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C4KWX6

- C4KWX6_BURPE

UniProt

C4KWX6 - C4KWX6_BURPE

Protein

Elongation factor Tu

Gene

tuf_1

Organism
Burkholderia pseudomallei MSHR346
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268GTPUniRule annotation
    Nucleotide bindingi81 – 855GTPUniRule annotation
    Nucleotide bindingi136 – 1394GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factorUniRule annotationImported

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPSE536230:GHVQ-3924-MONOMER.
    BPSE536230:GHVQ-3941-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tuf_1Imported
    Synonyms:tufUniRule annotation, tuf_2Imported
    ORF Names:GBP346_A3933Imported, GBP346_A3950Imported
    OrganismiBurkholderia pseudomallei MSHR346Imported
    Taxonomic identifieri536230 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002031: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi536230.GBP346_A3950.

    Structurei

    3D structure databases

    SMRiC4KWX6. Positions 2-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.UniRule annotation
    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0050.
    HOGENOMiHOG000229290.
    KOiK02358.
    OrthoDBiEOG6R5C6X.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. EFACTOR_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4KWX6-1 [UniParc]FASTAAdd to Basket

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    MAKEKFERTK PHVNVGTIGH VDHGKTTLTA AIATVLSAKF GGEAKKYDEI    50
    DAAPEEKARG ITINTAHIEY ETANRHYAHV DCPGHADYVK NMITGAAQMD 100
    GAILVCSAAD GPMPQTREHI LLARQVGVPY IIVFLNKCDM VDDAELLELV 150
    EMEVRELLSK YDFPGDDTPI IKGSAKLALE GDKGELGEVA IMNLADALDT 200
    YIPTPERAVD GAFLMPVEDV FSISGRGTVV TGRVERGVIK VGEEIEIVGI 250
    KATAKTTCTG VEMFRKLLDQ GQAGDNVGIL LRGTKREDVE RGQVLAKPGS 300
    ITPHTHFTAE VYVLSKDEGG RHTPFFNNYR PQFYFRTTDV TGSIELPKDK 350
    EMVMPGDNVS ITVKLIAPIA MEEGLRFAIR EGGRTVGAGV VAKIIE 396
    Length:396
    Mass (Da):42,991
    Last modified:July 7, 2009 - v1
    Checksum:i4A60D806CDFF494C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001408 Genomic DNA. Translation: ACQ95378.1.
    CP001408 Genomic DNA. Translation: ACQ97805.1.
    RefSeqiYP_002898598.1. NC_012695.1.
    YP_002898614.1. NC_012695.1.

    Genome annotation databases

    EnsemblBacteriaiACQ95378; ACQ95378; GBP346_A3950.
    ACQ97805; ACQ97805; GBP346_A3933.
    GeneIDi7888392.
    7889211.
    KEGGibpr:GBP346_A3933.
    bpr:GBP346_A3950.
    PATRICi32576610. VBIBurPse130472_3599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001408 Genomic DNA. Translation: ACQ95378.1 .
    CP001408 Genomic DNA. Translation: ACQ97805.1 .
    RefSeqi YP_002898598.1. NC_012695.1.
    YP_002898614.1. NC_012695.1.

    3D structure databases

    SMRi C4KWX6. Positions 2-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 536230.GBP346_A3950.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ95378 ; ACQ95378 ; GBP346_A3950 .
    ACQ97805 ; ACQ97805 ; GBP346_A3933 .
    GeneIDi 7888392.
    7889211.
    KEGGi bpr:GBP346_A3933.
    bpr:GBP346_A3950.
    PATRICi 32576610. VBIBurPse130472_3599.

    Phylogenomic databases

    eggNOGi COG0050.
    HOGENOMi HOG000229290.
    KOi K02358.
    OrthoDBi EOG6R5C6X.

    Enzyme and pathway databases

    BioCyci BPSE536230:GHVQ-3924-MONOMER.
    BPSE536230:GHVQ-3941-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. EFACTOR_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Harkins D.M., Brinkac L.M., Rogers Y.C., Detter J.C., Munk A.C., Bruce D.C., Keim P., Sims D.R., Brettin T.S.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MSHR346Imported.

    Entry informationi

    Entry nameiC4KWX6_BURPE
    AccessioniPrimary (citable) accession number: C4KWX6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3