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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciESP360911:GI4R-2634-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:EAT1b_2538
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000000716 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9519512-oxoglutarate dehydrogenase E1 componentPRO_1000213735Add
BLAST

Proteomic databases

PRIDEiC4L3W2.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi360911.EAT1b_2538.

Structurei

3D structure databases

ProteinModelPortaliC4L3W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

C4L3W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESSNVHEK SQAFYGPNLG YIIELYEQYL EDPSSVDEET RRYFDEFGAP
60 70 80 90 100
ETSTPTEVPV SGPSFDLEKV VSATRLINDI RAFGHKAADI YPLKDHPREQ
110 120 130 140 150
ELFELSRYDL TEEDLKQIPA RLLSDDAPKP NASALELFRH LLDVYTGTVA
160 170 180 190 200
IELRHLDDME EKKWIRRQVE QGALQQTFSK EEKIELFKRL AETELFESFL
210 220 230 240 250
HKTYVGQKRF SIEGLDAMVP LLDAMVGGLI SSGSEHINIG MAHRGRLNVL
260 270 280 290 300
AHVLGKPYEM IFAEFQHAPN KELIPSEGSI GINFGWSGDV KYHLGLDRKV
310 320 330 340 350
VEQQKEVRLN LANNPSHLEF VGSVVEGYTR AAQDDRSEKG SAVQHDDLAA
360 370 380 390 400
SILIHGDAAF PGQGIVAETL NMTNLTGYRT GGTVHVIANN TIGFTTDPND
410 420 430 440 450
SRSTRYASDI AKGYEIPVFH VNADDPEACV AVAKLISEYR AKFHKDILVD
460 470 480 490 500
LIGYRRYGHN EMDEPMNTNP VLYKAIKGHQ SVRHVYAARL EEEGVMTKDE
510 520 530 540 550
KAQIEQKIEE ALKAARDLVP SEEEDADIVL PDAVHKGFPK VDTSVEREFL
560 570 580 590 600
TQLNEELLNW PEGFGVFHKL QKVLDRRRDA FSEGGKIDWG HAETLAFASI
610 620 630 640 650
LSDGTPVRLS GQDSERGTFA QRNIMLNDVE SGKKFSPLHE LSTAKASFSV
660 670 680 690 700
YNSPLSEGSV LGFEYGYNVF AQDTLVLWEA QYGDFANSAQ VMFDQFISAG
710 720 730 740 750
RAKWGQKSGL VMLLPHGYEG QGPEHSSARM ERYLTLAGEK NWTVANLSSA
760 770 780 790 800
AQYFHILRRQ AEMLGKEEIR PMIIMTPKSL LRHPLATSPV EAFTEESFKP
810 820 830 840 850
IVEQPGLGEN TEKVERLVFC TGKMAIDLAE AVGKSEESLD FLHIVRVEEI
860 870 880 890 900
YPFPVREIRD VISRYPNARE IVWVQEEPKN MGAWTYIEPR LEAVTTNRLD
910 920 930 940 950
VRYIGRRRRS SPAEGNPTAH KQEQARIIRE ALSRDVVSSG AGTSTYQKDR

K
Length:951
Mass (Da):106,924
Last modified:July 7, 2009 - v1
Checksum:iBB172AC8134ADA9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ71457.1.
RefSeqiWP_015881016.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ71457; ACQ71457; EAT1b_2538.
KEGGieat:EAT1b_2538.
PATRICi21880348. VBIExiSp39724_2521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ71457.1.
RefSeqiWP_015881016.1. NC_012673.1.

3D structure databases

ProteinModelPortaliC4L3W2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360911.EAT1b_2538.

Proteomic databases

PRIDEiC4L3W2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ71457; ACQ71457; EAT1b_2538.
KEGGieat:EAT1b_2538.
PATRICi21880348. VBIExiSp39724_2521.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciESP360911:GI4R-2634-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1b.

Entry informationi

Entry nameiODO1_EXISA
AccessioniPrimary (citable) accession number: C4L3W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.