C4K8I1 (DCD_HAMD5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	HDEF_0043

Organism

Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT) [Complete proteome] [HAMAP]

Taxonomic identifier

572265 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › unclassified Enterobacteriaceae › ant, tsetse, mealybug, aphid, etc. endosymbionts › aphid secondary symbionts › Candidatus Hamiltonella › Candidatus Hamiltonella defensa

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP-Rule MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP-Rule MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dUMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	dCTP deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Deoxycytidine triphosphate deaminase HAMAP-Rule MF_00146		PRO_1000203360

Sequences

	Sequence		Length	Mass (Da)
	C4K8I1 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: E6DDF4F684B36724	FASTA	193	21,739
	10 20 30 40 50 60 MRLCDHDIER WLDEKKLTIT PRPPAKHING ATVDIRLGHE FRVFVGHKAP FIDLSAPKEE 70 80 90 100 110 120 INHALDQIMS DKIVLKEKEC FFLHPGELAL AVTLESVTIP DDLVGWLDGR SSLARLGLMV 130 140 150 160 170 180 HVTAHRIDPG WRGQIVLEFY NSGKLPLGLR PGMLIGALSF ELLSGQAKRP YHQRQDAKYH 190 NQKGAVASRI DKD

References

[1]

"Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors." Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A. Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 5AT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001277 Genomic DNA. Translation: ACQ66818.1.
RefSeq	YP_002922966.1. NC_012751.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	572265.HDEF_0043.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACQ66818; ACQ66818; HDEF_0043.
GeneID	7949648.
KEGG	hde:HDEF_0043.
PATRIC	31971494. VBICanHam112931_0043.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0717.
KO	K01494.
OMA	RQDAKYK.
Enzyme and pathway databases
BioCyc	HDEF572265:GJAB-43-MONOMER.
UniPathway	UPA00610; UER00665.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase.
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. dCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_HAMD5

Accession

Primary (citable) accession number: C4K8I1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program