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C4L321

- C4L321_EXISA

UniProt

C4L321 - C4L321_EXISA

Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotationSAAS annotation

    Catalytic activityi

    Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 thiamine pyrophosphate per subunit.UniRule annotationSAAS annotation
    Magnesium or manganese.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Menaquinone biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Thiamine pyrophosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciESP360911:GI4R-2453-MONOMER.
    UniPathwayiUPA00079; UER00164.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
    Short name:
    SEPHCHC synthaseUniRule annotation
    Alternative name(s):
    Menaquinone biosynthesis protein MenDUniRule annotation
    Gene namesi
    Name:menDUniRule annotation
    Ordered Locus Names:EAT1b_2374Imported
    OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)Imported
    Taxonomic identifieri360911 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
    ProteomesiUP000000716: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi360911.EAT1b_2374.

    Structurei

    3D structure databases

    ProteinModelPortaliC4L321.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1165.
    HOGENOMiHOG000218359.
    KOiK02551.
    OMAiSMPVRDM.
    OrthoDBiEOG6NWBQW.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01659. MenD.
    InterProiIPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    [Graphical view]
    PfamiPF02776. TPP_enzyme_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004983. MenD. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00173. menD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4L321-1 [UniParc]FASTAAdd to Basket

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    MNKVLTEWVA SMVNRLVTSG VKDVVISPGS RSTPLAVAAY LHPQIRHHII    50
    VDERSAGFFA LGLTRASETV RPVALICTSG TAATNYYSAV TEAFISQLPL 100
    VVLTTDRPHE LRNVGAPQAI NQVRLYGEQV KTSVDLPVPE EATLSFMQQT 150
    ITRFTNLSMQ APMGPVHLNV PFREPLLPDI ESLKQILKAD PVLPERQRIR 200
    PTQADKDIFS ERTSHKQLAF VVGPYTPTSW QKSIVEYASE RQIPIFADPL 250
    SGMRRFDGVL TNYDTWLASE HRTDWLPEVF VRFGAAPVSK RFNQWMAMAD 300
    QLVIDEPGSY RDPSSRATIC YGDALDFLPL IASANEPRYL ERLRFFEEIA 350
    ESAKSSLQGE VELTKRLLDT SIELLFVSNS MPIRDVDISL SAGTNIHVLA 400
    NRGANGIDGV LSTALGSSYD TSHGALLIGD LAFYHDSNAL QLLKHHPGKF 450
    SVVIANNNGG GIFSFLPQAA VDTQLFEDLF GTPLDLNIRG FADTYGLTYR 500
    LIERPDEIQE AIEDGIHLIE FPSNREENVM IHRGWTQSVC SRLITENES 549
    Length:549
    Mass (Da):61,008
    Last modified:July 7, 2009 - v1
    Checksum:i78269CD75FC2CCEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001615 Genomic DNA. Translation: ACQ71295.1.
    RefSeqiWP_015880854.1. NC_012673.1.
    YP_002886740.1. NC_012673.1.

    Genome annotation databases

    EnsemblBacteriaiACQ71295; ACQ71295; EAT1b_2374.
    GeneIDi7870423.
    KEGGieat:EAT1b_2374.
    PATRICi21879986. VBIExiSp39724_2357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001615 Genomic DNA. Translation: ACQ71295.1 .
    RefSeqi WP_015880854.1. NC_012673.1.
    YP_002886740.1. NC_012673.1.

    3D structure databases

    ProteinModelPortali C4L321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360911.EAT1b_2374.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ71295 ; ACQ71295 ; EAT1b_2374 .
    GeneIDi 7870423.
    KEGGi eat:EAT1b_2374.
    PATRICi 21879986. VBIExiSp39724_2357.

    Phylogenomic databases

    eggNOGi COG1165.
    HOGENOMi HOG000218359.
    KOi K02551.
    OMAi SMPVRDM.
    OrthoDBi EOG6NWBQW.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00164 .
    BioCyci ESP360911:GI4R-2453-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01659. MenD.
    InterProi IPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    [Graphical view ]
    Pfami PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004983. MenD. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00173. menD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1283 / AT1bImported.

    Entry informationi

    Entry nameiC4L321_EXISA
    AccessioniPrimary (citable) accession number: C4L321
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3