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C4KH41

- OGG1_SULIK

UniProt

C4KH41 - OGG1_SULIK

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Protein
Probable N-glycosylase/DNA lyase
Gene
ogg, M164_1300
Organism
Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281 By similarity

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciSISL426118:GI01-1331-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:M164_1300
OrganismiSulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Taxonomic identifieri426118 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001479: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Probable N-glycosylase/DNA lyaseUniRule annotation
PRO_1000204470Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi426118.M164_1300.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
KOiK03653.
OMAiLDLYLWY.

Family and domain databases

Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

C4KH41-1 [UniParc]FASTAAdd to Basket

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MLRSLVQNPR VRARVLERVD EFRLNNLSNE EVWFRELTLC LLTANSSFIS    50
AYQALNCLGD KIYYANEEVI RSILKSCKYR FYNLKAKYII MAREKVYGKL 100
KEEITPLADS DQQLAREKLL NIKGIGMKEA SHFLRNVGYF DLAIIDRHLI 150
DFMRRIGAIG ETNVKHLSKS RYISLESVLK SIALNLNISV GILDLFIWYK 200
ETNTIVK 207
Length:207
Mass (Da):24,071
Last modified:July 7, 2009 - v1
Checksum:iD56EDB4A5C5A4562
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001402 Genomic DNA. Translation: ACR41905.1.
RefSeqiYP_002914573.1. NC_012726.1.

Genome annotation databases

EnsemblBacteriaiACR41905; ACR41905; M164_1300.
GeneIDi7941050.
KEGGisid:M164_1300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001402 Genomic DNA. Translation: ACR41905.1 .
RefSeqi YP_002914573.1. NC_012726.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 426118.M164_1300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR41905 ; ACR41905 ; M164_1300 .
GeneIDi 7941050.
KEGGi sid:M164_1300.

Phylogenomic databases

eggNOGi COG1059.
HOGENOMi HOG000224507.
KOi K03653.
OMAi LDLYLWY.

Enzyme and pathway databases

BioCyci SISL426118:GI01-1331-MONOMER.

Family and domain databases

Gene3Di 1.10.340.30. 1 hit.
HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
Pfami PF00730. HhH-GPD. 1 hit.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M.16.4 / Kamchatka #3.

Entry informationi

Entry nameiOGG1_SULIK
AccessioniPrimary (citable) accession number: C4KH41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: May 14, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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