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C4K4C4

- ALR_HAMD5

UniProt

C4K4C4 - ALR_HAMD5

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Protein

Alanine racemase

Gene

alr

Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Active sitei254 – 2541Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei302 – 3021Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHDEF572265:GJAB-684-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:HDEF_0679
OrganismiHamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Taxonomic identifieri572265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeaphid secondary symbiontsCandidatus Hamiltonella
ProteomesiUP000002334: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Alanine racemasePRO_1000213835Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi572265.HDEF_0679.

Structurei

3D structure databases

ProteinModelPortaliC4K4C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
KOiK01775.
OMAiLWQLEAI.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4K4C4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGATAIINL KSLRHNLEKI QQYAPKSRLM AVVKANAYGH GLLTVAQALK
60 70 80 90 100
NADYFSVARI EEALTLRSGG IIKPILLLEG FFSLEDLAVL QVNHIETVIH
110 120 130 140 150
NFEQLVALEK VRLPEPVRVW MKIDTGMHRL GVRLEQADAF YQRLQNCPNV
160 170 180 190 200
AKPIHIITHL SDVNPHHPVV TDQQIRSFDA FVQGKPGQKS IAASGAILLC
210 220 230 240 250
PQSHRDVVRP GIALYGISPF EHFIGRDYGL LPVMTLQSPL IAVREHKAGE
260 270 280 290 300
TVGYAGEWIS QTATFLGVLA IGYGDGYPQS APTGTPVWIN DRQVPIVGRV
310 320 330 340 350
SMDMISVDLG RDATDKVGDR AVLWGDQLSL EKVASYIGYT AYELVSKLTG

RVAISYVN
Length:358
Mass (Da):39,378
Last modified:July 7, 2009 - v1
Checksum:i00ED6051FA0C5F9A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ67417.1.
RefSeqiYP_002923565.1. NC_012751.1.

Genome annotation databases

EnsemblBacteriaiACQ67417; ACQ67417; HDEF_0679.
GeneIDi7950282.
KEGGihde:HDEF_0679.
PATRICi31972809. VBICanHam112931_0691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001277 Genomic DNA. Translation: ACQ67417.1 .
RefSeqi YP_002923565.1. NC_012751.1.

3D structure databases

ProteinModelPortali C4K4C4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 572265.HDEF_0679.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ67417 ; ACQ67417 ; HDEF_0679 .
GeneIDi 7950282.
KEGGi hde:HDEF_0679.
PATRICi 31972809. VBICanHam112931_0691.

Phylogenomic databases

eggNOGi COG0787.
KOi K01775.
OMAi LWQLEAI.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HDEF572265:GJAB-684-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors."
    Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.
    Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5AT.

Entry informationi

Entry nameiALR_HAMD5
AccessioniPrimary (citable) accession number: C4K4C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3