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C4L321

- C4L321_EXISA

UniProt

C4L321 - C4L321_EXISA

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Protein
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
Gene
menD, EAT1b_2374
Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotationSAAS annotations

Cofactori

Binds 1 thiamine pyrophosphate per subunit By similarity.UniRule annotationSAAS annotations
Magnesium or manganese By similarity.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotations

Keywords - Biological processi

Menaquinone biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Thiamine pyrophosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciESP360911:GI4R-2453-MONOMER.
UniPathwayiUPA00079; UER00164.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
Short name:
SEPHCHC synthaseUniRule annotation
Alternative name(s):
Menaquinone biosynthesis protein MenD
Gene namesi
Name:menDUniRule annotation
Ordered Locus Names:EAT1b_2374Imported
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)Imported
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000000716: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi360911.EAT1b_2374.

Structurei

3D structure databases

ProteinModelPortaliC4L321.

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1165.
HOGENOMiHOG000218359.
KOiK02551.
OMAiSMPVRDM.
OrthoDBiEOG6NWBQW.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01659. MenD.
InterProiIPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
[Graphical view]
PfamiPF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004983. MenD. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00173. menD. 1 hit.

Sequencei

Sequence statusi: Complete.

C4L321-1 [UniParc]FASTAAdd to Basket

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MNKVLTEWVA SMVNRLVTSG VKDVVISPGS RSTPLAVAAY LHPQIRHHII    50
VDERSAGFFA LGLTRASETV RPVALICTSG TAATNYYSAV TEAFISQLPL 100
VVLTTDRPHE LRNVGAPQAI NQVRLYGEQV KTSVDLPVPE EATLSFMQQT 150
ITRFTNLSMQ APMGPVHLNV PFREPLLPDI ESLKQILKAD PVLPERQRIR 200
PTQADKDIFS ERTSHKQLAF VVGPYTPTSW QKSIVEYASE RQIPIFADPL 250
SGMRRFDGVL TNYDTWLASE HRTDWLPEVF VRFGAAPVSK RFNQWMAMAD 300
QLVIDEPGSY RDPSSRATIC YGDALDFLPL IASANEPRYL ERLRFFEEIA 350
ESAKSSLQGE VELTKRLLDT SIELLFVSNS MPIRDVDISL SAGTNIHVLA 400
NRGANGIDGV LSTALGSSYD TSHGALLIGD LAFYHDSNAL QLLKHHPGKF 450
SVVIANNNGG GIFSFLPQAA VDTQLFEDLF GTPLDLNIRG FADTYGLTYR 500
LIERPDEIQE AIEDGIHLIE FPSNREENVM IHRGWTQSVC SRLITENES 549
Length:549
Mass (Da):61,008
Last modified:July 7, 2009 - v1
Checksum:i78269CD75FC2CCEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001615 Genomic DNA. Translation: ACQ71295.1.
RefSeqiWP_015880854.1. NC_012673.1.
YP_002886740.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ71295; ACQ71295; EAT1b_2374.
GeneIDi7870423.
KEGGieat:EAT1b_2374.
PATRICi21879986. VBIExiSp39724_2357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001615 Genomic DNA. Translation: ACQ71295.1 .
RefSeqi WP_015880854.1. NC_012673.1.
YP_002886740.1. NC_012673.1.

3D structure databases

ProteinModelPortali C4L321.
ModBasei Search...

Protein-protein interaction databases

STRINGi 360911.EAT1b_2374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ71295 ; ACQ71295 ; EAT1b_2374 .
GeneIDi 7870423.
KEGGi eat:EAT1b_2374.
PATRICi 21879986. VBIExiSp39724_2357.

Phylogenomic databases

eggNOGi COG1165.
HOGENOMi HOG000218359.
KOi K02551.
OMAi SMPVRDM.
OrthoDBi EOG6NWBQW.

Enzyme and pathway databases

UniPathwayi UPA00079 ; UER00164 .
BioCyci ESP360911:GI4R-2453-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01659. MenD.
InterProi IPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
[Graphical view ]
Pfami PF02776. TPP_enzyme_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF004983. MenD. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00173. menD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1b.

Entry informationi

Entry nameiC4L321_EXISA
AccessioniPrimary (citable) accession number: C4L321
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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