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C4L367

- GSA1_EXISA

UniProt

C4L367 - GSA1_EXISA

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase 1
Gene
hemL1, EAT1b_2420
Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciESP360911:GI4R-2499-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 1 (EC:5.4.3.8)
Short name:
GSA 1
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 1
Short name:
GSA-AT 1
Gene namesi
Name:hemL1
Ordered Locus Names:EAT1b_2420
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000000716: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Glutamate-1-semialdehyde 2,1-aminomutase 1UniRule annotation
PRO_0000382315Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei272 – 2721N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi360911.EAT1b_2420.

Structurei

3D structure databases

ProteinModelPortaliC4L367.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiPVVMERA.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.

Sequencei

Sequence statusi: Complete.

C4L367-1 [UniParc]FASTAAdd to Basket

« Hide

MTTSSNRQSS DALYQDALTH IVGGVNSPSR SFKAVGGGAP VYMERGEGAY    50
FYDVDGNRYI DYLAAYGPII TGHAHPHIHE ALMNASSKGL LYGTPHRLEV 100
EFAKKLKQAI PSMDKVRFTN SGTEAVMTTV RVARAYTGRE LVVKFSGCYH 150
GHSDLMLIAA GSGPATLGSP DSAGVTKATA KEVITVPFND VEAYREMMKE 200
WGDQVACVLV EPIVGNFGIV EPKPGFLQAV NDITHEHGAL VIYDEVITAF 250
RFTYGSAQQV YGIEPDMTAL GKIIGGGLPI GAYGGKAEIM ETVAPLGPAY 300
QAGTMAGNPA SMATGIACLE VLEQPGVYEK LDALGAKLEA GIREAAEKHD 350
VTITLNRLKG ALTVYFTDEI VTDYEGAEKS DGEKFGRFFK LMLENGVNLA 400
PSKYEAWFLT TEHTEQDIEE TIEAVNRSFA QL 432
Length:432
Mass (Da):46,541
Last modified:July 7, 2009 - v1
Checksum:iA1F48ECC8D9C85E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001615 Genomic DNA. Translation: ACQ71341.1.
RefSeqiWP_015880900.1. NC_012673.1.
YP_002886786.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ71341; ACQ71341; EAT1b_2420.
GeneIDi7869977.
KEGGieat:EAT1b_2420.
PATRICi21880078. VBIExiSp39724_2403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001615 Genomic DNA. Translation: ACQ71341.1 .
RefSeqi WP_015880900.1. NC_012673.1.
YP_002886786.1. NC_012673.1.

3D structure databases

ProteinModelPortali C4L367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360911.EAT1b_2420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ71341 ; ACQ71341 ; EAT1b_2420 .
GeneIDi 7869977.
KEGGi eat:EAT1b_2420.
PATRICi 21880078. VBIExiSp39724_2403.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi PVVMERA.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci ESP360911:GI4R-2499-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1b.

Entry informationi

Entry nameiGSA1_EXISA
AccessioniPrimary (citable) accession number: C4L367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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