C4KHT9 (ILVC_SULIK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86

Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	M164_1552

Organism

Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) [Complete proteome] [HAMAP]

Taxonomic identifier

426118 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Ketol-acid reductoisomerase HAMAP MF_00435		PRO_1000206089
Sites
	Active site	111	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	C4KHT9 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: E3DA08CD10A30703	FASTA	335	36,847
	10 20 30 40 50 60 MKSTSKIYTD KDSNLDVIKG KRIAVLGYGS QGRAWAQNLR DSGLNVVVGL EREGKSWELA 70 80 90 100 110 120 KSDGIIPLHT KDAVKDADII IFLVPDMVQR TLWLESVQPY MKKGADLVFA HGFNIHYKLI 130 140 150 160 170 180 EPPKDSDVYM IAPKGPGPTV REYYKAGGGV PALVAIQQDV SGTALQKALA IAKGIGATRA 190 200 210 220 230 240 GVIPTTFKEE TETDLFGEQV ILVGGIMELM KAAFETLVEE GYQPEVAYFE TINELKMLVD 250 260 270 280 290 300 LVYEKGITGM LKAVSDTAKY GGMTVGKFVI NEDVRKRMKE ALQRIKSGKF AEEWVEEYGR 310 320 330 GMPTVVNGLS QVQNSLEEKI GNQLKDLIQK GKPKS

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed: 19435847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: M.16.4 / Kamchatka #3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001402 Genomic DNA. Translation: ACR42153.1.
RefSeq	YP_002914821.1. NC_012726.1.
3D structure databases
ProteinModelPortal	C4KHT9.
ModBase	Search...
Protein-protein interaction databases
STRING	C4KHT9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7940906.
GenomeReviews	Gene locus M164_1552 in contig CP001402_GR.
KEGG	sid:M164_1552.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAYAKGI.
ProtClustDB	PRK05479.
Family and domain databases
HAMAP	MF_00435. IlvC. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00053.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00465. IlvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_SULIK

Accession

Primary (citable) accession number: C4KHT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 7, 2009
Last modified:	November 16, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program