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C4L950

- C4L950_TOLAT

UniProt

C4L950 - C4L950_TOLAT

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Protein

Isocitrate dehydrogenase [NADP]

Gene
Tola_2323
Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-2398-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Tola_2323Imported
OrganismiTolumonas auensis (strain DSM 9187 / TA4)Imported
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
ProteomesiUP000009073: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi595494.Tola_2323.

Structurei

3D structure databases

ProteinModelPortaliC4L950.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4L950-1 [UniParc]FASTAAdd to Basket

« Hide

MESKIVVPAT GEKISVDAAG KLVVPNNPII PFIEGDGIGV DVTPAMLKVV    50
DAAVEKAYKG EKKISWMEIY TGEKSTKIYG DDVWLPAETM DAMREYHVGI 100
KGPLTTPVGG GIRSLNVALR QELDLYVCLR PVRYYEGTPS PVKQPELTDM 150
VIFRENAEDI YAGIEWKADS AEAKKVIDFL QNEMGVKKIR FPENCGIGIK 200
PMSEAGTKRL VRAALEYVID NDRDSLTLVH KGNIMKFTEG AFKDWGYQLA 250
REEFGAELID GGPWCQFKNP KTGKNIIVKD VIADAFLQQI LLRPAEYDVI 300
ATMNLNGDYI SDALAAQVGG IGIAPGANIG DGIALFEATH GTAPKYAGQD 350
KVNPGSLILS AEMMLRYMGW FEAADLIVKG MEGAIRNKTV TYDFERLMEG 400
ATLRKCSEFA DDMISQM 417
Length:417
Mass (Da):45,794
Last modified:July 7, 2009 - v1
Checksum:i821DAB96A98CCED9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001616 Genomic DNA. Translation: ACQ93920.1.
RefSeqiYP_002893506.1. NC_012691.1.

Genome annotation databases

EnsemblBacteriaiACQ93920; ACQ93920; Tola_2323.
GeneIDi7886258.
KEGGitau:Tola_2323.
PATRICi23981299. VBITolAue42623_2304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001616 Genomic DNA. Translation: ACQ93920.1 .
RefSeqi YP_002893506.1. NC_012691.1.

3D structure databases

ProteinModelPortali C4L950.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 595494.Tola_2323.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ93920 ; ACQ93920 ; Tola_2323 .
GeneIDi 7886258.
KEGGi tau:Tola_2323.
PATRICi 23981299. VBITolAue42623_2304.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci TAUE595494:GHEF-2398-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9187 / TA4.

Entry informationi

Entry nameiC4L950_TOLAT
AccessioniPrimary (citable) accession number: C4L950
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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