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C4K4D1

- PUR5_HAMD5

UniProt

C4K4D1 - PUR5_HAMD5

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, HDEF_0691
Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHDEF572265:GJAB-696-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:HDEF_0691
OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Taxonomic identifieri572265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
ProteomesiUP000002334: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000212825Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi572265.HDEF_0691.

Structurei

3D structure databases

ProteinModelPortaliC4K4D1.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

C4K4D1-1 [UniParc]FASTAAdd to Basket

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MTDHVSLNYK DAGVDIHAGY LLVERIKKAV KQTHRPEVIG GLGGFGALCA    50
LPQKYREPIL VSGTDGVGTK LRLAIDLKRH ETIGIDLVAM CVNDLIVQGA 100
EPLFFLDYFA TGQLDVETAA CVIAGIAEGC QQAGCALVGG ETAEMPGMYQ 150
AKDYDLAGFC LGVVEKSKLI NGHQNVKSGD TLLALASSGL HSNGYSLVRQ 200
VLNLSKKDPE TWMLNGKSLA DHLLEPTRIY VKSILTLIET QNVDIHAIAH 250
LTGGGFFENI PRVLPKNTCV LIEESSWQWP CIFDWLQKTG NINKQEMYRT 300
FNCGVGMIIA LPENQADKTL DFLTSVGEKA WRIGRVDSSK TSSERIIFKK 350
SILNN 355
Length:355
Mass (Da):38,808
Last modified:July 7, 2009 - v1
Checksum:i0BC7DBCA1672969C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ67424.1.
RefSeqiWP_015873245.1. NC_012751.1.
YP_002923572.1. NC_012751.1.

Genome annotation databases

EnsemblBacteriaiACQ67424; ACQ67424; HDEF_0691.
GeneIDi7950294.
KEGGihde:HDEF_0691.
PATRICi31972835. VBICanHam112931_0699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ67424.1 .
RefSeqi WP_015873245.1. NC_012751.1.
YP_002923572.1. NC_012751.1.

3D structure databases

ProteinModelPortali C4K4D1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 572265.HDEF_0691.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ67424 ; ACQ67424 ; HDEF_0691 .
GeneIDi 7950294.
KEGGi hde:HDEF_0691.
PATRICi 31972835. VBICanHam112931_0699.

Phylogenomic databases

eggNOGi COG0150.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci HDEF572265:GJAB-696-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
    Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
    Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5AT.

Entry informationi

Entry nameiPUR5_HAMD5
AccessioniPrimary (citable) accession number: C4K4D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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