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C4K7S2

- C4K7S2_HAMD5

UniProt

C4K7S2 - C4K7S2_HAMD5

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciHDEF572265:GJAB-2066-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Name:aceFImported
    Ordered Locus Names:HDEF_2043Imported
    OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)Imported
    Taxonomic identifieri572265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
    ProteomesiUP000002334: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

    Protein-protein interaction databases

    STRINGi572265.HDEF_2043.

    Structurei

    3D structure databases

    ProteinModelPortaliC4K7S2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
    Contains 2 lipoyl-binding domains.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0508.
    KOiK00627.
    OMAiTEIMVAV.
    OrthoDBiEOG610413.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 2 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 2 hits.
    TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
    PS00189. LIPOYL. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4K7S2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVIEIKMPDI GTDTPEVIEI MVKVGDVVVP EQTLLCVEGD KASMDIPSPQ    50
    EGTIKEIKVS VGDKVETGKL IMLFESSTEA VPEKKGKTQV PAPAIPAQEN 100
    TKTVSLPDVG SDELEVTEIL VKVGDSVTEE QSLITVEGDK ASMEVPAPFS 150
    GTVKEIQIKT GDKVKTGSMI MIMNTIEKIT PAPDQKIQKT ADALPEQKPE 200
    IPPSKPSAPS NTTTSIEKTT PSFTEEAYTH ATPVIRRLAR ELGVNLEKVA 250
    GTGRKGRILK EDVQSYVKNA VQTAESASSG QGNLTPLLPW PKIDFNQFGE 300
    TEEIALTRIQ KMSGDNLSRN WVMIPHVTQF DETDITDLED FRKKQNIEAE 350
    KRKLDVKITP VVFMMKAVAQ ALKTFPRFNS SLSLDGKKLI LKKYINIGVA 400
    VDTPNGLVVP VFRDVNKKGV IELSKELMLI SQKARSGKLT ASDMQGGCFT 450
    ISSLGGIGGT AFTPIVNAPE VAILGVSKSA IKPIWNGKEF LPRLMLPLSL 500
    SFDHRVIDGA AGARFVSHIS VIMADIRRLI M 531
    Length:531
    Mass (Da):57,709
    Last modified:July 7, 2009 - v1
    Checksum:i1094740AB48E9E03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001277 Genomic DNA. Translation: ACQ68615.1.
    RefSeqiWP_015874368.1. NC_012751.1.
    YP_002924763.1. NC_012751.1.

    Genome annotation databases

    EnsemblBacteriaiACQ68615; ACQ68615; HDEF_2043.
    GeneIDi7951639.
    KEGGihde:HDEF_2043.
    PATRICi31975547. VBICanHam112931_2023.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001277 Genomic DNA. Translation: ACQ68615.1 .
    RefSeqi WP_015874368.1. NC_012751.1.
    YP_002924763.1. NC_012751.1.

    3D structure databases

    ProteinModelPortali C4K7S2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 572265.HDEF_2043.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ68615 ; ACQ68615 ; HDEF_2043 .
    GeneIDi 7951639.
    KEGGi hde:HDEF_2043.
    PATRICi 31975547. VBICanHam112931_2023.

    Phylogenomic databases

    eggNOGi COG0508.
    KOi K00627.
    OMAi TEIMVAV.
    OrthoDBi EOG610413.

    Enzyme and pathway databases

    BioCyci HDEF572265:GJAB-2066-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 2 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 2 hits.
    TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 2 hits.
    PS00189. LIPOYL. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
      Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
      Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 5ATImported.

    Entry informationi

    Entry nameiC4K7S2_HAMD5
    AccessioniPrimary (citable) accession number: C4K7S2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3