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Protein

DNA topoisomerase

Gene

EAT1b_0476

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Enzyme and pathway databases

BioCyciESP360911:GI4R-476-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseSAAS annotation (EC:5.99.1.2SAAS annotation)
Gene namesi
Ordered Locus Names:EAT1b_0476Imported
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)Imported
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
Proteomesi
  • UP000000716 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi360911.EAT1b_0476.

Structurei

3D structure databases

ProteinModelPortaliC4L3B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 140ToprimInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the type IA topoisomerase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108IYH. Bacteria.
COG0550. LUCA.
HOGENOMiHOG000086847.
KOiK03169.
OMAiMSRACAD.
OrthoDBiPOG091H028X.

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR005738. TopoIII.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 2 hits.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
TIGRFAMsiTIGR01056. topB. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4L3B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIIAEKPS QAQKLAAPYP SKKRKEEIEI SPCPRFPEGA IVVWAVGHLC
60 70 80 90 100
ELQEPSHYRP EWKSWKYEAL PIVPERFDYR ISKGKSKPFY AIKKWLHDRS
110 120 130 140 150
ITDVIIASDA EREGEAIVRL ILRLAGNKKP LARLWISSLT EQAVDRGFSQ
160 170 180 190 200
LLPGEQTIPY YHEAMSRACA DWLVGMNASR AYTTLLKTIG IEDVFSLGRV
210 220 230 240 250
QTPTLALIVN REREIKQFVP EPYFEVEATL AKGRGTFKAK YTFGKTTKLK
260 270 280 290 300
TREEADAVVK RASGTAIVKT IDKEEKIEQP PFWFSLSGLQ AEAGKRFGFG
310 320 330 340 350
AKKTLDIAQK LYTKGWISYP RTDSGFVTPD EATLFPQTKA RLLKSDAYAG
360 370 380 390 400
LRDLLTEDPS KNRRYVNAKK VSDHYAIIPT EACGDVTRLG GDEAKLYDLI
410 420 430 440 450
NRRFLAAFAP AAMLEKTTVD LIDGGDLYRA KGTVVVSPGY RQVVEMKSKD
460 470 480 490 500
VELPALTVGE EFKEKKVEVL SKQTEPPKRY TEGALIMAMK VAGKQLDDEE
510 520 530 540 550
LIHIMKEVEG LGTEATRANI IDGLKKRGYV QLQKKELVPT DKGRLLIDVL
560 570 580 590 600
GDSILASPVM TAKWEKRLHE IGQASASAAE FIEQAKKMSV HLVEEAKSRV
610 620 630 640 650
EAANPEGYTI EAKRYGKKGT TRPKASFGIC PNCGKGLVEH PKFIGCSGYR
660 670 680 690 700
EGCRFTVSKQ VLGVGLVKDE LKQMINGGQS NVHTFKKGDK TFNASLYLEK

GTLRFEFK
Length:708
Mass (Da):79,181
Last modified:July 7, 2009 - v1
Checksum:iE33F15DDA52F27E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ69408.1.
RefSeqiWP_012726527.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ69408; ACQ69408; EAT1b_0476.
KEGGieat:EAT1b_0476.
PATRICi21876044. VBIExiSp39724_0461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ69408.1.
RefSeqiWP_012726527.1. NC_012673.1.

3D structure databases

ProteinModelPortaliC4L3B0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360911.EAT1b_0476.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ69408; ACQ69408; EAT1b_0476.
KEGGieat:EAT1b_0476.
PATRICi21876044. VBIExiSp39724_0461.

Phylogenomic databases

eggNOGiENOG4108IYH. Bacteria.
COG0550. LUCA.
HOGENOMiHOG000086847.
KOiK03169.
OMAiMSRACAD.
OrthoDBiPOG091H028X.

Enzyme and pathway databases

BioCyciESP360911:GI4R-476-MONOMER.

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR005738. TopoIII.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 2 hits.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
TIGRFAMsiTIGR01056. topB. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC4L3B0_EXISA
AccessioniPrimary (citable) accession number: C4L3B0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: November 30, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.