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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandPyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:aceFImported
Ordered Locus Names:HDEF_2043Imported
OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)Imported
Taxonomic identifieri572265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
Proteomesi
  • UP000002334 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Protein-protein interaction databases

STRINGi572265.HDEF_2043

Structurei

3D structure databases

ProteinModelPortaliC4K7S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 75Lipoyl-bindingInterPro annotationAdd BLAST74
Domaini101 – 174Lipoyl-bindingInterPro annotationAdd BLAST74
Domaini230 – 267Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QSN Bacteria
COG0508 LUCA
KOiK00627
OMAiTMEFESF
OrthoDBiPOG091H05OF

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR006256 AcTrfase_Pyrv_DH_cplx
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PANTHERiPTHR43178:SF2 PTHR43178:SF2, 3 hits
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 2 hits
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 2 hits
TIGRFAMsiTIGR01348 PDHac_trf_long, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 2 hits
PS00189 LIPOYL, 2 hits
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

C4K7S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIEIKMPDI GTDTPEVIEI MVKVGDVVVP EQTLLCVEGD KASMDIPSPQ
60 70 80 90 100
EGTIKEIKVS VGDKVETGKL IMLFESSTEA VPEKKGKTQV PAPAIPAQEN
110 120 130 140 150
TKTVSLPDVG SDELEVTEIL VKVGDSVTEE QSLITVEGDK ASMEVPAPFS
160 170 180 190 200
GTVKEIQIKT GDKVKTGSMI MIMNTIEKIT PAPDQKIQKT ADALPEQKPE
210 220 230 240 250
IPPSKPSAPS NTTTSIEKTT PSFTEEAYTH ATPVIRRLAR ELGVNLEKVA
260 270 280 290 300
GTGRKGRILK EDVQSYVKNA VQTAESASSG QGNLTPLLPW PKIDFNQFGE
310 320 330 340 350
TEEIALTRIQ KMSGDNLSRN WVMIPHVTQF DETDITDLED FRKKQNIEAE
360 370 380 390 400
KRKLDVKITP VVFMMKAVAQ ALKTFPRFNS SLSLDGKKLI LKKYINIGVA
410 420 430 440 450
VDTPNGLVVP VFRDVNKKGV IELSKELMLI SQKARSGKLT ASDMQGGCFT
460 470 480 490 500
ISSLGGIGGT AFTPIVNAPE VAILGVSKSA IKPIWNGKEF LPRLMLPLSL
510 520 530
SFDHRVIDGA AGARFVSHIS VIMADIRRLI M
Length:531
Mass (Da):57,709
Last modified:July 7, 2009 - v1
Checksum:i1094740AB48E9E03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001277 Genomic DNA Translation: ACQ68615.1
RefSeqiWP_015874368.1, NC_012751.1

Genome annotation databases

EnsemblBacteriaiACQ68615; ACQ68615; HDEF_2043
KEGGihde:HDEF_2043

Entry informationi

Entry nameiC4K7S2_HAMD5
AccessioniPrimary (citable) accession number: C4K7S2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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