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Protein

Glutaminase

Gene

glsA

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641SubstrateUniRule annotation
Binding sitei116 – 1161SubstrateUniRule annotation
Binding sitei163 – 1631SubstrateUniRule annotation
Binding sitei170 – 1701SubstrateUniRule annotation
Binding sitei194 – 1941SubstrateUniRule annotation
Binding sitei246 – 2461SubstrateUniRule annotation
Binding sitei264 – 2641Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciESP360911:GI4R-2327-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:EAT1b_2251
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000000716 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313GlutaminasePRO_1000205062Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi360911.EAT1b_2251.

Structurei

3D structure databases

ProteinModelPortaliC4L2C1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiTKQCAIE.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

C4L2C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLEQQLNH LVDECRPYTA QGKVADYIPE LAHVKNDLLG VAICLPDGTY
60 70 80 90 100
IHAGDVHHKF TIQSVSKALT LCYVLMEFGE DYVFSKVGME PTGDAFNSIA
110 120 130 140 150
KLEETVPSKP LNPMINAGAL AVTSMILGET AELKIYQFRQ FLATLLNRSV
160 170 180 190 200
EEVTYDEKVA RSEYETTDLN RALLYFMRHH GIVEGDVDEI IDVYTKQCAI
210 220 230 240 250
EIDCFDLARI GRVFAGNGED PDTGEELIPR RVVRIVKAIM TTCGMYDASG
260 270 280 290 300
EFAVRVGLPG KSGVSGAILA VGNHELDLNN VGFGIFGPAL DSKGNSIAGM
310
KLLELLIERY TSR
Length:313
Mass (Da):34,412
Last modified:July 7, 2009 - v1
Checksum:i04450E14AA9367DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ71173.1.
RefSeqiYP_002886618.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ71173; ACQ71173; EAT1b_2251.
KEGGieat:EAT1b_2251.
PATRICi21879720. VBIExiSp39724_2227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ71173.1.
RefSeqiYP_002886618.1. NC_012673.1.

3D structure databases

ProteinModelPortaliC4L2C1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360911.EAT1b_2251.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ71173; ACQ71173; EAT1b_2251.
KEGGieat:EAT1b_2251.
PATRICi21879720. VBIExiSp39724_2227.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiTKQCAIE.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciESP360911:GI4R-2327-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1b.

Entry informationi

Entry nameiGLSA_EXISA
AccessioniPrimary (citable) accession number: C4L2C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: April 1, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.