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Protein

Isocitrate dehydrogenase [NADP]

Gene

Tola_2323

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-2398-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Tola_2323Imported
OrganismiTolumonas auensis (strain DSM 9187 / TA4)Imported
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
ProteomesiUP000009073 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi595494.Tola_2323.

Structurei

3D structure databases

ProteinModelPortaliC4L950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4L950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKIVVPAT GEKISVDAAG KLVVPNNPII PFIEGDGIGV DVTPAMLKVV
60 70 80 90 100
DAAVEKAYKG EKKISWMEIY TGEKSTKIYG DDVWLPAETM DAMREYHVGI
110 120 130 140 150
KGPLTTPVGG GIRSLNVALR QELDLYVCLR PVRYYEGTPS PVKQPELTDM
160 170 180 190 200
VIFRENAEDI YAGIEWKADS AEAKKVIDFL QNEMGVKKIR FPENCGIGIK
210 220 230 240 250
PMSEAGTKRL VRAALEYVID NDRDSLTLVH KGNIMKFTEG AFKDWGYQLA
260 270 280 290 300
REEFGAELID GGPWCQFKNP KTGKNIIVKD VIADAFLQQI LLRPAEYDVI
310 320 330 340 350
ATMNLNGDYI SDALAAQVGG IGIAPGANIG DGIALFEATH GTAPKYAGQD
360 370 380 390 400
KVNPGSLILS AEMMLRYMGW FEAADLIVKG MEGAIRNKTV TYDFERLMEG
410
ATLRKCSEFA DDMISQM
Length:417
Mass (Da):45,794
Last modified:July 7, 2009 - v1
Checksum:i821DAB96A98CCED9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA. Translation: ACQ93920.1.
RefSeqiWP_015879388.1. NC_012691.1.
YP_002893506.1. NC_012691.1.

Genome annotation databases

EnsemblBacteriaiACQ93920; ACQ93920; Tola_2323.
KEGGitau:Tola_2323.
PATRICi23981299. VBITolAue42623_2304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA. Translation: ACQ93920.1.
RefSeqiWP_015879388.1. NC_012691.1.
YP_002893506.1. NC_012691.1.

3D structure databases

ProteinModelPortaliC4L950.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi595494.Tola_2323.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ93920; ACQ93920; Tola_2323.
KEGGitau:Tola_2323.
PATRICi23981299. VBITolAue42623_2304.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-2398-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9187 / TA4Imported.

Entry informationi

Entry nameiC4L950_TOLAT
AccessioniPrimary (citable) accession number: C4L950
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: April 29, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.