C4L9L6 (APAH_TOLAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	Tola_2372

Organism

Tolumonas auensis (strain DSM 9187 / TA4) [Complete proteome] [HAMAP]

Taxonomic identifier

595494 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Tolumonas › Tolumonas auensis

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP-Rule MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP-Rule MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP-Rule MF_00199		PRO_1000204090

Sequences

	Sequence		Length	Mass (Da)
	C4L9L6 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: 582BDD4D2FD89EC4	FASTA	276	31,187
	10 20 30 40 50 60 MATYFVGDIQ GCNDELQQLL ALAQFNPQHD ELWLTGDLVA RGPKSLDVLR FVYGLGDRAT 70 80 90 100 110 120 TVLGNHDLNL LAVDAGYSQA KKKDKTENIL TAPDRHELMT WLRTQPIMAE HPTLPVMMTH 130 140 150 160 170 180 AGLSPQWDLA TARHCAREVE MLLRSDQGNW LLGHMYGEEP SHWDARLTGL PRWRYIINSF 190 200 210 220 230 240 TRMRFCRNDG SLEFKCKEAP SDKPALLAPW FEVRQAAPDE PHLVFGHWAA LMGKCPLPTI 250 260 270 KALDTGCVWG NQLTLWRWDD NAMFSLNCPA YASGGE

References

[1]

"Complete sequence of Tolumonas auensis DSM 9187." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Spring S., Beller H. Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 9187 / TA4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001616 Genomic DNA. Translation: ACQ93969.1.
RefSeq	YP_002893555.1. NC_012691.1.
3D structure databases
ProteinModelPortal	C4L9L6.
ModBase	Search...
Protein-protein interaction databases
STRING	595494.Tola_2372.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACQ93969; ACQ93969; Tola_2372.
GeneID	7886309.
KEGG	tau:Tola_2372.
PATRIC	23981407. VBITolAue42623_2356.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HOG000251871.
KO	K01525.
ProtClustDB	PRK00166.
Family and domain databases
HAMAP	MF_00199. ApaH.
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_TOLAT

Accession

Primary (citable) accession number: C4L9L6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program