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C4K7R7

- SYL_HAMD5

UniProt

C4K7R7 - SYL_HAMD5

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei623 – 6231ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHDEF572265:GJAB-2061-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:HDEF_2038
    OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
    Taxonomic identifieri572265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
    ProteomesiUP000002334: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 869869Leucine--tRNA ligasePRO_1000202222Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi572265.HDEF_2038.

    Structurei

    3D structure databases

    ProteinModelPortaliC4K7R7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi620 – 6245"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4K7R7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDIYRHQDI ESHVQRHWEQ TQTFTVKEDP KKEKYYCLAM WPYPSGRLHM    50
    GHVRNYTITD VIARYQRMLG KNVLQPMGWD AFGLPAEGAA IKNKTSPIDW 100
    TKANIQYMKK QLQSLGFAYD WSRELTSCKP EYYRWEQWFF TQLYEKGLVY 150
    KKTSDVNWCP QDFTVLANEQ VIDGRCWRCD SKVERKSIPQ WFIKITAYAD 200
    QLLDDLDELE HWPEQVKTMQ RHWIGRSEGV EIRFPLDHDE KTDLTVYSTR 250
    PDTLMGVAFI AIAPDHFFSA EIAKNVPALA TFIEECRHIK MAEAETATIE 300
    KKGIDTGFFA LHPLTGKKIP IWVANFVLME YGTGAVMGVP GHDQRDWEFA 350
    TQYHLPIKAV ILLEDGTEPD VQKKPLIEKG RLCHSGEFNG LSYQESCDRI 400
    IDKLVDLGTG QRKVNYRLRD WGVSRQRYWG APIPMITLED GRIIGTPEDQ 450
    LPVILPEKTL IKDMINPLKA DQDWAKTSVA GQLGIRETDT FDTFIESSWY 500
    YARYACPKYD QGMIEKAAAN YWLPVDQYVG GIEHAIMHLL YFRFFHKLMR 550
    DQGLVDSKEP AKRLLCQGMV LADAFYYNAQ NGERVWVSPT EVTVERDNKG 600
    QFLNAFDAQG RDLIHAGMSK MSKSKNNGID PQAIVEKYGA DTVRLFMMFA 650
    SAPEMTLEWQ ESGLEGAYRF LKRLWRFVFD HVIQGPTQPL KKENLNSTQK 700
    NLRRNLHKTI AKVTDDIGRR QTFNTAIAAI MELMNQLYRA PTNTEQDRAL 750
    IQEACISVIK MLYPFTPHIS FILWQHLHQS PDETHPLNID DSLWPVVDQN 800
    ALIEDETLVV IQINGKMRAK ITVPMNSTQQ EVYESALQEP TVIKHLKGIT 850
    PCHVIYVPNK LLNLVVNNE 869
    Length:869
    Mass (Da):100,422
    Last modified:July 7, 2009 - v1
    Checksum:i0A84DC84D4B2F361
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001277 Genomic DNA. Translation: ACQ68610.1.
    RefSeqiYP_002924758.1. NC_012751.1.

    Genome annotation databases

    EnsemblBacteriaiACQ68610; ACQ68610; HDEF_2038.
    GeneIDi7951634.
    KEGGihde:HDEF_2038.
    PATRICi31975537. VBICanHam112931_2018.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001277 Genomic DNA. Translation: ACQ68610.1 .
    RefSeqi YP_002924758.1. NC_012751.1.

    3D structure databases

    ProteinModelPortali C4K7R7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 572265.HDEF_2038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ68610 ; ACQ68610 ; HDEF_2038 .
    GeneIDi 7951634.
    KEGGi hde:HDEF_2038.
    PATRICi 31975537. VBICanHam112931_2018.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HDEF572265:GJAB-2061-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
      Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
      Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 5AT.

    Entry informationi

    Entry nameiSYL_HAMD5
    AccessioniPrimary (citable) accession number: C4K7R7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3