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C4L6J6

- PNP_EXISA

UniProt

C4L6J6 - PNP_EXISA

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi487 – 4871MagnesiumUniRule annotation
Metal bindingi493 – 4931MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciESP360911:GI4R-3059-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:EAT1b_2961
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000000716: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Polyribonucleotide nucleotidyltransferasePRO_1000215659Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360911.EAT1b_2961.

Structurei

3D structure databases

ProteinModelPortaliC4L6J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini554 – 61360KHUniRule annotationAdd
BLAST
Domaini623 – 69169S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRRIITHD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4L6J6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGTKQVFST EWGGRPLSVE VGQLAKQANG SALVRYGDTV VLATVTASKA
60 70 80 90 100
PKDLDFFPLT VNYEEKLYSV GKIPGGFLRR EGRPGENAIL TSRLIDRPIR
110 120 130 140 150
PLFPDGFRHD IQVMIYVMSN DPDCSAEMAG MLGTSIALSI SDVPFDGPIA
160 170 180 190 200
GVTVGRVDGE FVINPTTAQL EKTDLELQVA GTSTAINMVE AGANEVPEDV
210 220 230 240 250
MLESILFGHE EIKRLIAFQQ EIVEAVGKPK FEYTVSKYDE ALTAELEAAR
260 270 280 290 300
PEIVEAVQVE EKHARDEAIN EVIAKYVAMY EARLADEPSK LGEVSGILNK
310 320 330 340 350
FVKDEVRRLI TVEKVRPDGR RPDVIRPLAS EVGLLPRAHG VGLFTRGQTQ
360 370 380 390 400
VMSVATLGVI GDAQIIDGIG LEENKRFMHH YNFPPFSVGE ARPVRAPGRR
410 420 430 440 450
EIGHGALGER ALLPIIPKEA DFPYTIRLVS EVLESNGSSS QASICGSTLA
460 470 480 490 500
LMDAGVPIKA PVAGIAMGLI MEGEHYTVLT DIQGLEDHLG DMDFKVAGTK
510 520 530 540 550
DGITALQMDI KIAGITREIL EEALEQARVG RLHILDHMLE TLETPRTQLS
560 570 580 590 600
KYAPKIVTMT INPDKIRDVI GPGGKMINSI IDQTGVKIDI EQDGTVFIAS
610 620 630 640 650
TDQEGIDLAM SMIGDIVREV VVGEVYDATV RRIEKFGAFV ELFKGKDALV
660 670 680 690 700
HVSEFSLERV ANVEDVVKLG DSIQVKVTEI DDKGRVNASR KALILEGLSP
710 720 730
EEREAYEAKR KAARESRPPR DSRPPRRDGD RRPPRSTN
Length:738
Mass (Da):80,709
Last modified:July 7, 2009 - v1
Checksum:i22F793DF92F2024B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001615 Genomic DNA. Translation: ACQ71875.1.
RefSeqiWP_015881434.1. NC_012673.1.
YP_002887320.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ71875; ACQ71875; EAT1b_2961.
GeneIDi7871104.
KEGGieat:EAT1b_2961.
PATRICi21881182. VBIExiSp39724_2937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001615 Genomic DNA. Translation: ACQ71875.1 .
RefSeqi WP_015881434.1. NC_012673.1.
YP_002887320.1. NC_012673.1.

3D structure databases

ProteinModelPortali C4L6J6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360911.EAT1b_2961.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ71875 ; ACQ71875 ; EAT1b_2961 .
GeneIDi 7871104.
KEGGi eat:EAT1b_2961.
PATRICi 21881182. VBIExiSp39724_2937.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi RRIITHD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ESP360911:GI4R-3059-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1b.

Entry informationi

Entry nameiPNP_EXISA
AccessioniPrimary (citable) accession number: C4L6J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3