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C4L9A9

- SPEA_TOLAT

UniProt

C4L9A9 - SPEA_TOLAT

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Protein
Biosynthetic arginine decarboxylase
Gene
speA, Tola_0379
Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-401-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:Tola_0379
OrganismiTolumonas auensis (strain DSM 9187 / TA4)
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
ProteomesiUP000009073: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Biosynthetic arginine decarboxylaseUniRule annotation
PRO_1000215249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei101 – 1011N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi595494.Tola_0379.

Structurei

3D structure databases

ProteinModelPortaliC4L9A9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni284 – 29411Substrate-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4L9A9-1 [UniParc]FASTAAdd to Basket

« Hide

MANWSCQDAL KMYNVPYWGA GFFNIDALGR VVVTPDKTRL DCKIALVDII    50
EQLRKQGYAT PVLLRFPDII KTRINALFGA FEQAIQSYGY KGRYQCVYPI 100
KVNQQNQVIE SVTRAFADKP ALGLEAGSKP ELLAVLSHHH DLGSVIVCNG 150
YKDREYVRHA LLGSLLGHHV YIVVEKPSEL ELILDEAARL NITPRIGVRA 200
RLASQGSGKW QASGGEKSKF GLNAAQILRL VERLREADKL DCLQLVHFHL 250
GSQIANIRDI QGGIRECGRF YAELRHLGAN IEVVDVGGGL GVDYEGSRSQ 300
SHCSANYNLR EYANNVVWGI GDVCAEFDLP HPMIISESGR AITAHHAVLI 350
SNIVGMESQL PTSLPDAPDA EAPMLLQNMW DSWKELHEKE DPGLLEIFHD 400
SVSDLADVHT QYTLGMLSLH QRAWAEDLHL NLCLKLKVML DPVNRMHRNL 450
QDELNEKLAD KCFVNFSLFQ SLPDAWGIDQ IFPIMPLSGL DQQPTRRGVI 500
MDITCDSDGM IKEYVDGVGI ENSLPMPEMR NDETNYMGFF LVGAYQEILG 550
DLHNLFGDTH SAEVCLNDNG EPVITNIIKG DNVDNLLRYV NIDTSVIRRD 600
YQKLVAHPSL SEETRKALLE ELEAGLQGYA YLEDE 635
Length:635
Mass (Da):71,044
Last modified:July 7, 2009 - v1
Checksum:iA0481E9AB54B7E4E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001616 Genomic DNA. Translation: ACQ92008.1.
RefSeqiWP_012728607.1. NC_012691.1.
YP_002891594.1. NC_012691.1.

Genome annotation databases

EnsemblBacteriaiACQ92008; ACQ92008; Tola_0379.
GeneIDi7884195.
KEGGitau:Tola_0379.
PATRICi23977365. VBITolAue42623_0385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001616 Genomic DNA. Translation: ACQ92008.1 .
RefSeqi WP_012728607.1. NC_012691.1.
YP_002891594.1. NC_012691.1.

3D structure databases

ProteinModelPortali C4L9A9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 595494.Tola_0379.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ92008 ; ACQ92008 ; Tola_0379 .
GeneIDi 7884195.
KEGGi tau:Tola_0379.
PATRICi 23977365. VBITolAue42623_0385.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci TAUE595494:GHEF-401-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9187 / TA4.

Entry informationi

Entry nameiSPEA_TOLAT
AccessioniPrimary (citable) accession number: C4L9A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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