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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79UniRule annotation1
Active sitei142UniRule annotation1
Active sitei164UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:M164_0533
OrganismiSulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Taxonomic identifieri426118 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002060251 – 209Pyrrolidone-carboxylate peptidaseAdd BLAST209

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC4KEG7
SMRiC4KEG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242641
KOiK01304
OMAiHHIATRA
OrthoDBiPOG093Z0BJN

Family and domain databases

CDDicd00501 Peptidase_C15, 1 hit
Gene3Di3.40.630.20, 1 hit
HAMAPiMF_00417 Pyrrolid_peptidase, 1 hit
InterProiView protein in InterPro
IPR000816 Peptidase_C15
IPR016125 Peptidase_C15-like
IPR036440 Peptidase_C15-like_sf
IPR029762 PGP-I_bact-type
IPR033694 PGPEP1_Cys_AS
IPR033693 PGPEP1_Glu_AS
PANTHERiPTHR23402 PTHR23402, 1 hit
PfamiView protein in Pfam
PF01470 Peptidase_C15, 1 hit
PIRSFiPIRSF015592 Prld-crbxl_pptds, 1 hit
PRINTSiPR00706 PYROGLUPTASE
SUPFAMiSSF53182 SSF53182, 1 hit
PROSITEiView protein in PROSITE
PS01334 PYRASE_CYS, 1 hit
PS01333 PYRASE_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

C4KEG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVLLFGFEP FLEYKENPSQ LIVEALNGST ILKEEVKGVI LPVEYEKIED
60 70 80 90 100
LIVTKIREMK PILTLGIGVA PGRAKITPEK IAINYKYSRE GDNAGKKYKG
110 120 130 140 150
EKIDPLGQDG IFTNIPVEDL VDLLNENGIP AELSLSAGSY LCNNAMYIII
160 170 180 190 200
REARKYNSLG GFIHVPLHES YAARIQRPIP SMSLDTMIRG IRLSMEFILT

NKKENLTFS
Length:209
Mass (Da):23,404
Last modified:July 7, 2009 - v1
Checksum:iAAE205344FD024B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001402 Genomic DNA Translation: ACR41164.1

Genome annotation databases

EnsemblBacteriaiACR41164; ACR41164; M164_0533
KEGGisid:M164_0533

Entry informationi

Entry nameiPCP_SULIK
AccessioniPrimary (citable) accession number: C4KEG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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