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C4L9A9

- SPEA_TOLAT

UniProt

C4L9A9 - SPEA_TOLAT

Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

    Catalytic activityi

    L-arginine = agmatine + CO2.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation
    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciTAUE595494:GHEF-401-MONOMER.
    UniPathwayiUPA00186; UER00284.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
    Short name:
    ADCUniRule annotation
    Gene namesi
    Name:speAUniRule annotation
    Ordered Locus Names:Tola_0379
    OrganismiTolumonas auensis (strain DSM 9187 / TA4)
    Taxonomic identifieri595494 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
    ProteomesiUP000009073: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 635635Biosynthetic arginine decarboxylasePRO_1000215249Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei101 – 1011N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi595494.Tola_0379.

    Structurei

    3D structure databases

    ProteinModelPortaliC4L9A9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni284 – 29411Substrate-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiIDHYVDG.
    OrthoDBiEOG676Z0R.

    Family and domain databases

    Gene3Di2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.
    PROSITEiPS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4L9A9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANWSCQDAL KMYNVPYWGA GFFNIDALGR VVVTPDKTRL DCKIALVDII    50
    EQLRKQGYAT PVLLRFPDII KTRINALFGA FEQAIQSYGY KGRYQCVYPI 100
    KVNQQNQVIE SVTRAFADKP ALGLEAGSKP ELLAVLSHHH DLGSVIVCNG 150
    YKDREYVRHA LLGSLLGHHV YIVVEKPSEL ELILDEAARL NITPRIGVRA 200
    RLASQGSGKW QASGGEKSKF GLNAAQILRL VERLREADKL DCLQLVHFHL 250
    GSQIANIRDI QGGIRECGRF YAELRHLGAN IEVVDVGGGL GVDYEGSRSQ 300
    SHCSANYNLR EYANNVVWGI GDVCAEFDLP HPMIISESGR AITAHHAVLI 350
    SNIVGMESQL PTSLPDAPDA EAPMLLQNMW DSWKELHEKE DPGLLEIFHD 400
    SVSDLADVHT QYTLGMLSLH QRAWAEDLHL NLCLKLKVML DPVNRMHRNL 450
    QDELNEKLAD KCFVNFSLFQ SLPDAWGIDQ IFPIMPLSGL DQQPTRRGVI 500
    MDITCDSDGM IKEYVDGVGI ENSLPMPEMR NDETNYMGFF LVGAYQEILG 550
    DLHNLFGDTH SAEVCLNDNG EPVITNIIKG DNVDNLLRYV NIDTSVIRRD 600
    YQKLVAHPSL SEETRKALLE ELEAGLQGYA YLEDE 635
    Length:635
    Mass (Da):71,044
    Last modified:July 7, 2009 - v1
    Checksum:iA0481E9AB54B7E4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001616 Genomic DNA. Translation: ACQ92008.1.
    RefSeqiWP_012728607.1. NC_012691.1.
    YP_002891594.1. NC_012691.1.

    Genome annotation databases

    EnsemblBacteriaiACQ92008; ACQ92008; Tola_0379.
    GeneIDi7884195.
    KEGGitau:Tola_0379.
    PATRICi23977365. VBITolAue42623_0385.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001616 Genomic DNA. Translation: ACQ92008.1 .
    RefSeqi WP_012728607.1. NC_012691.1.
    YP_002891594.1. NC_012691.1.

    3D structure databases

    ProteinModelPortali C4L9A9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 595494.Tola_0379.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ92008 ; ACQ92008 ; Tola_0379 .
    GeneIDi 7884195.
    KEGGi tau:Tola_0379.
    PATRICi 23977365. VBITolAue42623_0385.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi IDHYVDG.
    OrthoDBi EOG676Z0R.

    Enzyme and pathway databases

    UniPathwayi UPA00186 ; UER00284 .
    BioCyci TAUE595494:GHEF-401-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    PROSITEi PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 9187 / TA4.

    Entry informationi

    Entry nameiSPEA_TOLAT
    AccessioniPrimary (citable) accession number: C4L9A9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3