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program