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C4L521

- C4L521_EXISA

UniProt

C4L521 - C4L521_EXISA

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Protein

Quinolinate synthase A

Gene
nadA, EAT1b_2690
Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotations

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Iminoaspartate By similarityUniRule annotation
Binding sitei56 – 561Iminoaspartate; via amide nitrogen By similarityUniRule annotation
Binding sitei134 – 1341Iminoaspartate By similarityUniRule annotation
Binding sitei155 – 1551Iminoaspartate By similarityUniRule annotation
Binding sitei249 – 2491Iminoaspartate By similarityUniRule annotation
Binding sitei266 – 2661Iminoaspartate By similarityUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. quinolinate synthetase A activity Source: UniProtKB-HAMAP
  4. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotations

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotations, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciESP360911:GI4R-2787-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:EAT1b_2690Imported
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)Imported
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000000716: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi360911.EAT1b_2690.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0379.
HOGENOMiHOG000222768.
KOiK03517.
OMAiKDEVIQF.
OrthoDBiEOG6DJZ56.

Family and domain databases

HAMAPiMF_00569. NadA_type3.
InterProiIPR003473. NadA.
IPR023515. Quinolinate_synth_A_type3.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

C4L521-1 [UniParc]FASTAAdd to Basket

« Hide

MQLLGTLPPT YANLSVEEME TRIQAVKDRL GTRLFLPAHH YQKDEVVQFA    50
DATGDSLQLA RLAEQMSEAE FIVFCGVHFM AETADMLTRD DQIVVLPDMR 100
AGCSMADMAD IDQTEIAWEE LTERFGEDII PITYVNSTAA IKAFVGRHGG 150
ATVTSSNAHE IVRWALEAGE RILFLPDQHL GRNTAYDLGI PLEAMAVWDP 200
LREELVAEGD DEQVKVILWK GHCSVHEKFT VSQIQAFRER EPDRRIIVHP 250
ECTFDVVQAA DEAGSTSYII DKIDASAPGT KWAVGTEMNL VNRLAATYPH 300
LDIVSLNPFM CPCLTMNRID LPHLLWALES LETDPVNIIR VDHETTEFSK 350
RALERMLAR 359
Length:359
Mass (Da):40,318
Last modified:July 7, 2009 - v1
Checksum:i6994029E4D6D3B2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001615 Genomic DNA. Translation: ACQ71606.1.
RefSeqiWP_015881165.1. NC_012673.1.
YP_002887051.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ71606; ACQ71606; EAT1b_2690.
GeneIDi7868894.
KEGGieat:EAT1b_2690.
PATRICi21880638. VBIExiSp39724_2665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001615 Genomic DNA. Translation: ACQ71606.1 .
RefSeqi WP_015881165.1. NC_012673.1.
YP_002887051.1. NC_012673.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360911.EAT1b_2690.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ71606 ; ACQ71606 ; EAT1b_2690 .
GeneIDi 7868894.
KEGGi eat:EAT1b_2690.
PATRICi 21880638. VBIExiSp39724_2665.

Phylogenomic databases

eggNOGi COG0379.
HOGENOMi HOG000222768.
KOi K03517.
OMAi KDEVIQF.
OrthoDBi EOG6DJZ56.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00327 .
BioCyci ESP360911:GI4R-2787-MONOMER.

Family and domain databases

HAMAPi MF_00569. NadA_type3.
InterProi IPR003473. NadA.
IPR023515. Quinolinate_synth_A_type3.
[Graphical view ]
Pfami PF02445. NadA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00550. nadA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1b.

Entry informationi

Entry nameiC4L521_EXISA
AccessioniPrimary (citable) accession number: C4L521
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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