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C4K7R7

- SYL_HAMD5

UniProt

C4K7R7 - SYL_HAMD5

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Protein
Leucine--tRNA ligase
Gene
leuS, HDEF_2038
Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHDEF572265:GJAB-2061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:HDEF_2038
OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Taxonomic identifieri572265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
ProteomesiUP000002334: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Leucine--tRNA ligaseUniRule annotation
PRO_1000202222Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi572265.HDEF_2038.

Structurei

3D structure databases

ProteinModelPortaliC4K7R7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi620 – 6245"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4K7R7-1 [UniParc]FASTAAdd to Basket

« Hide

MQDIYRHQDI ESHVQRHWEQ TQTFTVKEDP KKEKYYCLAM WPYPSGRLHM    50
GHVRNYTITD VIARYQRMLG KNVLQPMGWD AFGLPAEGAA IKNKTSPIDW 100
TKANIQYMKK QLQSLGFAYD WSRELTSCKP EYYRWEQWFF TQLYEKGLVY 150
KKTSDVNWCP QDFTVLANEQ VIDGRCWRCD SKVERKSIPQ WFIKITAYAD 200
QLLDDLDELE HWPEQVKTMQ RHWIGRSEGV EIRFPLDHDE KTDLTVYSTR 250
PDTLMGVAFI AIAPDHFFSA EIAKNVPALA TFIEECRHIK MAEAETATIE 300
KKGIDTGFFA LHPLTGKKIP IWVANFVLME YGTGAVMGVP GHDQRDWEFA 350
TQYHLPIKAV ILLEDGTEPD VQKKPLIEKG RLCHSGEFNG LSYQESCDRI 400
IDKLVDLGTG QRKVNYRLRD WGVSRQRYWG APIPMITLED GRIIGTPEDQ 450
LPVILPEKTL IKDMINPLKA DQDWAKTSVA GQLGIRETDT FDTFIESSWY 500
YARYACPKYD QGMIEKAAAN YWLPVDQYVG GIEHAIMHLL YFRFFHKLMR 550
DQGLVDSKEP AKRLLCQGMV LADAFYYNAQ NGERVWVSPT EVTVERDNKG 600
QFLNAFDAQG RDLIHAGMSK MSKSKNNGID PQAIVEKYGA DTVRLFMMFA 650
SAPEMTLEWQ ESGLEGAYRF LKRLWRFVFD HVIQGPTQPL KKENLNSTQK 700
NLRRNLHKTI AKVTDDIGRR QTFNTAIAAI MELMNQLYRA PTNTEQDRAL 750
IQEACISVIK MLYPFTPHIS FILWQHLHQS PDETHPLNID DSLWPVVDQN 800
ALIEDETLVV IQINGKMRAK ITVPMNSTQQ EVYESALQEP TVIKHLKGIT 850
PCHVIYVPNK LLNLVVNNE 869
Length:869
Mass (Da):100,422
Last modified:July 7, 2009 - v1
Checksum:i0A84DC84D4B2F361
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ68610.1.
RefSeqiYP_002924758.1. NC_012751.1.

Genome annotation databases

EnsemblBacteriaiACQ68610; ACQ68610; HDEF_2038.
GeneIDi7951634.
KEGGihde:HDEF_2038.
PATRICi31975537. VBICanHam112931_2018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ68610.1 .
RefSeqi YP_002924758.1. NC_012751.1.

3D structure databases

ProteinModelPortali C4K7R7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 572265.HDEF_2038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ68610 ; ACQ68610 ; HDEF_2038 .
GeneIDi 7951634.
KEGGi hde:HDEF_2038.
PATRICi 31975537. VBICanHam112931_2018.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HDEF572265:GJAB-2061-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
    Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
    Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5AT.

Entry informationi

Entry nameiSYL_HAMD5
AccessioniPrimary (citable) accession number: C4K7R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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