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C4K7S2

- C4K7S2_HAMD5

UniProt

C4K7S2 - C4K7S2_HAMD5

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Protein
Acetyltransferase component of pyruvate dehydrogenase complex
Gene
aceF, HDEF_2043
Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.UniRule annotation
Binds 2 lipoyl cofactors covalently By similarity.UniRule annotation
Binds 3 lipoyl cofactors covalently By similarity.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciHDEF572265:GJAB-2066-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:aceFImported
Ordered Locus Names:HDEF_2043Imported
OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)Imported
Taxonomic identifieri572265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
ProteomesiUP000002334: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi572265.HDEF_2043.

Structurei

3D structure databases

ProteinModelPortaliC4K7S2.

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 2 lipoyl-binding domains.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0508.
KOiK00627.
OMAiTEIMVAV.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4K7S2-1 [UniParc]FASTAAdd to Basket

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MVIEIKMPDI GTDTPEVIEI MVKVGDVVVP EQTLLCVEGD KASMDIPSPQ    50
EGTIKEIKVS VGDKVETGKL IMLFESSTEA VPEKKGKTQV PAPAIPAQEN 100
TKTVSLPDVG SDELEVTEIL VKVGDSVTEE QSLITVEGDK ASMEVPAPFS 150
GTVKEIQIKT GDKVKTGSMI MIMNTIEKIT PAPDQKIQKT ADALPEQKPE 200
IPPSKPSAPS NTTTSIEKTT PSFTEEAYTH ATPVIRRLAR ELGVNLEKVA 250
GTGRKGRILK EDVQSYVKNA VQTAESASSG QGNLTPLLPW PKIDFNQFGE 300
TEEIALTRIQ KMSGDNLSRN WVMIPHVTQF DETDITDLED FRKKQNIEAE 350
KRKLDVKITP VVFMMKAVAQ ALKTFPRFNS SLSLDGKKLI LKKYINIGVA 400
VDTPNGLVVP VFRDVNKKGV IELSKELMLI SQKARSGKLT ASDMQGGCFT 450
ISSLGGIGGT AFTPIVNAPE VAILGVSKSA IKPIWNGKEF LPRLMLPLSL 500
SFDHRVIDGA AGARFVSHIS VIMADIRRLI M 531
Length:531
Mass (Da):57,709
Last modified:July 7, 2009 - v1
Checksum:i1094740AB48E9E03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ68615.1.
RefSeqiWP_015874368.1. NC_012751.1.
YP_002924763.1. NC_012751.1.

Genome annotation databases

EnsemblBacteriaiACQ68615; ACQ68615; HDEF_2043.
GeneIDi7951639.
KEGGihde:HDEF_2043.
PATRICi31975547. VBICanHam112931_2023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ68615.1 .
RefSeqi WP_015874368.1. NC_012751.1.
YP_002924763.1. NC_012751.1.

3D structure databases

ProteinModelPortali C4K7S2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 572265.HDEF_2043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ68615 ; ACQ68615 ; HDEF_2043 .
GeneIDi 7951639.
KEGGi hde:HDEF_2043.
PATRICi 31975547. VBICanHam112931_2023.

Phylogenomic databases

eggNOGi COG0508.
KOi K00627.
OMAi TEIMVAV.
OrthoDBi EOG610413.

Enzyme and pathway databases

BioCyci HDEF572265:GJAB-2066-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
    Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
    Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5AT.

Entry informationi

Entry nameiC4K7S2_HAMD5
AccessioniPrimary (citable) accession number: C4K7S2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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