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C4K4T9

- C4K4T9_HAMD5

UniProt

C4K4T9 - C4K4T9_HAMD5

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Protein
Submitted name: Bifunctional penicillin-binding protein 1b: glycosyl transferase (N-terminal) transpeptidase (C-terminal)
Gene
mrcB, HDEF_0862
Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei203 – 2031Proton donor; for transglycosylase activity By similarityUniRule annotation
Active sitei481 – 4811Acyl-ester intermediate; for transpeptidase activity By similarityUniRule annotation

GO - Molecular functioni

  1. penicillin binding Source: InterPro
  2. peptidase activity Source: InterPro
  3. peptidoglycan glycosyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: InterPro
  2. response to antibiotic Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Enzyme and pathway databases

BioCyciHDEF572265:GJAB-868-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Bifunctional penicillin-binding protein 1b: glycosyl transferase (N-terminal) transpeptidase (C-terminal)Imported
Gene namesi
Name:mrcBImported
Ordered Locus Names:HDEF_0862Imported
OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)Imported
Taxonomic identifieri572265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
ProteomesiUP000002334: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
  2. peptidoglycan-based cell wall Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi572265.HDEF_0862.

Structurei

3D structure databases

ProteinModelPortaliC4K4T9.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0744.
KOiK05365.
OMAiPVWTDNP.
OrthoDBiEOG6HMXCD.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011813. PBP_1b.
IPR001460. PCN-bd_Tpept.
IPR028166. UB2H.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
PF14814. UB2H. 1 hit.
[Graphical view]
PIRSFiPIRSF002799. PBP_1b. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.
TIGRFAMsiTIGR02071. PBP_1b. 1 hit.

Sequencei

Sequence statusi: Complete.

C4K4T9-1 [UniParc]FASTAAdd to Basket

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MSHYGHEPIG QKNKKIHSKL HTSIKPKHSK KKWVFLRLLF ILFLSAGLVV    50
ILYGFYLNEK IRQRIDGQVW VLPAAVYGRM LNLEPGMAYS KKQMINLLIA 100
TQYRKVNHLL RVGEFTVQDN SIDMLRRPFN FPDAKEDQVH ARLLFHNDRL 150
VQIENLDNQR FFGFFRLDPR LITMLQTPSG EQRLFLPRSS FPESLVNTLL 200
AIEDRHFYQH DGINFYSIGR ALLANILAGR TVQGGSTLTQ QLVKNLFLNN 250
QRSFWRKANE AYMAILIDHH YSKDKILELY FNEVYLGQNG NDQIRGFPLA 300
SLYYFGRPVD ELSLDQQAML VGMVKGASLY NPWRNPEFTL ERRNLVLKLL 350
QNQGNIDEKL YHTLSTRPLD VQPKGGVIVP QPAFIEMVRQ ELKQKLGDKA 400
QHLSGAKIFT TMDPVSQDAA EKAIESGIPA LKGSEHDLSD LEGAMVVIDR 450
LSGEIRAIVG GSQPQFSGFN RALQARRSIG SLAKPAIYLS ALNQPHQYRF 500
NTWLFDQPLS LELPNGSVWE PKNYSRKFRG QVMLLDGLVD SLNVPTVNLG 550
MSIGLDQISQ TMKQLGAPAS TGPLMPSMLL GAINLTPLEV AQEYQTIASG 600
GNKATLSALR SVIAADGSML YQSFPQSERK LSAQASYLVL YGMQEAVKRG 650
TARSLSSEFS TFHLAGKTGT TNDLRDSWFA GIDGKEVTII WLGRDNNGPT 700
QFTGSTGALT LYRRYLETKP PLPLISRKPA GIVDMNIDST TGHFICDTEP 750
HNQISTIPVW TEDPDVLCKT SEKTTPPNEL KEKSVLDSIK NIF 793
Length:793
Mass (Da):89,165
Last modified:July 7, 2009 - v1
Checksum:iE2405417100E3143
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ67582.1.
RefSeqiWP_015873397.1. NC_012751.1.
YP_002923730.1. NC_012751.1.

Genome annotation databases

EnsemblBacteriaiACQ67582; ACQ67582; HDEF_0862.
GeneIDi7950462.
KEGGihde:HDEF_0862.
PATRICi31973199. VBICanHam112931_0876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ67582.1 .
RefSeqi WP_015873397.1. NC_012751.1.
YP_002923730.1. NC_012751.1.

3D structure databases

ProteinModelPortali C4K4T9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 572265.HDEF_0862.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ67582 ; ACQ67582 ; HDEF_0862 .
GeneIDi 7950462.
KEGGi hde:HDEF_0862.
PATRICi 31973199. VBICanHam112931_0876.

Phylogenomic databases

eggNOGi COG0744.
KOi K05365.
OMAi PVWTDNP.
OrthoDBi EOG6HMXCD.

Enzyme and pathway databases

BioCyci HDEF572265:GJAB-868-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011813. PBP_1b.
IPR001460. PCN-bd_Tpept.
IPR028166. UB2H.
[Graphical view ]
Pfami PF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
PF14814. UB2H. 1 hit.
[Graphical view ]
PIRSFi PIRSF002799. PBP_1b. 1 hit.
SUPFAMi SSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.
TIGRFAMsi TIGR02071. PBP_1b. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
    Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
    Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5AT.

Entry informationi

Entry nameiC4K4T9_HAMD5
AccessioniPrimary (citable) accession number: C4K4T9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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