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C4L5W7 (C4L5W7_EXISA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:EAT1b_2859
OrganismExiguobacterium sp. (strain ATCC BAA-1283 / AT1b) [Complete proteome] [HAMAP] EMBL ACQ71773.1
Taxonomic identifier360911 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region117 – 12595-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9515-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9715-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1211Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
C4L5W7 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: FA0BDD80E3FC4E51

FASTA20822,278
        10         20         30         40         50         60 
MKQIAEALLQ IEAVTLSPTE PYTWSSGLKS PIYCDNRLTL SFPNVRQVIV DGLVKSVNPT 

        70         80         90        100        110        120 
EVDVIAGTAT AGIPHGALLA DRLGLPFIYV RSSAKGHGKG NQIEGKLEAG ARVLVIEDLL 

       130        140        150        160        170        180 
STGMSSIDAA QAIREAGGEV TRIQAIFSYG LPVLEKNLAD ANLSATSLTT FSELIEVAEN 

       190        200 
TGVLNRSELD SLRDWQEDPR AWSDLVTS

« Hide

References

[1]"Complete sequence of Exiguobacterium sp. AT1b."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G. expand/collapse author list , Ramaley R.F., Rodrigues D.F., Vishnivetskaya T.A., Kathariou S., Tiedje J.M., Richardson P.
Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1283 / AT1b.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001615 Genomic DNA. Translation: ACQ71773.1.
RefSeqYP_002887218.1. NC_012673.1.

3D structure databases

ProteinModelPortalC4L5W7.
ModBaseSearch...

Protein-protein interaction databases

STRINGC4L5W7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7870114.
GenomeReviewsGene locus EAT1b_2859 in contig CP001615_GR.
KEGGeat:EAT1b_2859.
PATRIC21880978. VBIExiSp39724_2835.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMALPMTYVR.
ProtClustDBCLSK2489552.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC4L5W7_EXISA
AccessionPrimary (citable) accession number: C4L5W7
Entry history
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info