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C4K126 (DDL_RICPU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:RPR_02150
OrganismRickettsia peacockii (strain Rustic) [Complete proteome] [HAMAP]
Taxonomic identifier562019 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000202205

Regions

Domain121 – 317197ATP-grasp
Nucleotide binding147 – 19953ATP By similarity

Sites

Metal binding2701Magnesium or manganese 1 By similarity
Metal binding2841Magnesium or manganese 1 By similarity
Metal binding2841Magnesium or manganese 2 By similarity
Metal binding2861Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
C4K126 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: 63073B54290378D7

FASTA32336,116
        10         20         30         40         50         60 
MHKYQTHWVE HSIVKILSST GKKHIALMAG GMSAEREVSL VSSEGVSKAL IELGYRVTFI 

        70         80         90        100        110        120 
DMGADIAVRL QEIKPDIVFN CLHGTYGEDG CLPGLLNIMR IPYTHSGVLS SALAFNKIHS 

       130        140        150        160        170        180 
RIWFLTNNIN MAESIVVNKS DNIKNDPMKR PYVIKPLAQG SSIGVEVIFA EDDFNFADYD 

       190        200        210        220        230        240 
FPYGDQVIIE QYIKGQGREL QVAVLNGKAL GALEIKLLKN RFYDYETKYT EGFADHLCPA 

       250        260        270        280        290        300 
PLPANLYEKL LIESEKIYKT MNCKGPARAE FILEEQTNKL YALEINTHPG MMPLSIVPEI 

       310        320 
AAYAGINFTN LIEEIIKTAS FES 

« Hide

References

[1]"Genome sequence of the endosymbiont Rickettsia peacockii and comparison with virulent Rickettsia rickettsii: identification of virulence factors."
Felsheim R.F., Kurtti T.J., Munderloh U.G.
PLoS ONE 4:E8361-E8361(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rustic.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001227 Genomic DNA. Translation: ACR47277.1.
RefSeqYP_002916325.1. NC_012730.1.

3D structure databases

ProteinModelPortalC4K126.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING562019.RPR_02150.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR47277; ACR47277; RPR_02150.
GeneID7942678.
KEGGrpk:RPR_02150.
PATRIC17898394. VBIRicPea48268_0422.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAYVGCDIP.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycRPEA562019:GJD7-272-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_RICPU
AccessionPrimary (citable) accession number: C4K126
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways