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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei386 – 3861UniRule annotation
Active sitei514 – 5141UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciHDEF572265:GJAB-49-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:HDEF_0049
OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Taxonomic identifieri572265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
ProteomesiUP000002334 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Glucose-6-phosphate isomerasePRO_1000206367Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi572265.HDEF_0049.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4K8I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKINPTQTS AWKALQQHFK EIEPIHIRHL FHADPKRSEK FSLTFNDLIR
60 70 80 90 100
VDFSKNRLTA QTIEKLQALA QETDLALAIC SMFSGGKINE TEERPVLHIA
110 120 130 140 150
LRNRGNQPIL VDGQDVMPLV NAVLEKMKRF CHQVIKGDWN GYSGQTITDV
160 170 180 190 200
VNIGIGGSDL GPYMATEALK PYKNHLKMHF VSNVDGTDIV ETLKALNPAR
210 220 230 240 250
TLFIVASKTF TTQETMTNAQ TAREWFLKTA GDSAHVARHF VALSTNIKEV
260 270 280 290 300
TNFGIDPENS FEFWDWVGGR YSLWSAIGLP IALSIGFDNF EKLLEGAYEM
310 320 330 340 350
DQHFLKTDFT HNIPVILALI GIWYSHFFGA ETEAVLPYDQ YLHRFPAYLQ
360 370 380 390 400
QASMESNGKW VDRDGKPVGY QTGSILWGEP GTNGQHAFYQ LIHQGTKIIP
410 420 430 440 450
CDFIAPVISH NAIGDHHHKL LANFFAQTQA LAFGKTEQEV QEELMAEGVF
460 470 480 490 500
SEKATYLAPF KAFSGNRPTN SILLKQITPL SLGALIALYE HKIFTQGVIL
510 520 530 540
NIFSFDQWGV ELGKKLASGI LSELEGPEKV SCHDSSTNSL INCFKKWH
Length:548
Mass (Da):61,525
Last modified:July 7, 2009 - v1
Checksum:i2C3030059A9E4F4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001277 Genomic DNA. Translation: ACQ66824.1.
RefSeqiWP_012737789.1. NC_012751.1.
YP_002922972.1. NC_012751.1.

Genome annotation databases

EnsemblBacteriaiACQ66824; ACQ66824; HDEF_0049.
KEGGihde:HDEF_0049.
PATRICi31971504. VBICanHam112931_0048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001277 Genomic DNA. Translation: ACQ66824.1.
RefSeqiWP_012737789.1. NC_012751.1.
YP_002922972.1. NC_012751.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi572265.HDEF_0049.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ66824; ACQ66824; HDEF_0049.
KEGGihde:HDEF_0049.
PATRICi31971504. VBICanHam112931_0048.

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.
BioCyciHDEF572265:GJAB-49-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
    Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
    Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5AT.

Entry informationi

Entry nameiG6PI_HAMD5
AccessioniPrimary (citable) accession number: C4K8I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: May 27, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.