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C4K6F4 (SPEA_HAMD5) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:HDEF_1524
OrganismHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT) [Complete proteome] [HAMAP]
Taxonomic identifier572265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella

Protein attributes

Sequence length633 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 633633Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000215248

Regions

Region282 – 29211Substrate-binding Potential

Amino acid modifications

Modified residue1021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
C4K6F4 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: 444A0217E53529B2

FASTA63371,505
        10         20         30         40         50         60 
MNDRHAEKIR RAYNVAYWGN DYFYINDLGH ICVRPNPEVS QSSIDLAELL KEKEGKNPQP 

        70         80         90        100        110        120 
LPALFFFPQI LQHRLHAINK AFKSARDSFG YQGDYCLVYP IKVNQHRRVI ESLLKSGESL 

       130        140        150        160        170        180 
GLEAGSKAEM VAVLAYAGGT RSLIVCNGYK DREYIRLALM GEKLGYKVYL VIEKMSEIKM 

       190        200        210        220        230        240 
VLEEAKRLNV VPRLGVRARL ASEGSGKWQA SGGEKSKFGL SATQVLQLVE ILKSADCLSG 

       250        260        270        280        290        300 
LQLLHFHLGS QLSNIHDIAT GVRESARFYV ELHKLGVKIS CFDVGGGLGV DYEGTRSQSD 

       310        320        330        340        350        360 
CSVNYGLKEY ANNVIWGIGE ICNENHLPHP TVISESGRAL TAHHTVLISN VIGVERNEFS 

       370        380        390        400        410        420 
PPQAPEKHSP RALESLWYTW QEMQKPDHRH SLRECLHDSQ RDLQDVHTQY THGILDLKQR 

       430        440        450        460        470        480 
AWAEQLYLQI CHHIQKELDP SDRAHRTMID NLQERMADKL YVNFSLFQSL PDAWGINQLF 

       490        500        510        520        530        540 
PILPLEGLNQ RPERRAVLLD ITCDSDGIIE HYVDGDGVAN TLPIPPYDAE NPPILGFFMV 

       550        560        570        580        590        600 
GAYQEILGNM HNLFGDTAVV EVSLDEQEKI SVKIDNPGNT VSDMLKYVKL DPKALLAYFA 

       610        620        630 
QKIKKTDLNA QLQMAFLEEF EASLYGYTYL EHD 

« Hide

References

[1]"Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 5AT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001277 Genomic DNA. Translation: ACQ68147.1.
RefSeqYP_002924295.1. NC_012751.1.

3D structure databases

ProteinModelPortalC4K6F4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING572265.HDEF_1524.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ68147; ACQ68147; HDEF_1524.
GeneID7951124.
KEGGhde:HDEF_1524.
PATRIC31974509. VBICanHam112931_1522.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
KOK01585.
OMAIDHYVDG.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycHDEF572265:GJAB-1543-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_HAMD5
AccessionPrimary (citable) accession number: C4K6F4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways