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C4L8Y7

- NADK_TOLAT

UniProt

C4L8Y7 - NADK_TOLAT

Protein

NAD kinase

Gene

nadK

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Proton acceptorUniRule annotation
    Binding sitei158 – 1581NADUniRule annotation
    Binding sitei175 – 1751NADUniRule annotation
    Binding sitei177 – 1771NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi73 – 742NADUniRule annotation
    Nucleotide bindingi147 – 1482NADUniRule annotation
    Nucleotide bindingi188 – 1936NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTAUE595494:GHEF-2328-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Tola_2259
    OrganismiTolumonas auensis (strain DSM 9187 / TA4)
    Taxonomic identifieri595494 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
    ProteomesiUP000009073: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294NAD kinasePRO_1000205434Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi595494.Tola_2259.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OMAiTHEMLYH.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4L8Y7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQAFRTLAL LGKANNDDVN QTINALYKFL REQNYNVLTE TRLAHQLPCP    50
    AEHCMDIVEL GKNADLAIVV GGDGHMLGAA RVLARYDVPV IGVNRGNLGF 100
    LTDLSPHDFE VSLQQVLSGD YQTEHRFLLE TTIYRHGEPK SSNTALNEAV 150
    LHPGKIAHMI EYSVYIDDSF VFSQRADGMI VSTPTGSTAY ALSAGGPILM 200
    PQLDVMTLVP MFPHTLSCRP IVIDAHRQVK LVISPDNPDE QLHVSCDGHV 250
    TLSVHPGDEI IIRRAPHQLT LLHPKDYDYF NVLRTKLGWS NQLF 294
    Length:294
    Mass (Da):32,659
    Last modified:July 7, 2009 - v1
    Checksum:i9894E8C974C3C228
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001616 Genomic DNA. Translation: ACQ93857.1.
    RefSeqiYP_002893443.1. NC_012691.1.

    Genome annotation databases

    EnsemblBacteriaiACQ93857; ACQ93857; Tola_2259.
    GeneIDi7886025.
    KEGGitau:Tola_2259.
    PATRICi23981167. VBITolAue42623_2243.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001616 Genomic DNA. Translation: ACQ93857.1 .
    RefSeqi YP_002893443.1. NC_012691.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 595494.Tola_2259.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ93857 ; ACQ93857 ; Tola_2259 .
    GeneIDi 7886025.
    KEGGi tau:Tola_2259.
    PATRICi 23981167. VBITolAue42623_2243.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OMAi THEMLYH.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci TAUE595494:GHEF-2328-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 9187 / TA4.

    Entry informationi

    Entry nameiNADK_TOLAT
    AccessioniPrimary (citable) accession number: C4L8Y7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3