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Protein

Signal peptidase complex catalytic subunit SEC11

Gene

SEC11

Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS26.010

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11 (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I
Gene namesi
Name:SEC11
ORF Names:UREG_07275
OrganismiUncinocarpus reesii (strain UAMH 1704)
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
Proteomesi
  • UP000002058 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UREG_07275

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 33HelicalSequence analysisAdd BLAST19
Topological domaini34 – 166LumenalSequence analysisAdd BLAST133
Transmembranei167 – 185HelicalSequence analysisAdd BLAST19
Topological domaini186 – 210CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004123701 – 210Signal peptidase complex catalytic subunit SEC11Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Component of the signal peptidase complex (SPC).By similarity

Protein-protein interaction databases

STRINGi336963.XP_002582502.1

Structurei

3D structure databases

SMRiC4JYM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342 Eukaryota
COG0681 LUCA
InParanoidiC4JYM4
KOiK13280
OrthoDBiEOG092C4ZUJ

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
PANTHERiPTHR10806 PTHR10806, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit

Sequencei

Sequence statusi: Complete.

C4JYM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSLSPHLS NVRQTLTQVL NFALVLSTAF MMWKALSIYT NSSSPIVVVL
60 70 80 90 100
SGSMEPAFQR GDLLFLWNRS PRAEVGEIVV YNVRGKDIPI VHRVVRAFGD
110 120 130 140 150
DARDPKEGGG KKGKSASGTG KKESVAAGAV HSDSSFVSHK LLTKGDNNIA
160 170 180 190 200
DDTELYARGQ DYLDRKVDLV GSVRGYIPAV GYVTIMLSEH PWLKSVLLGL
210
MGVMVILQRE
Length:210
Mass (Da):22,889
Last modified:July 7, 2009 - v1
Checksum:iB7B8E2E76D4C22BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476619 Genomic DNA Translation: EEP82410.1
RefSeqiXP_002582502.1, XM_002582456.1

Genome annotation databases

EnsemblFungiiEEP82410; EEP82410; UREG_07275
GeneIDi8438820
KEGGiure:UREG_07275

Similar proteinsi

Entry informationi

Entry nameiSEC11_UNCRE
AccessioniPrimary (citable) accession number: C4JYM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: July 7, 2009
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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