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C4L521

- C4L521_EXISA

UniProt

C4L521 - C4L521_EXISA

Protein

Quinolinate synthase A

Gene

nadA

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotation

    Catalytic activityi

    Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391IminoaspartateUniRule annotation
    Binding sitei56 – 561Iminoaspartate; via amide nitrogenUniRule annotation
    Binding sitei134 – 1341IminoaspartateUniRule annotation
    Binding sitei155 – 1551IminoaspartateUniRule annotation
    Binding sitei249 – 2491IminoaspartateUniRule annotation
    Binding sitei266 – 2661IminoaspartateUniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. quinolinate synthetase A activity Source: UniProtKB-HAMAP
    4. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciESP360911:GI4R-2787-MONOMER.
    UniPathwayiUPA00253; UER00327.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
    Gene namesi
    Name:nadAUniRule annotation
    Ordered Locus Names:EAT1b_2690Imported
    OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)Imported
    Taxonomic identifieri360911 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
    ProteomesiUP000000716: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi360911.EAT1b_2690.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the quinolinate synthase A family. Type 3 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0379.
    HOGENOMiHOG000222768.
    KOiK03517.
    OMAiKDEVIQF.
    OrthoDBiEOG6DJZ56.

    Family and domain databases

    HAMAPiMF_00569. NadA_type3.
    InterProiIPR003473. NadA.
    IPR023515. Quinolinate_synth_A_type3.
    [Graphical view]
    PfamiPF02445. NadA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00550. nadA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4L521-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLLGTLPPT YANLSVEEME TRIQAVKDRL GTRLFLPAHH YQKDEVVQFA    50
    DATGDSLQLA RLAEQMSEAE FIVFCGVHFM AETADMLTRD DQIVVLPDMR 100
    AGCSMADMAD IDQTEIAWEE LTERFGEDII PITYVNSTAA IKAFVGRHGG 150
    ATVTSSNAHE IVRWALEAGE RILFLPDQHL GRNTAYDLGI PLEAMAVWDP 200
    LREELVAEGD DEQVKVILWK GHCSVHEKFT VSQIQAFRER EPDRRIIVHP 250
    ECTFDVVQAA DEAGSTSYII DKIDASAPGT KWAVGTEMNL VNRLAATYPH 300
    LDIVSLNPFM CPCLTMNRID LPHLLWALES LETDPVNIIR VDHETTEFSK 350
    RALERMLAR 359
    Length:359
    Mass (Da):40,318
    Last modified:July 7, 2009 - v1
    Checksum:i6994029E4D6D3B2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001615 Genomic DNA. Translation: ACQ71606.1.
    RefSeqiWP_015881165.1. NC_012673.1.
    YP_002887051.1. NC_012673.1.

    Genome annotation databases

    EnsemblBacteriaiACQ71606; ACQ71606; EAT1b_2690.
    GeneIDi7868894.
    KEGGieat:EAT1b_2690.
    PATRICi21880638. VBIExiSp39724_2665.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001615 Genomic DNA. Translation: ACQ71606.1 .
    RefSeqi WP_015881165.1. NC_012673.1.
    YP_002887051.1. NC_012673.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360911.EAT1b_2690.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ71606 ; ACQ71606 ; EAT1b_2690 .
    GeneIDi 7868894.
    KEGGi eat:EAT1b_2690.
    PATRICi 21880638. VBIExiSp39724_2665.

    Phylogenomic databases

    eggNOGi COG0379.
    HOGENOMi HOG000222768.
    KOi K03517.
    OMAi KDEVIQF.
    OrthoDBi EOG6DJZ56.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00327 .
    BioCyci ESP360911:GI4R-2787-MONOMER.

    Family and domain databases

    HAMAPi MF_00569. NadA_type3.
    InterProi IPR003473. NadA.
    IPR023515. Quinolinate_synth_A_type3.
    [Graphical view ]
    Pfami PF02445. NadA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00550. nadA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1283 / AT1bImported.

    Entry informationi

    Entry nameiC4L521_EXISA
    AccessioniPrimary (citable) accession number: C4L521
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3