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C4L8H9

- THIM_TOLAT

UniProt

C4L8H9 - THIM_TOLAT

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491Substrate; via amide nitrogenUniRule annotation
    Binding sitei124 – 1241ATPUniRule annotation
    Binding sitei170 – 1701ATPUniRule annotation
    Binding sitei197 – 1971Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTAUE595494:GHEF-236-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:Tola_0219
    OrganismiTolumonas auensis (strain DSM 9187 / TA4)
    Taxonomic identifieri595494 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
    ProteomesiUP000009073: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Hydroxyethylthiazole kinasePRO_0000383909Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi595494.Tola_0219.

    Structurei

    3D structure databases

    ProteinModelPortaliC4L8H9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiQTFTANV.
    OrthoDBiEOG6QZMM6.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4L8H9-1 [UniParc]FASTAAdd to Basket

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    MPQALPATIV ATHLERIRRS VPLTHVITND VVTGFTANVL LALGAAPAMI    50
    TAPEEAGSFA AIASVLSVNV GTLTSAQAAT IRIAVQSANQ AGTPWVLDPV 100
    AAGVLPYRTE LCRELLQQHP AAIRGNASEI MALAGQAAAG KGVDSANQSD 150
    QAIEAAQVLA KSSGAIVAVT GEIDYITDGE RVVSIKAGDP LMTRVTGTGC 200
    ALSSVVAAFI AGCEEKDRLD AVASACAVMA IAGQRAAAKA KGPGSFVPAF 250
    LDNLYLLDAV TIAEALA 267
    Length:267
    Mass (Da):27,024
    Last modified:July 7, 2009 - v1
    Checksum:i82569F965C91792E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001616 Genomic DNA. Translation: ACQ91849.1.
    RefSeqiYP_002891435.1. NC_012691.1.

    Genome annotation databases

    EnsemblBacteriaiACQ91849; ACQ91849; Tola_0219.
    GeneIDi7885732.
    KEGGitau:Tola_0219.
    PATRICi23977031. VBITolAue42623_0223.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001616 Genomic DNA. Translation: ACQ91849.1 .
    RefSeqi YP_002891435.1. NC_012691.1.

    3D structure databases

    ProteinModelPortali C4L8H9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 595494.Tola_0219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ91849 ; ACQ91849 ; Tola_0219 .
    GeneIDi 7885732.
    KEGGi tau:Tola_0219.
    PATRICi 23977031. VBITolAue42623_0223.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi QTFTANV.
    OrthoDBi EOG6QZMM6.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci TAUE595494:GHEF-236-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 9187 / TA4.

    Entry informationi

    Entry nameiTHIM_TOLAT
    AccessioniPrimary (citable) accession number: C4L8H9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3