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C4K1Z7 (ISCS_RICPU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cysteine desulfurase
EC=2.8.1.7
Gene names
Name:iscS
Ordered Locus Names:RPR_04680
OrganismRickettsia peacockii (strain Rustic) [Complete proteome] [HAMAP]
Taxonomic identifier562019 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group ›

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the removal of elemental sulfur from cysteine to produce alanine By similarity. HAMAP-Rule MF_00331

Catalytic activity

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor. HAMAP-Rule MF_00331

Cofactor

Pyridoxal phosphate By similarity.

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcysteine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncysteine desulfurase activity

Inferred from electronic annotation. Source: HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Cysteine desulfurase HAMAP-Rule MF_00331
PRO_1000205174

Sites

Active site3341Cysteine persulfide intermediate By similarity

Amino acid modifications

Modified residue2111N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
C4K1Z7 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: 270AB52556C2FED3

FASTA41045,417
        10         20         30         40         50         60 
MNPQLNNLTL PIYMDYQATT PIDPRVMEAM LPYFTTKFGN PHSRSHSFGW EAENAVEEAR 

        70         80         90        100        110        120 
SMVAKLIGAD TKEIIFTSGA TESNNLAIKG IAKFYSNKKN HIITVVSEHK CVLDACRHLE 

       130        140        150        160        170        180 
QEGIKITYLP IKPNGIIDLE TLKNAITDQT MLVSVMVVNN EIGVVQPLKE IGKICREKGV 

       190        200        210        220        230        240 
FFHSDIAQGF GKIPIDVNAF NIDLASISGH KIYGPKGIGA LYVRKKPRVR VTPLINGGGQ 

       250        260        270        280        290        300 
ERGMRSGTLP TPLIVGLGMA AEIAYSEMEK DTKHVNYLFD RFLNNIHKRI SEVYLNGDKN 

       310        320        330        340        350        360 
QRYKGNLNLS FAGVEGESMI LAIKDLAVSS GSACTSASLE PSYVLRSMGI GEELAHTAIR 

       370        380        390        400        410 
FGIGRFTTEQ EVDYAVNLIC SKIDKLRALS PLWEMMQEGI DLKKIKWAVH

« Hide

References

[1]"Genome sequence of the endosymbiont Rickettsia peacockii and comparison with virulent Rickettsia rickettsii: identification of virulence factors."
Felsheim R.F., Kurtti T.J., Munderloh U.G.
PLoS ONE 4:E8361-E8361(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rustic.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001227 Genomic DNA. Translation: ACR47595.1.
RefSeqYP_002916646.1. NC_012730.1.

3D structure databases

ProteinModelPortalC4K1Z7.
ModBaseSearch...

Protein-protein interaction databases

STRING562019.RPR_04680.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR47595; ACR47595; RPR_04680.
GeneID7942761.
KEGGrpk:RPR_04680.
PATRIC17899429. VBIRicPea48268_0925.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1104.
HOGENOMHOG000017510.
KOK04487.
OMAKPRIRLQ.
ProtClustDBPRK14012.

Enzyme and pathway databases

BioCycRPEA562019:GJD7-606-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_00331. Cys_desulf_aminotr_5.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR010240. Cys_deSase.
IPR016454. Cysteine_dSase_NifS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF005572. NifS. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR02006. IscS. 1 hit.
PROSITEPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISCS_RICPU
AccessionPrimary (citable) accession number: C4K1Z7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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