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Protein

Quinolinate synthase A

Gene

nadA

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • [4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation
  • [4Fe-4S] clusterSAAS annotationNote: Binds 1 [4Fe-4S] cluster per subunit.SAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391IminoaspartateUniRule annotation
Binding sitei56 – 561Iminoaspartate; via amide nitrogenUniRule annotation
Binding sitei134 – 1341IminoaspartateUniRule annotation
Binding sitei155 – 1551IminoaspartateUniRule annotation
Binding sitei249 – 2491IminoaspartateUniRule annotation
Binding sitei266 – 2661IminoaspartateUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. quinolinate synthetase A activity Source: UniProtKB-HAMAP
  4. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciESP360911:GI4R-2787-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:EAT1b_2690Imported
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)Imported
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000000716 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi360911.EAT1b_2690.

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 3 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0379.
HOGENOMiHOG000222768.
KOiK03517.
OMAiKDEVIQF.
OrthoDBiEOG6DJZ56.

Family and domain databases

HAMAPiMF_00569. NadA_type3.
InterProiIPR003473. NadA.
IPR023515. Quinolinate_synth_A_type3.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

C4L521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLGTLPPT YANLSVEEME TRIQAVKDRL GTRLFLPAHH YQKDEVVQFA
60 70 80 90 100
DATGDSLQLA RLAEQMSEAE FIVFCGVHFM AETADMLTRD DQIVVLPDMR
110 120 130 140 150
AGCSMADMAD IDQTEIAWEE LTERFGEDII PITYVNSTAA IKAFVGRHGG
160 170 180 190 200
ATVTSSNAHE IVRWALEAGE RILFLPDQHL GRNTAYDLGI PLEAMAVWDP
210 220 230 240 250
LREELVAEGD DEQVKVILWK GHCSVHEKFT VSQIQAFRER EPDRRIIVHP
260 270 280 290 300
ECTFDVVQAA DEAGSTSYII DKIDASAPGT KWAVGTEMNL VNRLAATYPH
310 320 330 340 350
LDIVSLNPFM CPCLTMNRID LPHLLWALES LETDPVNIIR VDHETTEFSK

RALERMLAR
Length:359
Mass (Da):40,318
Last modified:July 7, 2009 - v1
Checksum:i6994029E4D6D3B2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ71606.1.
RefSeqiYP_002887051.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ71606; ACQ71606; EAT1b_2690.
KEGGieat:EAT1b_2690.
PATRICi21880638. VBIExiSp39724_2665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ71606.1.
RefSeqiYP_002887051.1. NC_012673.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360911.EAT1b_2690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ71606; ACQ71606; EAT1b_2690.
KEGGieat:EAT1b_2690.
PATRICi21880638. VBIExiSp39724_2665.

Phylogenomic databases

eggNOGiCOG0379.
HOGENOMiHOG000222768.
KOiK03517.
OMAiKDEVIQF.
OrthoDBiEOG6DJZ56.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00327.
BioCyciESP360911:GI4R-2787-MONOMER.

Family and domain databases

HAMAPiMF_00569. NadA_type3.
InterProiIPR003473. NadA.
IPR023515. Quinolinate_synth_A_type3.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1bImported.

Entry informationi

Entry nameiC4L521_EXISA
AccessioniPrimary (citable) accession number: C4L521
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: April 1, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.