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C4L8H9

- THIM_TOLAT

UniProt

C4L8H9 - THIM_TOLAT

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491Substrate; via amide nitrogenUniRule annotation
Binding sitei124 – 1241ATPUniRule annotation
Binding sitei170 – 1701ATPUniRule annotation
Binding sitei197 – 1971Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-236-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:Tola_0219
OrganismiTolumonas auensis (strain DSM 9187 / TA4)
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
ProteomesiUP000009073: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Hydroxyethylthiazole kinasePRO_0000383909Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi595494.Tola_0219.

Structurei

3D structure databases

ProteinModelPortaliC4L8H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG6QZMM6.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

C4L8H9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPQALPATIV ATHLERIRRS VPLTHVITND VVTGFTANVL LALGAAPAMI
60 70 80 90 100
TAPEEAGSFA AIASVLSVNV GTLTSAQAAT IRIAVQSANQ AGTPWVLDPV
110 120 130 140 150
AAGVLPYRTE LCRELLQQHP AAIRGNASEI MALAGQAAAG KGVDSANQSD
160 170 180 190 200
QAIEAAQVLA KSSGAIVAVT GEIDYITDGE RVVSIKAGDP LMTRVTGTGC
210 220 230 240 250
ALSSVVAAFI AGCEEKDRLD AVASACAVMA IAGQRAAAKA KGPGSFVPAF
260
LDNLYLLDAV TIAEALA
Length:267
Mass (Da):27,024
Last modified:July 7, 2009 - v1
Checksum:i82569F965C91792E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA. Translation: ACQ91849.1.
RefSeqiWP_012728448.1. NC_012691.1.
YP_002891435.1. NC_012691.1.

Genome annotation databases

EnsemblBacteriaiACQ91849; ACQ91849; Tola_0219.
GeneIDi7885732.
KEGGitau:Tola_0219.
PATRICi23977031. VBITolAue42623_0223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA. Translation: ACQ91849.1 .
RefSeqi WP_012728448.1. NC_012691.1.
YP_002891435.1. NC_012691.1.

3D structure databases

ProteinModelPortali C4L8H9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 595494.Tola_0219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ91849 ; ACQ91849 ; Tola_0219 .
GeneIDi 7885732.
KEGGi tau:Tola_0219.
PATRICi 23977031. VBITolAue42623_0223.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG6QZMM6.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci TAUE595494:GHEF-236-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9187 / TA4.

Entry informationi

Entry nameiTHIM_TOLAT
AccessioniPrimary (citable) accession number: C4L8H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: November 26, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3