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Protein
Submitted name:

Translation elongation factor Tu

Gene

tuf_1

Organism
Burkholderia pseudomallei MSHR346
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi81 – 855GTPUniRule annotation
Nucleotide bindingi136 – 1394GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPSE536230:GHVQ-3924-MONOMER.
BPSE536230:GHVQ-3941-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Translation elongation factor TuImported
Gene namesi
Name:tuf_1Imported
Synonyms:tufUniRule annotation, tuf_2Imported
ORF Names:GBP346_A3933Imported, GBP346_A3950Imported
OrganismiBurkholderia pseudomallei MSHR346Imported
Taxonomic identifieri536230 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002031 Componenti: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiC4KWX6.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi536230.GBP346_A3950.

Structurei

3D structure databases

ProteinModelPortaliC4KWX6.
SMRiC4KWX6. Positions 2-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4KWX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEKFERTK PHVNVGTIGH VDHGKTTLTA AIATVLSAKF GGEAKKYDEI
60 70 80 90 100
DAAPEEKARG ITINTAHIEY ETANRHYAHV DCPGHADYVK NMITGAAQMD
110 120 130 140 150
GAILVCSAAD GPMPQTREHI LLARQVGVPY IIVFLNKCDM VDDAELLELV
160 170 180 190 200
EMEVRELLSK YDFPGDDTPI IKGSAKLALE GDKGELGEVA IMNLADALDT
210 220 230 240 250
YIPTPERAVD GAFLMPVEDV FSISGRGTVV TGRVERGVIK VGEEIEIVGI
260 270 280 290 300
KATAKTTCTG VEMFRKLLDQ GQAGDNVGIL LRGTKREDVE RGQVLAKPGS
310 320 330 340 350
ITPHTHFTAE VYVLSKDEGG RHTPFFNNYR PQFYFRTTDV TGSIELPKDK
360 370 380 390
EMVMPGDNVS ITVKLIAPIA MEEGLRFAIR EGGRTVGAGV VAKIIE
Length:396
Mass (Da):42,991
Last modified:July 7, 2009 - v1
Checksum:i4A60D806CDFF494C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001408 Genomic DNA. Translation: ACQ95378.1.
CP001408 Genomic DNA. Translation: ACQ97805.1.
RefSeqiYP_002898598.1. NC_012695.1.
YP_002898614.1. NC_012695.1.

Genome annotation databases

EnsemblBacteriaiACQ95378; ACQ95378; GBP346_A3950.
ACQ97805; ACQ97805; GBP346_A3933.
KEGGibpr:GBP346_A3933.
bpr:GBP346_A3950.
PATRICi32576610. VBIBurPse130472_3599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001408 Genomic DNA. Translation: ACQ95378.1.
CP001408 Genomic DNA. Translation: ACQ97805.1.
RefSeqiYP_002898598.1. NC_012695.1.
YP_002898614.1. NC_012695.1.

3D structure databases

ProteinModelPortaliC4KWX6.
SMRiC4KWX6. Positions 2-395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi536230.GBP346_A3950.

Proteomic databases

PRIDEiC4KWX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ95378; ACQ95378; GBP346_A3950.
ACQ97805; ACQ97805; GBP346_A3933.
KEGGibpr:GBP346_A3933.
bpr:GBP346_A3950.
PATRICi32576610. VBIBurPse130472_3599.

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OrthoDBiEOG6R5C6X.

Enzyme and pathway databases

BioCyciBPSE536230:GHVQ-3924-MONOMER.
BPSE536230:GHVQ-3941-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Harkins D.M., Brinkac L.M., Rogers Y.C., Detter J.C., Munk A.C., Bruce D.C., Keim P., Sims D.R., Brettin T.S.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MSHR346Imported.

Entry informationi

Entry nameiC4KWX6_BURPE
AccessioniPrimary (citable) accession number: C4KWX6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: April 1, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.