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Protein

Quinolinate synthase A

Gene

nadA

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotationSAAS annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase A (nadA)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39IminoaspartateUniRule annotation1
Binding sitei56Iminoaspartate; via amide nitrogenUniRule annotation1
Binding sitei134IminoaspartateUniRule annotation1
Binding sitei155IminoaspartateUniRule annotation1
Binding sitei249IminoaspartateUniRule annotation1
Binding sitei266IminoaspartateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processPyridine nucleotide biosynthesisUniRule annotationSAAS annotation
Ligand4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciESP360911:G1GVI-2757-MONOMER
UniPathwayiUPA00253; UER00327

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:EAT1b_2690Imported
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)Imported
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
Proteomesi
  • UP000000716 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi360911.EAT1b_2690

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 3 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0I Bacteria
COG0379 LUCA
HOGENOMiHOG000222768
KOiK03517
OMAiDKCLGEN
OrthoDBiPOG091H03D2

Family and domain databases

HAMAPiMF_00569 NadA_type3, 1 hit
InterProiView protein in InterPro
IPR003473 NadA
IPR036094 NadA_sf
IPR023515 Quinolinate_synth_A_type3
PANTHERiPTHR30573 PTHR30573, 1 hit
PfamiView protein in Pfam
PF02445 NadA, 1 hit
SUPFAMiSSF142754 SSF142754, 1 hit
TIGRFAMsiTIGR00550 nadA, 1 hit

Sequencei

Sequence statusi: Complete.

C4L521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLGTLPPT YANLSVEEME TRIQAVKDRL GTRLFLPAHH YQKDEVVQFA
60 70 80 90 100
DATGDSLQLA RLAEQMSEAE FIVFCGVHFM AETADMLTRD DQIVVLPDMR
110 120 130 140 150
AGCSMADMAD IDQTEIAWEE LTERFGEDII PITYVNSTAA IKAFVGRHGG
160 170 180 190 200
ATVTSSNAHE IVRWALEAGE RILFLPDQHL GRNTAYDLGI PLEAMAVWDP
210 220 230 240 250
LREELVAEGD DEQVKVILWK GHCSVHEKFT VSQIQAFRER EPDRRIIVHP
260 270 280 290 300
ECTFDVVQAA DEAGSTSYII DKIDASAPGT KWAVGTEMNL VNRLAATYPH
310 320 330 340 350
LDIVSLNPFM CPCLTMNRID LPHLLWALES LETDPVNIIR VDHETTEFSK

RALERMLAR
Length:359
Mass (Da):40,318
Last modified:July 7, 2009 - v1
Checksum:i6994029E4D6D3B2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA Translation: ACQ71606.1
RefSeqiWP_015881165.1, NC_012673.1

Genome annotation databases

EnsemblBacteriaiACQ71606; ACQ71606; EAT1b_2690
KEGGieat:EAT1b_2690

Similar proteinsi

Entry informationi

Entry nameiC4L521_EXISA
AccessioniPrimary (citable) accession number: C4L521
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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