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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:M164_1286
OrganismiSulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Taxonomic identifieri426118 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001479 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002126651 – 455Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST455

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC4KH27
SMRiC4KH27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG093Z02N9

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

C4KH27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKHPWLPNL DLIDEMLKEI GVNSLDELFN DIPAEIKINR LLNVAKGKPL
60 70 80 90 100
SEYEIEKEIN EKVKKNVELQ APPFIGAGIC PHYIPNVVKF IIGRSEFYTS
110 120 130 140 150
YTPYQPEISQ GLLQALFEYQ SLMAELLDMD VVNASMYDWG SALAEAVLMA
160 170 180 190 200
NRINGKKTVL VPENANPFHK EVVRTWIGGK GIKIEEVKYD KNSGELDLED
210 220 230 240 250
LEKKSNIDDI SAIYIQQPNF FGIFESNIEH VIDVAKHKRA LSIVGVNPLS
260 270 280 290 300
LGLIKPPGSY EADIVVGDGQ ELGLPLNFGG PLMGVFAVRW DMSLVRQMPG
310 320 330 340 350
RIVGITKDTN GKMGFTLILQ TREQFIKREK ATSNITTNEA LLAIANAVYL
360 370 380 390 400
SLLGKEGMRE LAEEIYFRSH YAAKKLTEID NVSMPFRSDF FEEFAIRFPI
410 420 430 440 450
EYDKISNKLK ERKLQGGLKL SDYTSLFCVT EVHDKKSIDL LVSTIQEMIN

GVETS
Length:455
Mass (Da):51,276
Last modified:July 7, 2009 - v1
Checksum:iE7A42776D179E532
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001402 Genomic DNA Translation: ACR41891.1

Genome annotation databases

EnsemblBacteriaiACR41891; ACR41891; M164_1286
KEGGisid:M164_1286

Similar proteinsi

Entry informationi

Entry nameiGCSPA_SULIK
AccessioniPrimary (citable) accession number: C4KH27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: April 25, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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