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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:M164_1287
OrganismiSulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Taxonomic identifieri426118 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001479 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002126741 – 509Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiC4KH28

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC4KH28
SMRiC4KH28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG093Z01WJ

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

C4KH28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWRQAKWDE PLIFELNNSG ANRQGLLINK DDEIRSEIKE MKIPKNLLRE
60 70 80 90 100
NGPNLPSLSE LEVVRHFIRL SQMNFGVDVG IMPLGSCTMK YNPKIEEKAT
110 120 130 140 150
AITESHHPLE DEDHVQGILE MIYELQNWFS EITGMDECSL QVPAGSAGEF
160 170 180 190 200
AGVLMIKKYH EDHNRNYKDT MLVADTAHGT NPASAAMAGY KVMYVKSNGE
210 220 230 240 250
GLVDMDILRE IVNDKTAGFM LTNPNTLGLF EENILEISKI IHSANAILYY
260 270 280 290 300
DGANLNGVLG IARPGDMGFD IVHLNLHKTF AVPHGGGGPG AGAICAKGEL
310 320 330 340 350
VNYLPYPMVE KVNGKYRLSK IPKNSVGKIA TFYGNVGNLA RSFAYLLGLG
360 370 380 390 400
PQGVQMVGKM STLATNYLIA KLRDIKELEL IAPNRHRKHE VVFSVKQLME
410 420 430 440 450
NYGVSANDVA KALLDSGFYA PTIYFPPIIE EALMIEPTET ESKETLDMFA
460 470 480 490 500
EALKKIVEDA KRNPEQLLKS PSNTSIARLD QAYANHPSTI TPTYRVLKLR

RMGKINYLK
Length:509
Mass (Da):56,584
Last modified:July 7, 2009 - v1
Checksum:i2181A9B4FA39ABD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001402 Genomic DNA Translation: ACR41892.1

Genome annotation databases

EnsemblBacteriaiACR41892; ACR41892; M164_1287
KEGGisid:M164_1287

Similar proteinsi

Entry informationi

Entry nameiGCSPB_SULIK
AccessioniPrimary (citable) accession number: C4KH28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health