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C4K4D1 (PUR5_HAMD5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:HDEF_0691
OrganismHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT) [Complete proteome] [HAMAP]
Taxonomic identifier572265 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › aphid secondary symbionts › Candidatus Hamiltonella ›

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00741.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741
PRO_1000212825

Sequences

Sequence LengthMass (Da)Tools
C4K4D1 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: 0BC7DBCA1672969C

FASTA35538,808
        10         20         30         40         50         60 
MTDHVSLNYK DAGVDIHAGY LLVERIKKAV KQTHRPEVIG GLGGFGALCA LPQKYREPIL 

        70         80         90        100        110        120 
VSGTDGVGTK LRLAIDLKRH ETIGIDLVAM CVNDLIVQGA EPLFFLDYFA TGQLDVETAA 

       130        140        150        160        170        180 
CVIAGIAEGC QQAGCALVGG ETAEMPGMYQ AKDYDLAGFC LGVVEKSKLI NGHQNVKSGD 

       190        200        210        220        230        240 
TLLALASSGL HSNGYSLVRQ VLNLSKKDPE TWMLNGKSLA DHLLEPTRIY VKSILTLIET 

       250        260        270        280        290        300 
QNVDIHAIAH LTGGGFFENI PRVLPKNTCV LIEESSWQWP CIFDWLQKTG NINKQEMYRT 

       310        320        330        340        350 
FNCGVGMIIA LPENQADKTL DFLTSVGEKA WRIGRVDSSK TSSERIIFKK SILNN

« Hide

References

[1]"Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 5AT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001277 Genomic DNA. Translation: ACQ67424.1.
RefSeqYP_002923572.1. NC_012751.1.

3D structure databases

ProteinModelPortalC4K4D1.
ModBaseSearch...

Protein-protein interaction databases

STRING572265.HDEF_0691.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ67424; ACQ67424; HDEF_0691.
GeneID7950294.
KEGGhde:HDEF_0691.
PATRIC31972835. VBICanHam112931_0699.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0150.
KOK01933.
OMAPRVLPKH.

Enzyme and pathway databases

BioCycHDEF572265:GJAB-696-MONOMER.
UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.90.650.10. 1 hit.
HAMAPMF_00741_B. AIRS_B.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 1 hit.
SSF55326. PurM_N-like. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_HAMD5
AccessionPrimary (citable) accession number: C4K4D1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: May 29, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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