C4KEG7 (PCP_SULIK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrrolidone-carboxylate peptidase
EC=3.4.19.3

Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name=PGP-I
Short name=Pyrase

Gene names

Name:	pcp
Ordered Locus Names:	M164_0533

Organism

Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) [Complete proteome] [HAMAP]

Taxonomic identifier

426118 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus islandicus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity. HAMAP-Rule MF_00417
Catalytic activity	Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. HAMAP-Rule MF_00417
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00417
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00417.
Sequence similarities	Belongs to the peptidase C15 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW pyroglutamyl-peptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Pyrrolidone-carboxylate peptidase HAMAP-Rule MF_00417		PRO_1000206025
Sites
	Active site	79	1	By similarity
	Active site	142	1	By similarity
	Active site	164	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	C4KEG7 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: AAE205344FD024B7	FASTA	209	23,404
	10 20 30 40 50 60 MTVLLFGFEP FLEYKENPSQ LIVEALNGST ILKEEVKGVI LPVEYEKIED LIVTKIREMK 70 80 90 100 110 120 PILTLGIGVA PGRAKITPEK IAINYKYSRE GDNAGKKYKG EKIDPLGQDG IFTNIPVEDL 130 140 150 160 170 180 VDLLNENGIP AELSLSAGSY LCNNAMYIII REARKYNSLG GFIHVPLHES YAARIQRPIP 190 200 SMSLDTMIRG IRLSMEFILT NKKENLTFS

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: M.16.4 / Kamchatka #3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001402 Genomic DNA. Translation: ACR41164.1.
RefSeq	YP_002913832.1. NC_012726.1.
3D structure databases
ProteinModelPortal	C4KEG7.
ModBase	Search...
Protein-protein interaction databases
STRING	426118.M164_0533.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACR41164; ACR41164; M164_0533.
GeneID	7941403.
KEGG	sid:M164_0533.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2039.
HOGENOM	HOG000242641.
KO	K01304.
OMA	AYFTQLP.
ProtClustDB	PRK13193.
Enzyme and pathway databases
BioCyc	SISL426118:GI01-545-MONOMER.
Family and domain databases
Gene3D	3.40.630.20. 1 hit.
HAMAP	MF_00417. Pyrrolid_peptidase.
InterPro	IPR000816. Peptidase_C15. IPR016125. Peptidase_C15-like. [Graphical view]
PANTHER	PTHR23402. PTHR23402. 1 hit.
Pfam	PF01470. Peptidase_C15. 1 hit. [Graphical view]
PIRSF	PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTS	PR00706. PYROGLUPTASE.
SUPFAM	SSF53182. Peptidase_C15-like. 1 hit.
PROSITE	PS01334. PYRASE_CYS. 1 hit. PS01333. PYRASE_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PCP_SULIK

Accession

Primary (citable) accession number: C4KEG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 7, 2009
Last modified:	May 29, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program