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C4K6Y1

- FMT_HAMD5

UniProt

C4K6Y1 - FMT_HAMD5

Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

    Catalytic activityi

    10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

    GO - Molecular functioni

    1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciHDEF572265:GJAB-1737-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
    Gene namesi
    Name:fmtUniRule annotation
    Ordered Locus Names:HDEF_1721
    OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
    Taxonomic identifieri572265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
    ProteomesiUP000002334: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Methionyl-tRNA formyltransferasePRO_1000203862Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi572265.HDEF_1721.

    Structurei

    3D structure databases

    ProteinModelPortaliC4K6Y1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni113 – 1164Tetrahydrofolate (THF) bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the Fmt family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0223.
    KOiK00604.
    OMAiRGDWFTP.
    OrthoDBiEOG6B09WV.

    Family and domain databases

    Gene3Di3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPiMF_00182. Formyl_trans.
    InterProiIPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view]
    PANTHERiPTHR11138. PTHR11138. 1 hit.
    PfamiPF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsiTIGR00460. fmt. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4K6Y1-1 [UniParc]FASTAAdd to Basket

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    MSESLKIIFA GTPDFSACHL QHLLSHRQKI LGVFTQPDRP AGRGKKLAFS    50
    PVKILATQHH IPVYQPHSLG LKEEQQSILD LDADVMVVVA YGLLLPQAVL 100
    NMPRLGCINV HPSLLPRWRG AAPIQRAIWA GDQETGVTIM QMDSGLDTGN 150
    MLYKTVYPIQ PDDTGASLQA KLAALGSQDL LLTLKKMAEG KMHGETQDEQ 200
    KTTYAHKLTK KEARLDWLLP AAHLERCVRA FNPWPVSYFI INEQIIKVWE 250
    AQAMPDSQQV SHLQPGTVLK ADKNGIQILT SEGVLNMTKF QLPGKKIISA 300
    WDFLNSRNEW FQIGKQLLS 319
    Length:319
    Mass (Da):35,594
    Last modified:July 7, 2009 - v1
    Checksum:i2E12DE7552ABA9CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001277 Genomic DNA. Translation: ACQ68324.1.
    RefSeqiWP_015874088.1. NC_012751.1.
    YP_002924472.1. NC_012751.1.

    Genome annotation databases

    EnsemblBacteriaiACQ68324; ACQ68324; HDEF_1721.
    GeneIDi7951318.
    KEGGihde:HDEF_1721.
    PATRICi31974901. VBICanHam112931_1711.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001277 Genomic DNA. Translation: ACQ68324.1 .
    RefSeqi WP_015874088.1. NC_012751.1.
    YP_002924472.1. NC_012751.1.

    3D structure databases

    ProteinModelPortali C4K6Y1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 572265.HDEF_1721.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ68324 ; ACQ68324 ; HDEF_1721 .
    GeneIDi 7951318.
    KEGGi hde:HDEF_1721.
    PATRICi 31974901. VBICanHam112931_1711.

    Phylogenomic databases

    eggNOGi COG0223.
    KOi K00604.
    OMAi RGDWFTP.
    OrthoDBi EOG6B09WV.

    Enzyme and pathway databases

    BioCyci HDEF572265:GJAB-1737-MONOMER.

    Family and domain databases

    Gene3Di 3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPi MF_00182. Formyl_trans.
    InterProi IPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view ]
    PANTHERi PTHR11138. PTHR11138. 1 hit.
    Pfami PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsi TIGR00460. fmt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
      Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
      Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 5AT.

    Entry informationi

    Entry nameiFMT_HAMD5
    AccessioniPrimary (citable) accession number: C4K6Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3