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C4L521 (C4L521_EXISA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Quinolinate synthase A HAMAP-Rule MF_00569
EC=2.5.1.72 HAMAP-Rule MF_00569
Gene names
Name:nadA HAMAP-Rule MF_00569
Ordered Locus Names:EAT1b_2690
OrganismExiguobacterium sp. (strain ATCC BAA-1283 / AT1b) [Complete proteome] [HAMAP] EMBL ACQ71606.1
Taxonomic identifier360911 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate By similarity. HAMAP-Rule MF_00569

Catalytic activity

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate. HAMAP-Rule MF_00569

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP-Rule MF_00569

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. HAMAP-Rule MF_00569

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00569.

Sequence similarities

Belongs to the quinolinate synthase A family. Type 3 subfamily. HAMAP-Rule MF_00569

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site391Iminoaspartate By similarity HAMAP-Rule MF_00569
Binding site561Iminoaspartate; via amide nitrogen By similarity HAMAP-Rule MF_00569
Binding site1341Iminoaspartate By similarity HAMAP-Rule MF_00569
Binding site1551Iminoaspartate By similarity HAMAP-Rule MF_00569
Binding site2491Iminoaspartate By similarity HAMAP-Rule MF_00569
Binding site2661Iminoaspartate By similarity HAMAP-Rule MF_00569

Sequences

Sequence LengthMass (Da)Tools
C4L521 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: 6994029E4D6D3B2C

FASTA35940,318
        10         20         30         40         50         60 
MQLLGTLPPT YANLSVEEME TRIQAVKDRL GTRLFLPAHH YQKDEVVQFA DATGDSLQLA 

        70         80         90        100        110        120 
RLAEQMSEAE FIVFCGVHFM AETADMLTRD DQIVVLPDMR AGCSMADMAD IDQTEIAWEE 

       130        140        150        160        170        180 
LTERFGEDII PITYVNSTAA IKAFVGRHGG ATVTSSNAHE IVRWALEAGE RILFLPDQHL 

       190        200        210        220        230        240 
GRNTAYDLGI PLEAMAVWDP LREELVAEGD DEQVKVILWK GHCSVHEKFT VSQIQAFRER 

       250        260        270        280        290        300 
EPDRRIIVHP ECTFDVVQAA DEAGSTSYII DKIDASAPGT KWAVGTEMNL VNRLAATYPH 

       310        320        330        340        350 
LDIVSLNPFM CPCLTMNRID LPHLLWALES LETDPVNIIR VDHETTEFSK RALERMLAR

« Hide

References

[1]"Complete sequence of Exiguobacterium sp. AT1b."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G. expand/collapse author list , Ramaley R.F., Rodrigues D.F., Vishnivetskaya T.A., Kathariou S., Tiedje J.M., Richardson P.
Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1283 / AT1b.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001615 Genomic DNA. Translation: ACQ71606.1.
RefSeqYP_002887051.1. NC_012673.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING360911.EAT1b_2690.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ71606; ACQ71606; EAT1b_2690.
GeneID7868894.
KEGGeat:EAT1b_2690.
PATRIC21880638. VBIExiSp39724_2665.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0379.
HOGENOMHOG000222768.
KOK03517.
OMAVGSTEYI.
ProtClustDBPRK09375.

Enzyme and pathway databases

BioCycESP360911:GI4R-2787-MONOMER.
UniPathwayUPA00253; UER00327.

Family and domain databases

HAMAPMF_00569. NadA_type3.
InterProIPR003473. NadA.
IPR023515. Quinolinate_synth_A_type3.
[Graphical view]
PfamPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00550. nadA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC4L521_EXISA
AccessionPrimary (citable) accession number: C4L521
Entry history
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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