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C4KZ55

- GCH4_EXISA

UniProt

C4KZ55 - GCH4_EXISA

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei183 – 1831May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciESP360911:GI4R-1447-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:EAT1b_1441
OrganismiExiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Taxonomic identifieri360911 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000000716: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303GTP cyclohydrolase FolE2PRO_1000215390Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360911.EAT1b_1441.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiAKWFFDR.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

C4KZ55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTSHVALPT KAERHKLFGS VPPIKGTKPT EKEQMVDLQN TPKNFLFALD
60 70 80 90 100
SVGISNVKHP VNVETPEGVQ STVATFELTT SLVQDRKGIN MSRLTEQLDA
110 120 130 140 150
YHQQGWTVSN RSLIEFAQEL AERMEQTEGQ LTIRYPWFFT RKAPATGLSG
160 170 180 190 200
LMNADVMHRV TYNLETGVAN VTVGLVINVT TLCPCSKEIS EYSAHNQRGY
210 220 230 240 250
ITIEAGLDET SMDGFDWRAA LLDAAESNAS APLHPVLKRP DEKRATEIAY
260 270 280 290 300
ENPRFVEDMV RLIAADLYEM KQVVNFFVEC RNEESIHQHD AIASITFDKR

QDA
Length:303
Mass (Da):33,959
Last modified:July 7, 2009 - v1
Checksum:i4DC671B653EB9A38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ70368.1.
RefSeqiWP_012727487.1. NC_012673.1.
YP_002885813.1. NC_012673.1.

Genome annotation databases

EnsemblBacteriaiACQ70368; ACQ70368; EAT1b_1441.
GeneIDi7869435.
KEGGieat:EAT1b_1441.
PATRICi21877974. VBIExiSp39724_1423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001615 Genomic DNA. Translation: ACQ70368.1 .
RefSeqi WP_012727487.1. NC_012673.1.
YP_002885813.1. NC_012673.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360911.EAT1b_1441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ70368 ; ACQ70368 ; EAT1b_1441 .
GeneIDi 7869435.
KEGGi eat:EAT1b_1441.
PATRICi 21877974. VBIExiSp39724_1423.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi AKWFFDR.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci ESP360911:GI4R-1447-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1283 / AT1b.

Entry informationi

Entry nameiGCH4_EXISA
AccessioniPrimary (citable) accession number: C4KZ55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3