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C4K7R7

- SYL_HAMD5

UniProt

C4K7R7 - SYL_HAMD5

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHDEF572265:GJAB-2061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:HDEF_2038
OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Taxonomic identifieri572265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
ProteomesiUP000002334: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Leucine--tRNA ligasePRO_1000202222Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi572265.HDEF_2038.

Structurei

3D structure databases

ProteinModelPortaliC4K7R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi620 – 6245"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4K7R7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDIYRHQDI ESHVQRHWEQ TQTFTVKEDP KKEKYYCLAM WPYPSGRLHM
60 70 80 90 100
GHVRNYTITD VIARYQRMLG KNVLQPMGWD AFGLPAEGAA IKNKTSPIDW
110 120 130 140 150
TKANIQYMKK QLQSLGFAYD WSRELTSCKP EYYRWEQWFF TQLYEKGLVY
160 170 180 190 200
KKTSDVNWCP QDFTVLANEQ VIDGRCWRCD SKVERKSIPQ WFIKITAYAD
210 220 230 240 250
QLLDDLDELE HWPEQVKTMQ RHWIGRSEGV EIRFPLDHDE KTDLTVYSTR
260 270 280 290 300
PDTLMGVAFI AIAPDHFFSA EIAKNVPALA TFIEECRHIK MAEAETATIE
310 320 330 340 350
KKGIDTGFFA LHPLTGKKIP IWVANFVLME YGTGAVMGVP GHDQRDWEFA
360 370 380 390 400
TQYHLPIKAV ILLEDGTEPD VQKKPLIEKG RLCHSGEFNG LSYQESCDRI
410 420 430 440 450
IDKLVDLGTG QRKVNYRLRD WGVSRQRYWG APIPMITLED GRIIGTPEDQ
460 470 480 490 500
LPVILPEKTL IKDMINPLKA DQDWAKTSVA GQLGIRETDT FDTFIESSWY
510 520 530 540 550
YARYACPKYD QGMIEKAAAN YWLPVDQYVG GIEHAIMHLL YFRFFHKLMR
560 570 580 590 600
DQGLVDSKEP AKRLLCQGMV LADAFYYNAQ NGERVWVSPT EVTVERDNKG
610 620 630 640 650
QFLNAFDAQG RDLIHAGMSK MSKSKNNGID PQAIVEKYGA DTVRLFMMFA
660 670 680 690 700
SAPEMTLEWQ ESGLEGAYRF LKRLWRFVFD HVIQGPTQPL KKENLNSTQK
710 720 730 740 750
NLRRNLHKTI AKVTDDIGRR QTFNTAIAAI MELMNQLYRA PTNTEQDRAL
760 770 780 790 800
IQEACISVIK MLYPFTPHIS FILWQHLHQS PDETHPLNID DSLWPVVDQN
810 820 830 840 850
ALIEDETLVV IQINGKMRAK ITVPMNSTQQ EVYESALQEP TVIKHLKGIT
860
PCHVIYVPNK LLNLVVNNE
Length:869
Mass (Da):100,422
Last modified:July 7, 2009 - v1
Checksum:i0A84DC84D4B2F361
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ68610.1.
RefSeqiYP_002924758.1. NC_012751.1.

Genome annotation databases

EnsemblBacteriaiACQ68610; ACQ68610; HDEF_2038.
GeneIDi7951634.
KEGGihde:HDEF_2038.
PATRICi31975537. VBICanHam112931_2018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ68610.1 .
RefSeqi YP_002924758.1. NC_012751.1.

3D structure databases

ProteinModelPortali C4K7R7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 572265.HDEF_2038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ68610 ; ACQ68610 ; HDEF_2038 .
GeneIDi 7951634.
KEGGi hde:HDEF_2038.
PATRICi 31975537. VBICanHam112931_2018.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HDEF572265:GJAB-2061-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
    Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
    Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5AT.

Entry informationi

Entry nameiSYL_HAMD5
AccessioniPrimary (citable) accession number: C4K7R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3