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Protein

Ornithine carbamoyltransferase, catabolic

Gene

arcB

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotationSAAS annotation

Pathway:iL-arginine degradation via ADI pathway

This protein is involved in step 2 of the subpathway that synthesizes carbamoyl phosphate from L-arginine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Arginine deiminase (arcA), Arginine deiminase (arcA)
  2. Ornithine carbamoyltransferase, catabolic (arcB), Ornithine carbamoyltransferase, catabolic (arcB)
This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei31 – 311Important for structural integrityUniRule annotation
Binding sitei105 – 1051Carbamoyl phosphateUniRule annotation
Binding sitei132 – 1321Carbamoyl phosphateUniRule annotation
Sitei145 – 1451Important for structural integrityUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Arginine metabolismUniRule annotation

Enzyme and pathway databases

BioCyciESP360911:GI4R-2119-MONOMER.
UniPathwayiUPA00254; UER00365.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase, catabolicUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:arcBUniRule annotation
Ordered Locus Names:EAT1b_2070Imported
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)Imported
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000000716 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi360911.EAT1b_2070.

Structurei

3D structure databases

ProteinModelPortaliC4L130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 585Carbamoyl phosphate bindingUniRule annotation
Regioni266 – 2694Ornithine bindingUniRule annotation

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0078.
HOGENOMiHOG000022686.
KOiK00611.
OMAiGIMIRTY.
OrthoDBiEOG690MGV.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4L130-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKTIQHFL TMEELTPDTL DSLMQLAHEV KRSPQSYATA LTGKKVALLF
60 70 80 90 100
EKASTRTRMS FEVGVVELGG YPLFLSGQDL QIGRGEPLTD TIQVMSRYVD
110 120 130 140 150
ALMIRTYAHE TVETLAQHGS IPIINGLTDL HHPCQVLADL LTIEEQFGSR
160 170 180 190 200
AGKVLAYIGD GNNMAHSLMI GGALSGMHIR IASPNGYTVD HAIYEKAQKL
210 220 230 240 250
ATSTGGSIAL FENPSLAANE ADIVYTDVFA SMGQEGEAEE RLMKFNGFQV
260 270 280 290 300
NKELMALANP DAIFLHCLPA HRGEEVTADV IDGPQSWVFD QAENRLHAQK

ALMLTLLT
Length:308
Mass (Da):33,672
Last modified:July 7, 2009 - v1
Checksum:iC4F5365611E25102
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ70993.1.
RefSeqiWP_015880552.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ70993; ACQ70993; EAT1b_2070.
KEGGieat:EAT1b_2070.
PATRICi21879310. VBIExiSp39724_2049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ70993.1.
RefSeqiWP_015880552.1. NC_012673.1.

3D structure databases

ProteinModelPortaliC4L130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360911.EAT1b_2070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ70993; ACQ70993; EAT1b_2070.
KEGGieat:EAT1b_2070.
PATRICi21879310. VBIExiSp39724_2049.

Phylogenomic databases

eggNOGiCOG0078.
HOGENOMiHOG000022686.
KOiK00611.
OMAiGIMIRTY.
OrthoDBiEOG690MGV.

Enzyme and pathway databases

UniPathwayiUPA00254; UER00365.
BioCyciESP360911:GI4R-2119-MONOMER.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1bImported.

Entry informationi

Entry nameiC4L130_EXISA
AccessioniPrimary (citable) accession number: C4L130
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: July 22, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.