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C4L3W2

- ODO1_EXISA

UniProt

C4L3W2 - ODO1_EXISA

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

    Cofactori

    Thiamine pyrophosphate.UniRule annotation

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciESP360911:GI4R-2634-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenaseUniRule annotation
    Gene namesi
    Name:odhAUniRule annotation
    Ordered Locus Names:EAT1b_2538
    OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
    Taxonomic identifieri360911 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
    ProteomesiUP000000716: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9519512-oxoglutarate dehydrogenase E1 componentPRO_1000213735Add
    BLAST

    Proteomic databases

    PRIDEiC4L3W2.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi360911.EAT1b_2538.

    Structurei

    3D structure databases

    ProteinModelPortaliC4L3W2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259588.
    KOiK00164.
    OMAiQHAPNKE.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01169. SucA_OdhA.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4L3W2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGESSNVHEK SQAFYGPNLG YIIELYEQYL EDPSSVDEET RRYFDEFGAP    50
    ETSTPTEVPV SGPSFDLEKV VSATRLINDI RAFGHKAADI YPLKDHPREQ 100
    ELFELSRYDL TEEDLKQIPA RLLSDDAPKP NASALELFRH LLDVYTGTVA 150
    IELRHLDDME EKKWIRRQVE QGALQQTFSK EEKIELFKRL AETELFESFL 200
    HKTYVGQKRF SIEGLDAMVP LLDAMVGGLI SSGSEHINIG MAHRGRLNVL 250
    AHVLGKPYEM IFAEFQHAPN KELIPSEGSI GINFGWSGDV KYHLGLDRKV 300
    VEQQKEVRLN LANNPSHLEF VGSVVEGYTR AAQDDRSEKG SAVQHDDLAA 350
    SILIHGDAAF PGQGIVAETL NMTNLTGYRT GGTVHVIANN TIGFTTDPND 400
    SRSTRYASDI AKGYEIPVFH VNADDPEACV AVAKLISEYR AKFHKDILVD 450
    LIGYRRYGHN EMDEPMNTNP VLYKAIKGHQ SVRHVYAARL EEEGVMTKDE 500
    KAQIEQKIEE ALKAARDLVP SEEEDADIVL PDAVHKGFPK VDTSVEREFL 550
    TQLNEELLNW PEGFGVFHKL QKVLDRRRDA FSEGGKIDWG HAETLAFASI 600
    LSDGTPVRLS GQDSERGTFA QRNIMLNDVE SGKKFSPLHE LSTAKASFSV 650
    YNSPLSEGSV LGFEYGYNVF AQDTLVLWEA QYGDFANSAQ VMFDQFISAG 700
    RAKWGQKSGL VMLLPHGYEG QGPEHSSARM ERYLTLAGEK NWTVANLSSA 750
    AQYFHILRRQ AEMLGKEEIR PMIIMTPKSL LRHPLATSPV EAFTEESFKP 800
    IVEQPGLGEN TEKVERLVFC TGKMAIDLAE AVGKSEESLD FLHIVRVEEI 850
    YPFPVREIRD VISRYPNARE IVWVQEEPKN MGAWTYIEPR LEAVTTNRLD 900
    VRYIGRRRRS SPAEGNPTAH KQEQARIIRE ALSRDVVSSG AGTSTYQKDR 950
    K 951
    Length:951
    Mass (Da):106,924
    Last modified:July 7, 2009 - v1
    Checksum:iBB172AC8134ADA9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001615 Genomic DNA. Translation: ACQ71457.1.
    RefSeqiWP_015881016.1. NC_012673.1.
    YP_002886902.1. NC_012673.1.

    Genome annotation databases

    EnsemblBacteriaiACQ71457; ACQ71457; EAT1b_2538.
    GeneIDi7870977.
    KEGGieat:EAT1b_2538.
    PATRICi21880348. VBIExiSp39724_2521.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001615 Genomic DNA. Translation: ACQ71457.1 .
    RefSeqi WP_015881016.1. NC_012673.1.
    YP_002886902.1. NC_012673.1.

    3D structure databases

    ProteinModelPortali C4L3W2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360911.EAT1b_2538.

    Proteomic databases

    PRIDEi C4L3W2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ71457 ; ACQ71457 ; EAT1b_2538 .
    GeneIDi 7870977.
    KEGGi eat:EAT1b_2538.
    PATRICi 21880348. VBIExiSp39724_2521.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259588.
    KOi K00164.
    OMAi QHAPNKE.
    OrthoDBi EOG6V1M1F.

    Enzyme and pathway databases

    BioCyci ESP360911:GI4R-2634-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01169. SucA_OdhA.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1283 / AT1b.

    Entry informationi

    Entry nameiODO1_EXISA
    AccessioniPrimary (citable) accession number: C4L3W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3