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C4KCS1 (C4KCS1_THASP) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Tmz1t_3425 EMBL ACR02019.1
OrganismThauera sp. (strain MZ1T) [Complete proteome] [HAMAP] EMBL ACR02019.1
Taxonomic identifier85643 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeThauera

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain104 – 299196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding130 – 18556ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2531Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2661Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2661Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2681Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C4KCS1 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: 8B8DF3B5FCF5F3EC

FASTA30432,670
        10         20         30         40         50         60 
MKARFGKVAV LFGGSSAERE VSLMSGAAVL AALQAAGVDA HAFDPAERDL HVLKEEGFER 

        70         80         90        100        110        120 
AFIALHGRGG EDGTVQGALE LMGIPYTGSG VMASALSMDK WRTKMVWLSA GLPTPRYAIL 

       130        140        150        160        170        180 
EHDSDWDAVV AELGLPIFVK PVHEGSSMGA TKVVEAGQLR AAWELAARYD RLVIAEEFIC 

       190        200        210        220        230        240 
GAELTAPFLE DRALPLVRIV APGGNYDYQH KYFTDDTRYD CPSGLPAAQE AELQAMVMKC 

       250        260        270        280        290        300 
ARVLGCRGWG RADLILTEDG RPYLLEMNTS PGMTGHSLVP MSARVAGLDF TALCLEILQG 


ARLG 

« Hide

References

[1]"Complete sequence of chromosome of Thauera sp. MZ1T."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sayler G.S.
Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MZ1T.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001281 Genomic DNA. Translation: ACR02019.1.
RefSeqYP_002890396.1. NC_011662.2.

3D structure databases

ProteinModelPortalC4KCS1.
SMRC4KCS1. Positions 6-301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85643.Tmz1t_3425.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR02019; ACR02019; Tmz1t_3425.
GeneID7873916.
KEGGtmz:Tmz1t_3425.
PATRIC23883016. VBIThaSp83776_3339.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAWATKLVA.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycTSP85643:GHEJ-3386-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC4KCS1_THASP
AccessionPrimary (citable) accession number: C4KCS1
Entry history
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)