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C4L9A9 (SPEA_TOLAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Tola_0379
OrganismTolumonas auensis (strain DSM 9187 / TA4) [Complete proteome] [HAMAP]
Taxonomic identifier595494 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000215249

Regions

Region284 – 29411Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
C4L9A9 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: A0481E9AB54B7E4E

FASTA63571,044
        10         20         30         40         50         60 
MANWSCQDAL KMYNVPYWGA GFFNIDALGR VVVTPDKTRL DCKIALVDII EQLRKQGYAT 

        70         80         90        100        110        120 
PVLLRFPDII KTRINALFGA FEQAIQSYGY KGRYQCVYPI KVNQQNQVIE SVTRAFADKP 

       130        140        150        160        170        180 
ALGLEAGSKP ELLAVLSHHH DLGSVIVCNG YKDREYVRHA LLGSLLGHHV YIVVEKPSEL 

       190        200        210        220        230        240 
ELILDEAARL NITPRIGVRA RLASQGSGKW QASGGEKSKF GLNAAQILRL VERLREADKL 

       250        260        270        280        290        300 
DCLQLVHFHL GSQIANIRDI QGGIRECGRF YAELRHLGAN IEVVDVGGGL GVDYEGSRSQ 

       310        320        330        340        350        360 
SHCSANYNLR EYANNVVWGI GDVCAEFDLP HPMIISESGR AITAHHAVLI SNIVGMESQL 

       370        380        390        400        410        420 
PTSLPDAPDA EAPMLLQNMW DSWKELHEKE DPGLLEIFHD SVSDLADVHT QYTLGMLSLH 

       430        440        450        460        470        480 
QRAWAEDLHL NLCLKLKVML DPVNRMHRNL QDELNEKLAD KCFVNFSLFQ SLPDAWGIDQ 

       490        500        510        520        530        540 
IFPIMPLSGL DQQPTRRGVI MDITCDSDGM IKEYVDGVGI ENSLPMPEMR NDETNYMGFF 

       550        560        570        580        590        600 
LVGAYQEILG DLHNLFGDTH SAEVCLNDNG EPVITNIIKG DNVDNLLRYV NIDTSVIRRD 

       610        620        630 
YQKLVAHPSL SEETRKALLE ELEAGLQGYA YLEDE 

« Hide

References

[1]"Complete sequence of Tolumonas auensis DSM 9187."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Spring S., Beller H.
Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 9187 / TA4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001616 Genomic DNA. Translation: ACQ92008.1.
RefSeqYP_002891594.1. NC_012691.1.

3D structure databases

ProteinModelPortalC4L9A9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING595494.Tola_0379.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ92008; ACQ92008; Tola_0379.
GeneID7884195.
KEGGtau:Tola_0379.
PATRIC23977365. VBITolAue42623_0385.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAMIHFHIG.
OrthoDBEOG676Z0R.
ProtClustDBPRK05354.

Enzyme and pathway databases

BioCycTAUE595494:GHEF-401-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_TOLAT
AccessionPrimary (citable) accession number: C4L9A9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways