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C4KRM8

- C4KRM8_BURPE

UniProt

C4KRM8 - C4KRM8_BURPE

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Protein
Kynureninase
Gene
kynU, GBP346_A0820
Organism
Burkholderia pseudomallei MSHR346
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei97 – 971Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei98 – 981Pyridoxal phosphate By similarityUniRule annotation
Binding sitei172 – 1721Pyridoxal phosphate By similarityUniRule annotation
Binding sitei201 – 2011Pyridoxal phosphate By similarityUniRule annotation
Binding sitei204 – 2041Pyridoxal phosphate By similarityUniRule annotation
Binding sitei226 – 2261Pyridoxal phosphate By similarityUniRule annotation
Binding sitei256 – 2561Pyridoxal phosphate By similarityUniRule annotation
Binding sitei282 – 2821Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciBPSE536230:GHVQ-819-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotationImported
ORF Names:GBP346_A0820Imported
OrganismiBurkholderia pseudomallei MSHR346Imported
Taxonomic identifieri536230 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002031: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei227 – 2271N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi536230.GBP346_A0820.

Structurei

3D structure databases

ProteinModelPortaliC4KRM8.
SMRiC4KRM8. Positions 3-404.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1324Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242437.
KOiK01556.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

C4KRM8-1 [UniParc]FASTAAdd to Basket

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MKTREEALAL DRDDPLAPLR EQFALPAGVI YLDGNSLGAQ PRAAAARAQQ    50
VIGAEWGEGL IRSWNTAGWF ALPRRLGDRL APLIGAADGE VAITDTISIN 100
LFKLLAAMLR HQARHAPKRR VIVSERSNFP TDLYIAQGLI AQLDRDYELR 150
LIDDPADLPD ALDDETAVAM ITHVNYRTGY MHDMPSVTQT VRQAGALMLW 200
DLAHSAGAVP VDLNGALADG AVGCTYKYLN GGPGSPAFVW VPKRHQRAFE 250
QPLSGWWGHR APFAMQPAFE PDPGIARFLC GTQPIVSMSM VECGLDVFAQ 300
TDMHAIRRKS LALTDAFVAL VESRCAGQPL KLVTPRAHHQ RGSQASFEHP 350
HGYEVMQALI ARGVIGDYRE PRILRFGFTP LYTRFVDVWD AVETLRDILD 400
TEAWRAPEFA TRAAVT 416
Length:416
Mass (Da):45,864
Last modified:July 7, 2009 - v1
Checksum:iE48940B4AB277FB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001408 Genomic DNA. Translation: ACQ95775.1.
RefSeqiYP_002895544.1. NC_012695.1.

Genome annotation databases

EnsemblBacteriaiACQ95775; ACQ95775; GBP346_A0820.
GeneIDi7889100.
KEGGibpr:GBP346_A0820.
PATRICi32570831. VBIBurPse130472_0755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001408 Genomic DNA. Translation: ACQ95775.1 .
RefSeqi YP_002895544.1. NC_012695.1.

3D structure databases

ProteinModelPortali C4KRM8.
SMRi C4KRM8. Positions 3-404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 536230.GBP346_A0820.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ95775 ; ACQ95775 ; GBP346_A0820 .
GeneIDi 7889100.
KEGGi bpr:GBP346_A0820.
PATRICi 32570831. VBIBurPse130472_0755.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242437.
KOi K01556.
OrthoDBi EOG6N67XP.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci BPSE536230:GHVQ-819-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Harkins D.M., Brinkac L.M., Rogers Y.C., Detter J.C., Munk A.C., Bruce D.C., Keim P., Sims D.R., Brettin T.S.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MSHR346Imported.

Entry informationi

Entry nameiC4KRM8_BURPE
AccessioniPrimary (citable) accession number: C4KRM8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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