Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (EAT1b_2225)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciESP360911:GI4R-2302-MONOMER.
UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:EAT1b_2226
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
Proteomesi
  • UP000000716 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Phosphoribosylaminoimidazole-succinocarboxamide synthasePRO_1000203229Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360911.EAT1b_2226.

Structurei

3D structure databases

ProteinModelPortaliC4L296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8V. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiEOG62C9HN.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4L296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAIYEGKAK ALFETEEAGV LRVYYKDDAT AFNGEKKESI DGKGILNNAI
60 70 80 90 100
TTQLFELMHD NKIPTHFIKQ ISDREQLVRR VDIIPLEVVV RNVAAGSLAK
110 120 130 140 150
RLGWEEGTPL LAPIVEFYYK DDALGDPLLT EDHIRLLQVA THKEVETLRQ
160 170 180 190 200
LGLWVNDVLL DFFGQHGIDV IDFKLEFGKV DGTIILADEI SPDTCRLWDK
210 220 230
ETKQKLDKDV FRRDLGSLTE TYGQLLTRIG GNGQ
Length:234
Mass (Da):26,487
Last modified:July 7, 2009 - v1
Checksum:i9B73CC006A515968
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ71148.1.
RefSeqiWP_015880707.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ71148; ACQ71148; EAT1b_2226.
KEGGieat:EAT1b_2226.
PATRICi21879668. VBIExiSp39724_2201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ71148.1.
RefSeqiWP_015880707.1. NC_012673.1.

3D structure databases

ProteinModelPortaliC4L296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360911.EAT1b_2226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ71148; ACQ71148; EAT1b_2226.
KEGGieat:EAT1b_2226.
PATRICi21879668. VBIExiSp39724_2201.

Phylogenomic databases

eggNOGiENOG4105C8V. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiEOG62C9HN.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.
BioCyciESP360911:GI4R-2302-MONOMER.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1b.

Entry informationi

Entry nameiPUR7_EXISA
AccessioniPrimary (citable) accession number: C4L296
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: January 20, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.