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C4L950

- C4L950_TOLAT

UniProt

C4L950 - C4L950_TOLAT

Protein

Isocitrate dehydrogenase [NADP]

Gene

Tola_2323

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciTAUE595494:GHEF-2398-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Tola_2323Imported
    OrganismiTolumonas auensis (strain DSM 9187 / TA4)Imported
    Taxonomic identifieri595494 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
    ProteomesiUP000009073: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi595494.Tola_2323.

    Structurei

    3D structure databases

    ProteinModelPortaliC4L950.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4L950-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESKIVVPAT GEKISVDAAG KLVVPNNPII PFIEGDGIGV DVTPAMLKVV    50
    DAAVEKAYKG EKKISWMEIY TGEKSTKIYG DDVWLPAETM DAMREYHVGI 100
    KGPLTTPVGG GIRSLNVALR QELDLYVCLR PVRYYEGTPS PVKQPELTDM 150
    VIFRENAEDI YAGIEWKADS AEAKKVIDFL QNEMGVKKIR FPENCGIGIK 200
    PMSEAGTKRL VRAALEYVID NDRDSLTLVH KGNIMKFTEG AFKDWGYQLA 250
    REEFGAELID GGPWCQFKNP KTGKNIIVKD VIADAFLQQI LLRPAEYDVI 300
    ATMNLNGDYI SDALAAQVGG IGIAPGANIG DGIALFEATH GTAPKYAGQD 350
    KVNPGSLILS AEMMLRYMGW FEAADLIVKG MEGAIRNKTV TYDFERLMEG 400
    ATLRKCSEFA DDMISQM 417
    Length:417
    Mass (Da):45,794
    Last modified:July 7, 2009 - v1
    Checksum:i821DAB96A98CCED9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001616 Genomic DNA. Translation: ACQ93920.1.
    RefSeqiYP_002893506.1. NC_012691.1.

    Genome annotation databases

    EnsemblBacteriaiACQ93920; ACQ93920; Tola_2323.
    GeneIDi7886258.
    KEGGitau:Tola_2323.
    PATRICi23981299. VBITolAue42623_2304.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001616 Genomic DNA. Translation: ACQ93920.1 .
    RefSeqi YP_002893506.1. NC_012691.1.

    3D structure databases

    ProteinModelPortali C4L950.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 595494.Tola_2323.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ93920 ; ACQ93920 ; Tola_2323 .
    GeneIDi 7886258.
    KEGGi tau:Tola_2323.
    PATRICi 23981299. VBITolAue42623_2304.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci TAUE595494:GHEF-2398-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 9187 / TA4Imported.

    Entry informationi

    Entry nameiC4L950_TOLAT
    AccessioniPrimary (citable) accession number: C4L950
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3