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C4L3W2

- ODO1_EXISA

UniProt

C4L3W2 - ODO1_EXISA

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciESP360911:GI4R-2634-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:EAT1b_2538
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000000716: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9519512-oxoglutarate dehydrogenase E1 componentPRO_1000213735Add
BLAST

Proteomic databases

PRIDEiC4L3W2.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi360911.EAT1b_2538.

Structurei

3D structure databases

ProteinModelPortaliC4L3W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQHAPNKE.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

C4L3W2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGESSNVHEK SQAFYGPNLG YIIELYEQYL EDPSSVDEET RRYFDEFGAP
60 70 80 90 100
ETSTPTEVPV SGPSFDLEKV VSATRLINDI RAFGHKAADI YPLKDHPREQ
110 120 130 140 150
ELFELSRYDL TEEDLKQIPA RLLSDDAPKP NASALELFRH LLDVYTGTVA
160 170 180 190 200
IELRHLDDME EKKWIRRQVE QGALQQTFSK EEKIELFKRL AETELFESFL
210 220 230 240 250
HKTYVGQKRF SIEGLDAMVP LLDAMVGGLI SSGSEHINIG MAHRGRLNVL
260 270 280 290 300
AHVLGKPYEM IFAEFQHAPN KELIPSEGSI GINFGWSGDV KYHLGLDRKV
310 320 330 340 350
VEQQKEVRLN LANNPSHLEF VGSVVEGYTR AAQDDRSEKG SAVQHDDLAA
360 370 380 390 400
SILIHGDAAF PGQGIVAETL NMTNLTGYRT GGTVHVIANN TIGFTTDPND
410 420 430 440 450
SRSTRYASDI AKGYEIPVFH VNADDPEACV AVAKLISEYR AKFHKDILVD
460 470 480 490 500
LIGYRRYGHN EMDEPMNTNP VLYKAIKGHQ SVRHVYAARL EEEGVMTKDE
510 520 530 540 550
KAQIEQKIEE ALKAARDLVP SEEEDADIVL PDAVHKGFPK VDTSVEREFL
560 570 580 590 600
TQLNEELLNW PEGFGVFHKL QKVLDRRRDA FSEGGKIDWG HAETLAFASI
610 620 630 640 650
LSDGTPVRLS GQDSERGTFA QRNIMLNDVE SGKKFSPLHE LSTAKASFSV
660 670 680 690 700
YNSPLSEGSV LGFEYGYNVF AQDTLVLWEA QYGDFANSAQ VMFDQFISAG
710 720 730 740 750
RAKWGQKSGL VMLLPHGYEG QGPEHSSARM ERYLTLAGEK NWTVANLSSA
760 770 780 790 800
AQYFHILRRQ AEMLGKEEIR PMIIMTPKSL LRHPLATSPV EAFTEESFKP
810 820 830 840 850
IVEQPGLGEN TEKVERLVFC TGKMAIDLAE AVGKSEESLD FLHIVRVEEI
860 870 880 890 900
YPFPVREIRD VISRYPNARE IVWVQEEPKN MGAWTYIEPR LEAVTTNRLD
910 920 930 940 950
VRYIGRRRRS SPAEGNPTAH KQEQARIIRE ALSRDVVSSG AGTSTYQKDR

K
Length:951
Mass (Da):106,924
Last modified:July 7, 2009 - v1
Checksum:iBB172AC8134ADA9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001615 Genomic DNA. Translation: ACQ71457.1.
RefSeqiWP_015881016.1. NC_012673.1.
YP_002886902.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ71457; ACQ71457; EAT1b_2538.
GeneIDi7870977.
KEGGieat:EAT1b_2538.
PATRICi21880348. VBIExiSp39724_2521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001615 Genomic DNA. Translation: ACQ71457.1 .
RefSeqi WP_015881016.1. NC_012673.1.
YP_002886902.1. NC_012673.1.

3D structure databases

ProteinModelPortali C4L3W2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360911.EAT1b_2538.

Proteomic databases

PRIDEi C4L3W2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ71457 ; ACQ71457 ; EAT1b_2538 .
GeneIDi 7870977.
KEGGi eat:EAT1b_2538.
PATRICi 21880348. VBIExiSp39724_2521.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi QHAPNKE.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci ESP360911:GI4R-2634-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1b.

Entry informationi

Entry nameiODO1_EXISA
AccessioniPrimary (citable) accession number: C4L3W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3