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C4K8Y6

- DUT_HAMD5

UniProt

C4K8Y6 - DUT_HAMD5

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei83 – 831SubstrateUniRule annotation
    Binding sitei97 – 971Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciHDEF572265:GJAB-2340-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:HDEF_2318
    OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
    Taxonomic identifieri572265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
    ProteomesiUP000002334: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 151151Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_1000202985Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi572265.HDEF_2318.

    Structurei

    3D structure databases

    ProteinModelPortaliC4K8Y6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni70 – 723Substrate bindingUniRule annotation
    Regioni87 – 893Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dUTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0756.
    KOiK01520.
    OMAiSIYIGDP.
    OrthoDBiEOG689HXK.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00116. dUTPase_bact.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4K8Y6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIDIKILD KRIGDVFPLP TYTTSGSAGL DLRVCTQAPQ HLSPGETRLL    50
    PTGLAVHIAD PHLAAMILPR SGLGHKNGIV LGNLVGLIDS DYQGELMLSV 100
    WNRSQIDFLI NPGDRLAQMV FVPVVQVELN IVSEFTSSQR GSGGFGHSGR 150
    Q 151
    Length:151
    Mass (Da):16,297
    Last modified:July 7, 2009 - v1
    Checksum:iD8654FAD1125E900
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001277 Genomic DNA. Translation: ACQ68855.1.
    RefSeqiWP_015874575.1. NC_012751.1.
    YP_002925003.1. NC_012751.1.

    Genome annotation databases

    EnsemblBacteriaiACQ68855; ACQ68855; HDEF_2318.
    GeneIDi7951913.
    KEGGihde:HDEF_2318.
    PATRICi31976093. VBICanHam112931_2292.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001277 Genomic DNA. Translation: ACQ68855.1 .
    RefSeqi WP_015874575.1. NC_012751.1.
    YP_002925003.1. NC_012751.1.

    3D structure databases

    ProteinModelPortali C4K8Y6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 572265.HDEF_2318.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ68855 ; ACQ68855 ; HDEF_2318 .
    GeneIDi 7951913.
    KEGGi hde:HDEF_2318.
    PATRICi 31976093. VBICanHam112931_2292.

    Phylogenomic databases

    eggNOGi COG0756.
    KOi K01520.
    OMAi SIYIGDP.
    OrthoDBi EOG689HXK.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci HDEF572265:GJAB-2340-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00116. dUTPase_bact.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
      Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
      Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 5AT.

    Entry informationi

    Entry nameiDUT_HAMD5
    AccessioniPrimary (citable) accession number: C4K8Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3