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C4LA41

- PUR9_TOLAT

UniProt

C4LA41 - PUR9_TOLAT

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Tola_0541
Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-564-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Tola_0541
OrganismiTolumonas auensis (strain DSM 9187 / TA4)
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
ProteomesiUP000009073: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000203255Add
BLAST

Proteomic databases

PRIDEiC4LA41.

Interactioni

Protein-protein interaction databases

STRINGi595494.Tola_0541.

Structurei

3D structure databases

ProteinModelPortaliC4LA41.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

C4LA41-1 [UniParc]FASTAAdd to Basket

« Hide

MENARPIRRA LLSVSDKTGI VEFARALQQR GVELLSTGGT ARLLADAGLA    50
VTEVSDYTGF PEMMDGRVKT LHPKVHGGIL GRRNTDDAIM TQHGIKPIDL 100
VAVNLYPFAA TVANPDCALE DAIENIDIGG PTMVRSAAKN HKDVTIVVNA 150
KDYTRVLAEM DANANSLTYT TRFDLAIAAF EHTAAYDGMI ANYFGTKVPT 200
YGVQDEASAD SKFPRTINFQ FIKKQDMRYG ENSHQAAAFY VEADVKEASV 250
STATQLQGKA LSYNNIADTD AALECVKEFA EPACVIVKHA NPCGVALGND 300
ILEAYNRAYQ TDPTSAFGGI IAFNRELDAA TAEAIVSRQF VEVIIAPVVS 350
EEAKAVVAKK ANVRLLECGQ WQGKANGFDV KRVNGGLLVQ DRDQGMVTLT 400
DLKVVTKRQP TEQELKDLLF CWKVGKFVKS NAIVYAKDSM TIGVGAGQMS 450
RVYSAKIAGI KAADEGLEVK GSVMASDAFF PFRDGIDAAA EAGITCVIQP 500
GGSMRDQEVI DAADEHGMAM VFTNMRHFRH 530
Length:530
Mass (Da):57,280
Last modified:July 7, 2009 - v1
Checksum:i666614F6C764A14B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001616 Genomic DNA. Translation: ACQ92170.1.
RefSeqiYP_002891756.1. NC_012691.1.

Genome annotation databases

EnsemblBacteriaiACQ92170; ACQ92170; Tola_0541.
GeneIDi7883356.
KEGGitau:Tola_0541.
PATRICi23977685. VBITolAue42623_0545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001616 Genomic DNA. Translation: ACQ92170.1 .
RefSeqi YP_002891756.1. NC_012691.1.

3D structure databases

ProteinModelPortali C4LA41.
ModBasei Search...

Protein-protein interaction databases

STRINGi 595494.Tola_0541.

Proteomic databases

PRIDEi C4LA41.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ92170 ; ACQ92170 ; Tola_0541 .
GeneIDi 7883356.
KEGGi tau:Tola_0541.
PATRICi 23977685. VBITolAue42623_0545.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci TAUE595494:GHEF-564-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9187 / TA4.

Entry informationi

Entry nameiPUR9_TOLAT
AccessioniPrimary (citable) accession number: C4LA41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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