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Protein

Hydroxymethylglutaryl-CoA synthase

Gene

UREG_07400

Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.UniRule annotation

Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxymethylglutaryl-CoA synthase (UREG_07400)
  3. 3-hydroxy-3-methylglutaryl coenzyme A reductase (UREG_01707)
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesisUniRule annotation, Sterol metabolism

Enzyme and pathway databases

UniPathwayiUPA00058; UER00102.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylglutaryl-CoA synthaseUniRule annotation (EC:2.3.3.10UniRule annotation)
Short name:
HMG-CoA synthaseUniRule annotation
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthaseUniRule annotation
Gene namesi
ORF Names:UREG_07400Imported
OrganismiUncinocarpus reesii (strain UAMH 1704)Imported
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
Proteomesi
  • UP000002058 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi336963.XP_002582627.1.

Structurei

3D structure databases

ProteinModelPortaliC4JYZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 177HMG_CoA_synt_NInterPro annotationAdd BLAST174
Domaini179 – 428HMG_CoA_synt_CInterPro annotationAdd BLAST250

Sequence similaritiesi

Belongs to the HMG-CoA synthase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1393. Eukaryota.
COG3425. LUCA.
InParanoidiC4JYZ9.
KOiK01641.
OrthoDBiEOG092C22BG.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
PfamiView protein in Pfam
PF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
SUPFAMiSSF53901. SSF53901. 3 hits.
TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEiView protein in PROSITE
PS01226. HMG_COA_SYNTHASE. 1 hit.

Sequencei

Sequence statusi: Complete.

C4JYZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRPQNIGI KALEVYFPSQ CVDQAELEKF DGVSQGKYTI GLGQTKMSFC
60 70 80 90 100
DDREDIYSMA LTTLSSLLRK YNIDPTSIGR LEVGTETILD KSKSVKSVLM
110 120 130 140 150
QLFAPAGNTN VEGVDTVNAC YGGTNALFNS INWVESSAWD GRDAIVVTGD
160 170 180 190 200
IALYKKGNAR PTGGAGCVAM LIGPNAPMVI ESGLRGSYIT HAYDFYKPDL
210 220 230 240 250
TSEYPYVDGH FSIKCYTQAV DACYKAYNAR EKALSPAQNG EISTDESKTP
260 270 280 290 300
LDRFDHILFH APTCKLVSKS YGRLLYNDYL ANPSHPAFAE VPAEILDLDY
310 320 330 340 350
DKSLSDKTVE KTFMALTKKR FAEKVQPSIQ VATLCGNMYC ASVYGGLVSL
360 370 380 390 400
LSNVAFDATK PKRVGVFSYG SGLASSMFSL KIVGDVSNIV EKLDLQKRLD
410 420 430 440
ARRVVSPQVF DDMCLLREKA HLKKDFTSYW QPRGPIPRNL LPYQSR
Length:446
Mass (Da):49,183
Last modified:July 7, 2009 - v1
Checksum:i1239C517FB52DC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476619 Genomic DNA. Translation: EEP82535.1.
RefSeqiXP_002582627.1. XM_002582581.1.

Genome annotation databases

EnsemblFungiiEEP82535; EEP82535; UREG_07400.
GeneIDi8440001.
KEGGiure:UREG_07400.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiC4JYZ9_UNCRE
AccessioniPrimary (citable) accession number: C4JYZ9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: July 5, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported