Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C4K4T9

- C4K4T9_HAMD5

UniProt

C4K4T9 - C4K4T9_HAMD5

Protein
Submitted name:

Bifunctional penicillin-binding protein 1b: glycosyl transferase (N-terminal) transpeptidase (C-terminal)

Gene

mrcB

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei203 – 2031Proton donor; for transglycosylase activityUniRule annotation
    Active sitei481 – 4811Acyl-ester intermediate; for transpeptidase activityUniRule annotation

    GO - Molecular functioni

    1. penicillin binding Source: InterPro
    2. peptidase activity Source: InterPro
    3. peptidoglycan glycosyltransferase activity Source: InterPro

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: InterPro
    2. response to antibiotic Source: InterPro

    Keywords - Molecular functioni

    TransferaseImported

    Enzyme and pathway databases

    BioCyciHDEF572265:GJAB-868-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Bifunctional penicillin-binding protein 1b: glycosyl transferase (N-terminal) transpeptidase (C-terminal)Imported
    Gene namesi
    Name:mrcBImported
    Ordered Locus Names:HDEF_0862Imported
    OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)Imported
    Taxonomic identifieri572265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
    ProteomesiUP000002334: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-KW
    2. peptidoglycan-based cell wall Source: InterPro

    Keywords - Cellular componenti

    MembraneSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi572265.HDEF_0862.

    Structurei

    3D structure databases

    ProteinModelPortaliC4K4T9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0744.
    KOiK05365.
    OMAiPVWTDNP.
    OrthoDBiEOG6HMXCD.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR001264. Glyco_trans_51.
    IPR023346. Lysozyme-like_dom.
    IPR011813. PBP_1b.
    IPR001460. PCN-bd_Tpept.
    IPR028166. UB2H.
    [Graphical view]
    PfamiPF00912. Transgly. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    PF14814. UB2H. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002799. PBP_1b. 1 hit.
    SUPFAMiSSF53955. SSF53955. 1 hit.
    SSF56601. SSF56601. 2 hits.
    TIGRFAMsiTIGR02071. PBP_1b. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4K4T9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHYGHEPIG QKNKKIHSKL HTSIKPKHSK KKWVFLRLLF ILFLSAGLVV    50
    ILYGFYLNEK IRQRIDGQVW VLPAAVYGRM LNLEPGMAYS KKQMINLLIA 100
    TQYRKVNHLL RVGEFTVQDN SIDMLRRPFN FPDAKEDQVH ARLLFHNDRL 150
    VQIENLDNQR FFGFFRLDPR LITMLQTPSG EQRLFLPRSS FPESLVNTLL 200
    AIEDRHFYQH DGINFYSIGR ALLANILAGR TVQGGSTLTQ QLVKNLFLNN 250
    QRSFWRKANE AYMAILIDHH YSKDKILELY FNEVYLGQNG NDQIRGFPLA 300
    SLYYFGRPVD ELSLDQQAML VGMVKGASLY NPWRNPEFTL ERRNLVLKLL 350
    QNQGNIDEKL YHTLSTRPLD VQPKGGVIVP QPAFIEMVRQ ELKQKLGDKA 400
    QHLSGAKIFT TMDPVSQDAA EKAIESGIPA LKGSEHDLSD LEGAMVVIDR 450
    LSGEIRAIVG GSQPQFSGFN RALQARRSIG SLAKPAIYLS ALNQPHQYRF 500
    NTWLFDQPLS LELPNGSVWE PKNYSRKFRG QVMLLDGLVD SLNVPTVNLG 550
    MSIGLDQISQ TMKQLGAPAS TGPLMPSMLL GAINLTPLEV AQEYQTIASG 600
    GNKATLSALR SVIAADGSML YQSFPQSERK LSAQASYLVL YGMQEAVKRG 650
    TARSLSSEFS TFHLAGKTGT TNDLRDSWFA GIDGKEVTII WLGRDNNGPT 700
    QFTGSTGALT LYRRYLETKP PLPLISRKPA GIVDMNIDST TGHFICDTEP 750
    HNQISTIPVW TEDPDVLCKT SEKTTPPNEL KEKSVLDSIK NIF 793
    Length:793
    Mass (Da):89,165
    Last modified:July 7, 2009 - v1
    Checksum:iE2405417100E3143
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001277 Genomic DNA. Translation: ACQ67582.1.
    RefSeqiWP_015873397.1. NC_012751.1.
    YP_002923730.1. NC_012751.1.

    Genome annotation databases

    EnsemblBacteriaiACQ67582; ACQ67582; HDEF_0862.
    GeneIDi7950462.
    KEGGihde:HDEF_0862.
    PATRICi31973199. VBICanHam112931_0876.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001277 Genomic DNA. Translation: ACQ67582.1 .
    RefSeqi WP_015873397.1. NC_012751.1.
    YP_002923730.1. NC_012751.1.

    3D structure databases

    ProteinModelPortali C4K4T9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 572265.HDEF_0862.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ67582 ; ACQ67582 ; HDEF_0862 .
    GeneIDi 7950462.
    KEGGi hde:HDEF_0862.
    PATRICi 31973199. VBICanHam112931_0876.

    Phylogenomic databases

    eggNOGi COG0744.
    KOi K05365.
    OMAi PVWTDNP.
    OrthoDBi EOG6HMXCD.

    Enzyme and pathway databases

    BioCyci HDEF572265:GJAB-868-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR001264. Glyco_trans_51.
    IPR023346. Lysozyme-like_dom.
    IPR011813. PBP_1b.
    IPR001460. PCN-bd_Tpept.
    IPR028166. UB2H.
    [Graphical view ]
    Pfami PF00912. Transgly. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    PF14814. UB2H. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002799. PBP_1b. 1 hit.
    SUPFAMi SSF53955. SSF53955. 1 hit.
    SSF56601. SSF56601. 2 hits.
    TIGRFAMsi TIGR02071. PBP_1b. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
      Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
      Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 5ATImported.

    Entry informationi

    Entry nameiC4K4T9_HAMD5
    AccessioniPrimary (citable) accession number: C4K4T9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3