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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:HDEF_0691
OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Taxonomic identifieri572265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
Proteomesi
  • UP000002334 Componenti: Chromosome

Subcellular locationi

C4K4D1:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002128251 – 355Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST355

Interactioni

Protein-protein interaction databases

STRINGi572265.HDEF_0691.

Structurei

3D structure databases

ProteinModelPortaliC4K4D1.
SMRiC4K4D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB. Bacteria.
COG0150. LUCA.
KOiK01933.
OMAiNHCVNDI.
OrthoDBiPOG091H0128.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiView protein in InterPro
IPR010918. PurM-like_C_dom.
IPR036676. PurM-like_C_sf.
IPR016188. PurM-like_N.
IPR036921. PurM-like_N_sf.
IPR004733. PurM_cligase.
PANTHERiPTHR10520. PTHR10520. 1 hit.
PfamiView protein in Pfam
PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

C4K4D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDHVSLNYK DAGVDIHAGY LLVERIKKAV KQTHRPEVIG GLGGFGALCA
60 70 80 90 100
LPQKYREPIL VSGTDGVGTK LRLAIDLKRH ETIGIDLVAM CVNDLIVQGA
110 120 130 140 150
EPLFFLDYFA TGQLDVETAA CVIAGIAEGC QQAGCALVGG ETAEMPGMYQ
160 170 180 190 200
AKDYDLAGFC LGVVEKSKLI NGHQNVKSGD TLLALASSGL HSNGYSLVRQ
210 220 230 240 250
VLNLSKKDPE TWMLNGKSLA DHLLEPTRIY VKSILTLIET QNVDIHAIAH
260 270 280 290 300
LTGGGFFENI PRVLPKNTCV LIEESSWQWP CIFDWLQKTG NINKQEMYRT
310 320 330 340 350
FNCGVGMIIA LPENQADKTL DFLTSVGEKA WRIGRVDSSK TSSERIIFKK

SILNN
Length:355
Mass (Da):38,808
Last modified:July 7, 2009 - v1
Checksum:i0BC7DBCA1672969C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001277 Genomic DNA. Translation: ACQ67424.1.
RefSeqiWP_015873245.1. NC_012751.1.

Genome annotation databases

EnsemblBacteriaiACQ67424; ACQ67424; HDEF_0691.
KEGGihde:HDEF_0691.

Similar proteinsi

Entry informationi

Entry nameiPUR5_HAMD5
AccessioniPrimary (citable) accession number: C4K4D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: October 25, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families