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Protein

Probable deoxyhypusine synthase

Gene

dys

Organism
Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.UniRule annotation

Catalytic activityi

[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.UniRule annotation

Cofactori

NAD+UniRule annotation

Pathwayi: eIF5A hypusination

This protein is involved in the pathway eIF5A hypusination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway eIF5A hypusination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei285NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processHypusine biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00354

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyhypusine synthaseUniRule annotation (EC:2.5.1.46UniRule annotation)
Short name:
DHSUniRule annotation
Gene namesi
Name:dysUniRule annotation
Ordered Locus Names:M164_1240
OrganismiSulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Taxonomic identifieri426118 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001479 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002034451 – 312Probable deoxyhypusine synthaseAdd BLAST312

Structurei

3D structure databases

SMRiC4KGY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the deoxyhypusine synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228838
KOiK00809
OMAiGWEDSTM
OrthoDBiPOG093Z05UK

Family and domain databases

Gene3Di3.40.910.10, 1 hit
HAMAPiMF_00153 DHS, 1 hit
InterProiView protein in InterPro
IPR022899 Deoxyhypus_synthase_arc
IPR002773 Deoxyhypusine_synthase
IPR036982 Deoxyhypusine_synthase_sf
IPR029035 DHS-like_NAD/FAD-binding_dom
PANTHERiPTHR11703 PTHR11703, 1 hit
PfamiView protein in Pfam
PF01916 DS, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit

Sequencei

Sequence statusi: Complete.

C4KGY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINREDLLKN PVEDIALRDL EKYSDIVNVF DKIYGFSSEG IVRGSKILKE
60 70 80 90 100
MIKDADLRFL SFTANLVSTG LRGLFADLVK RGYFNIIVTT GGTIDHDLAR
110 120 130 140 150
SFGGVYYKGS FDIDDAMLKD LEIHRLGNVL VPFESYGKVI EEIVRKFLPE
160 170 180 190 200
IAKDKKEIPA YELLWEFGKR ISDSNSILRA AYEKKVPVIV PGIVDGSFGT
210 220 230 240 250
NLFIQSQFLN FKINLFEDMR LIKDLVFSCK KSGALIIGGG ISKHHTIWWN
260 270 280 290 300
QFKDGLDYAV YVTTAQEYDG SLSGAKPREA ISWNKIRPNA KHATIYGDAT
310
IIVPILAASL LS
Length:312
Mass (Da):35,015
Last modified:July 7, 2009 - v1
Checksum:i41687DA3A7CBA68B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001402 Genomic DNA Translation: ACR41844.1

Genome annotation databases

EnsemblBacteriaiACR41844; ACR41844; M164_1240
KEGGisid:M164_1240

Similar proteinsi

Entry informationi

Entry nameiDHYS_SULIK
AccessioniPrimary (citable) accession number: C4KGY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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