C4L0Z5 (SYR_EXISA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	EAT1b_2035

Organism

Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b) [Complete proteome] [HAMAP]

Taxonomic identifier

360911 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillales incertae sedis › Bacillales Family XII. Incertae Sedis › Exiguobacterium

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_1000203095
Regions
	Motif	121 – 131	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	C4L0Z5 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: 4740E3A6F126438A	FASTA	560	63,311
	10 20 30 40 50 60 MSYERKYAEA LSRVIGEELT IDQIEALIEK PKHEAHGDLA FPCFQLAKAY RKAPVMIATD 70 80 90 100 110 120 IANELNDELF TKVEAAGPYV NVFLSRDVVS KEIINTVLEE KSEYATHEAR NETIVTDFSS 130 140 150 160 170 180 PNIAKPFSMG HLRSTVIGNA INQIARKNGY DVVGVNHLGD WGTQFGKLMV AYKKWGDEEA 190 200 210 220 230 240 VRANPIAELL KLYVHFHEEA KTQPELEDEG RAWFKKLEDG DAEATELWQW FRDESLKEFQ 250 260 270 280 290 300 KVYDLLGVKF ESFNGEAFYN DKMGRVVEML EAKNLLVESE GAMVVSLEEE NLPPCLIKKK 310 320 330 340 350 360 DGATLYATRD LAAAIYRYET YNFVQANYVV GGEQALHFKQ LFSVLRKLGY DFVDGMHHVP 370 380 390 400 410 420 FGLILQEGKK MSTRKGRIVL LEEVLKEAIE KAQANIEQKN PDLANAQDVA RMVGVGAVVF 430 440 450 460 470 480 HDLKNERINN IEFDLDSMLK FEGETGPYVQ YTNARANSLL RKGNYDGSPF TGADDDYSWG 490 500 510 520 530 540 VVTMLNAFPH VITRAHERRE PSIISRYVLD LAQAFNKYYG HVRVLEEDAG KQSRLALVKA 550 560 VTLVLTEGLR LLGVEAPEEM

References

[1]

"Complete sequence of Exiguobacterium sp. AT1b." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G. , Ramaley R.F., Rodrigues D.F., Vishnivetskaya T.A., Kathariou S., Tiedje J.M., Richardson P. Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1283 / AT1b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001615 Genomic DNA. Translation: ACQ70958.1.
RefSeq	YP_002886403.1. NC_012673.1.
3D structure databases
ProteinModelPortal	C4L0Z5.
ModBase	Search...
Protein-protein interaction databases
STRING	360911.EAT1b_2035.
Proteomic databases
PRIDE	C4L0Z5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACQ70958; ACQ70958; EAT1b_2035.
GeneID	7868842.
KEGG	eat:EAT1b_2035.
PATRIC	21879240. VBIExiSp39724_2014.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247211.
KO	K01887.
OMA	CKSMLAW.
ProtClustDB	PRK12451.
Enzyme and pathway databases
BioCyc	ESP360911:GI4R-2084-MONOMER.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_EXISA

Accession

Primary (citable) accession number: C4L0Z5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program