ID   C4K9V5_THASP            Unreviewed;       435 AA.
AC   C4K9V5; A0A5C7SRG0;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE            EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN   OrderedLocusNames=Tmz1t_2579 {ECO:0000313|EMBL:ACR01181.1};
GN   ORFNames=E6Q80_09255 {ECO:0000313|EMBL:TXH85686.1};
OS   Thauera aminoaromatica.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC   Thauera.
OX   NCBI_TaxID=164330 {ECO:0000313|EMBL:ACR01181.1, ECO:0000313|Proteomes:UP000002186};
RN   [1] {ECO:0000313|Proteomes:UP000002186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MZ1T {ECO:0000313|Proteomes:UP000002186};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sayler G.S.;
RT   "Complete sequence of chromosome of Thauera sp. MZ1T.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACR01181.1, ECO:0000313|Proteomes:UP000002186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MZ1T {ECO:0000313|EMBL:ACR01181.1,
RC   ECO:0000313|Proteomes:UP000002186};
RX   PubMed=23407619; DOI=10.4056/sigs.2696029;
RA   Jiang K., Sanseverino J., Chauhan A., Lucas S., Copeland A., Lapidus A.,
RA   Del Rio T.G., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D.,
RA   Brettin T., Detter J.C., Han C., Chang Y.J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N.C., Mikhailova N., Moser S., Jegier P., Close D.,
RA   Debruyn J.M., Wang Y., Layton A.C., Allen M.S., Sayler G.S.;
RT   "Complete genome sequence of Thauera aminoaromatica strain MZ1T.";
RL   Stand. Genomic Sci. 6:325-335(2012).
RN   [3] {ECO:0000313|EMBL:TXH85686.1, ECO:0000313|Proteomes:UP000321192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bin_27_1 {ECO:0000313|EMBL:TXH85686.1};
RA   Stamps B.W., Spear J.R.;
RT   "Metagenome Assembled Genomes from an Advanced Water Purification
RT   Facility.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|ARBA:ARBA00007441}.
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DR   EMBL; CP001281; ACR01181.1; -; Genomic_DNA.
DR   EMBL; SSFD01000136; TXH85686.1; -; Genomic_DNA.
DR   RefSeq; WP_004304070.1; NZ_SSFD01000136.1.
DR   AlphaFoldDB; C4K9V5; -.
DR   STRING; 85643.Tmz1t_2579; -.
DR   KEGG; tmz:Tmz1t_2579; -.
DR   eggNOG; COG0436; Bacteria.
DR   HOGENOM; CLU_017584_4_2_4; -.
DR   OrthoDB; 9803354at2; -.
DR   Proteomes; UP000002186; Chromosome.
DR   Proteomes; UP000321192; Unassembled WGS sequence.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR43488; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   PANTHER; PTHR43488:SF2; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:ACR01181.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002186};
KW   Transferase {ECO:0000313|EMBL:ACR01181.1}.
FT   DOMAIN          61..422
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   435 AA;  48242 MW;  2B282140E40B0AC0 CRC64;
     MKAVKTLELA AASPEPVIKA EAGAAAAPRP IRKSAKLAEV CYDIRGPVLV RAKQMEDEGH
     KIIKLNIGNL AAFGFDSPEE IQMDMIRNLP NAAGYSDSKG IFSARKAVMH YTQQKGIKGV
     TIEDIYIGNG VSELIVMAMN ALLDAGDEVL VPAPDYPLWT AAVSLSGGKP VHYLCDESKG
     WLPDIDDMRA KINANTRAIV VINPNNPTGA VYPDETLKQI VALAREHDLI LYADEVYDKV
     LYEGVRHTSM AALSEDVLTI IFNGLSKNYR SCGYRAGWMV VCGDKRRAND YIEGLNMLAS
     MRLCANVPGQ YAIQTALGGY QSIDDLVAEG GRMRRQRDLA WELINQIPGV SCVKPQATLY
     MFPRLDPKVY PIEDDQAFIA ELLEEERVLL VQGSGFNWPH PDHFRLVFLP HEDDLRDAIG
     RIARFLENYR KRHGT
//