C4K842 (LFTR_HAMD5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferase
EC=2.3.2.6

Alternative name(s):
L/F-transferase
Leucyltransferase
Phenyalanyltransferase

Gene names

Name:	aat
Ordered Locus Names:	HDEF_0026

Organism

Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT) [Complete proteome] [HAMAP]

Taxonomic identifier

572265 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › unclassified Enterobacteriaceae › ant, tsetse, mealybug, aphid, etc. endosymbionts › aphid secondary symbionts › Candidatus Hamiltonella › Candidatus Hamiltonella defensa

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine By similarity. HAMAP-Rule MF_00688
Catalytic activity	L-leucyl-tRNA + protein = tRNA + L-leucyl-protein. HAMAP-Rule MF_00688 L-phenylalanyl-tRNA + protein = tRNA + L-phenylalanyl-protein. HAMAP-Rule MF_00688
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the L/F-transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	leucyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Leucyl/phenylalanyl-tRNA--protein transferase HAMAP-Rule MF_00688		PRO_1000212570

Sequences

	Sequence		Length	Mass (Da)
	C4K842 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: F8B4BDE0E4D2C99F	FASTA	230	25,636
	10 20 30 40 50 60 MFIKNLSKNI IDFPKPEKAL KDPNGLLASG GDLSPERLLV AYQNGIFPWF NEGEPILWWS 70 80 90 100 110 120 PDPRAVLLKC HVSRSMKRFI RPGRCPYHFS LNCAFSDVIT TCATKRSGCT WISSDIVKAY 130 140 150 160 170 180 CQLHRLGRAH SVEVWLKDKL VGGLYGISVG AMFCGESMFS IADNASKSAL IIFEHYFTQK 190 200 210 220 230 GGKWIDCQVL NAHTACLGAE QIPRNDFLSL LDQAQRVSLP KGVWSPQSLG

References

[1]

"Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors." Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A. Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 5AT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001277 Genomic DNA. Translation: ACQ66802.1.
RefSeq	YP_002922950.1. NC_012751.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	572265.HDEF_0026.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACQ66802; ACQ66802; HDEF_0026.
GeneID	7949631.
KEGG	hde:HDEF_0026.
PATRIC	31971460. VBICanHam112931_0026.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2360.
KO	K00684.
OMA	MFYGESM.
Enzyme and pathway databases
BioCyc	HDEF572265:GJAB-26-MONOMER.
Family and domain databases
HAMAP	MF_00688. Leu_Phe_trans.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR004616. Leu/Phe-tRNA_Trfase. [Graphical view]
Pfam	PF03588. Leu_Phe_trans. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMs	TIGR00667. aat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LFTR_HAMD5

Accession

Primary (citable) accession number: C4K842

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program