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C4K4T9

- C4K4T9_HAMD5

UniProt

C4K4T9 - C4K4T9_HAMD5

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Protein
Submitted name:

Bifunctional penicillin-binding protein 1b: glycosyl transferase (N-terminal) transpeptidase (C-terminal)

Gene

mrcB

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei203 – 2031Proton donor; for transglycosylase activityUniRule annotation
Active sitei481 – 4811Acyl-ester intermediate; for transpeptidase activityUniRule annotation

GO - Molecular functioni

  1. penicillin binding Source: InterPro
  2. peptidase activity Source: InterPro
  3. peptidoglycan glycosyltransferase activity Source: InterPro

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: InterPro
  2. response to antibiotic Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Enzyme and pathway databases

BioCyciHDEF572265:GJAB-868-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Bifunctional penicillin-binding protein 1b: glycosyl transferase (N-terminal) transpeptidase (C-terminal)Imported
Gene namesi
Name:mrcBImported
Ordered Locus Names:HDEF_0862Imported
OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)Imported
Taxonomic identifieri572265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
ProteomesiUP000002334: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
  2. peptidoglycan-based cell wall Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi572265.HDEF_0862.

Structurei

3D structure databases

ProteinModelPortaliC4K4T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0744.
KOiK05365.
OMAiPVWTDNP.
OrthoDBiEOG6HMXCD.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011813. PBP_1b.
IPR001460. PCN-bd_Tpept.
IPR028166. UB2H.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
PF14814. UB2H. 1 hit.
[Graphical view]
PIRSFiPIRSF002799. PBP_1b. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.
TIGRFAMsiTIGR02071. PBP_1b. 1 hit.

Sequencei

Sequence statusi: Complete.

C4K4T9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHYGHEPIG QKNKKIHSKL HTSIKPKHSK KKWVFLRLLF ILFLSAGLVV
60 70 80 90 100
ILYGFYLNEK IRQRIDGQVW VLPAAVYGRM LNLEPGMAYS KKQMINLLIA
110 120 130 140 150
TQYRKVNHLL RVGEFTVQDN SIDMLRRPFN FPDAKEDQVH ARLLFHNDRL
160 170 180 190 200
VQIENLDNQR FFGFFRLDPR LITMLQTPSG EQRLFLPRSS FPESLVNTLL
210 220 230 240 250
AIEDRHFYQH DGINFYSIGR ALLANILAGR TVQGGSTLTQ QLVKNLFLNN
260 270 280 290 300
QRSFWRKANE AYMAILIDHH YSKDKILELY FNEVYLGQNG NDQIRGFPLA
310 320 330 340 350
SLYYFGRPVD ELSLDQQAML VGMVKGASLY NPWRNPEFTL ERRNLVLKLL
360 370 380 390 400
QNQGNIDEKL YHTLSTRPLD VQPKGGVIVP QPAFIEMVRQ ELKQKLGDKA
410 420 430 440 450
QHLSGAKIFT TMDPVSQDAA EKAIESGIPA LKGSEHDLSD LEGAMVVIDR
460 470 480 490 500
LSGEIRAIVG GSQPQFSGFN RALQARRSIG SLAKPAIYLS ALNQPHQYRF
510 520 530 540 550
NTWLFDQPLS LELPNGSVWE PKNYSRKFRG QVMLLDGLVD SLNVPTVNLG
560 570 580 590 600
MSIGLDQISQ TMKQLGAPAS TGPLMPSMLL GAINLTPLEV AQEYQTIASG
610 620 630 640 650
GNKATLSALR SVIAADGSML YQSFPQSERK LSAQASYLVL YGMQEAVKRG
660 670 680 690 700
TARSLSSEFS TFHLAGKTGT TNDLRDSWFA GIDGKEVTII WLGRDNNGPT
710 720 730 740 750
QFTGSTGALT LYRRYLETKP PLPLISRKPA GIVDMNIDST TGHFICDTEP
760 770 780 790
HNQISTIPVW TEDPDVLCKT SEKTTPPNEL KEKSVLDSIK NIF
Length:793
Mass (Da):89,165
Last modified:July 7, 2009 - v1
Checksum:iE2405417100E3143
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ67582.1.
RefSeqiWP_015873397.1. NC_012751.1.
YP_002923730.1. NC_012751.1.

Genome annotation databases

EnsemblBacteriaiACQ67582; ACQ67582; HDEF_0862.
GeneIDi7950462.
KEGGihde:HDEF_0862.
PATRICi31973199. VBICanHam112931_0876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ67582.1 .
RefSeqi WP_015873397.1. NC_012751.1.
YP_002923730.1. NC_012751.1.

3D structure databases

ProteinModelPortali C4K4T9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 572265.HDEF_0862.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ67582 ; ACQ67582 ; HDEF_0862 .
GeneIDi 7950462.
KEGGi hde:HDEF_0862.
PATRICi 31973199. VBICanHam112931_0876.

Phylogenomic databases

eggNOGi COG0744.
KOi K05365.
OMAi PVWTDNP.
OrthoDBi EOG6HMXCD.

Enzyme and pathway databases

BioCyci HDEF572265:GJAB-868-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011813. PBP_1b.
IPR001460. PCN-bd_Tpept.
IPR028166. UB2H.
[Graphical view ]
Pfami PF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
PF14814. UB2H. 1 hit.
[Graphical view ]
PIRSFi PIRSF002799. PBP_1b. 1 hit.
SUPFAMi SSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.
TIGRFAMsi TIGR02071. PBP_1b. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
    Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
    Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5ATImported.

Entry informationi

Entry nameiC4K4T9_HAMD5
AccessioniPrimary (citable) accession number: C4K4T9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3