SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C4L8H9

- THIM_TOLAT

UniProt

C4L8H9 - THIM_TOLAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Hydroxyethylthiazole kinase

Gene
thiM, Tola_0219
Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491Substrate; via amide nitrogen By similarity
Binding sitei124 – 1241ATP By similarity
Binding sitei170 – 1701ATP By similarity
Binding sitei197 – 1971Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-236-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:Tola_0219
OrganismiTolumonas auensis (strain DSM 9187 / TA4)
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
ProteomesiUP000009073: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Hydroxyethylthiazole kinaseUniRule annotationPRO_0000383909Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi595494.Tola_0219.

Structurei

3D structure databases

ProteinModelPortaliC4L8H9.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG6QZMM6.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

C4L8H9-1 [UniParc]FASTAAdd to Basket

« Hide

MPQALPATIV ATHLERIRRS VPLTHVITND VVTGFTANVL LALGAAPAMI    50
TAPEEAGSFA AIASVLSVNV GTLTSAQAAT IRIAVQSANQ AGTPWVLDPV 100
AAGVLPYRTE LCRELLQQHP AAIRGNASEI MALAGQAAAG KGVDSANQSD 150
QAIEAAQVLA KSSGAIVAVT GEIDYITDGE RVVSIKAGDP LMTRVTGTGC 200
ALSSVVAAFI AGCEEKDRLD AVASACAVMA IAGQRAAAKA KGPGSFVPAF 250
LDNLYLLDAV TIAEALA 267
Length:267
Mass (Da):27,024
Last modified:July 7, 2009 - v1
Checksum:i82569F965C91792E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001616 Genomic DNA. Translation: ACQ91849.1.
RefSeqiYP_002891435.1. NC_012691.1.

Genome annotation databases

EnsemblBacteriaiACQ91849; ACQ91849; Tola_0219.
GeneIDi7885732.
KEGGitau:Tola_0219.
PATRICi23977031. VBITolAue42623_0223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001616 Genomic DNA. Translation: ACQ91849.1 .
RefSeqi YP_002891435.1. NC_012691.1.

3D structure databases

ProteinModelPortali C4L8H9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 595494.Tola_0219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ91849 ; ACQ91849 ; Tola_0219 .
GeneIDi 7885732.
KEGGi tau:Tola_0219.
PATRICi 23977031. VBITolAue42623_0223.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG6QZMM6.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci TAUE595494:GHEF-236-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9187 / TA4.

Entry informationi

Entry nameiTHIM_TOLAT
AccessioniPrimary (citable) accession number: C4L8H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: June 11, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi