Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal peptidase complex catalytic subunit SEC11

Gene

SEC11

Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11 (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I
Gene namesi
Name:SEC11
ORF Names:UREG_07275
OrganismiUncinocarpus reesii (strain UAMH 1704)
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
Proteomesi
  • UP000002058 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 33HelicalSequence analysisAdd BLAST19
Topological domaini34 – 166LumenalSequence analysisAdd BLAST133
Transmembranei167 – 185HelicalSequence analysisAdd BLAST19
Topological domaini186 – 210CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004123701 – 210Signal peptidase complex catalytic subunit SEC11Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Component of the signal peptidase complex (SPC).By similarity

Protein-protein interaction databases

STRINGi336963.XP_002582502.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
InParanoidiC4JYM4.
KOiK13280.
OrthoDBiEOG092C4ZUJ.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 2 hits.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4JYM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSLSPHLS NVRQTLTQVL NFALVLSTAF MMWKALSIYT NSSSPIVVVL
60 70 80 90 100
SGSMEPAFQR GDLLFLWNRS PRAEVGEIVV YNVRGKDIPI VHRVVRAFGD
110 120 130 140 150
DARDPKEGGG KKGKSASGTG KKESVAAGAV HSDSSFVSHK LLTKGDNNIA
160 170 180 190 200
DDTELYARGQ DYLDRKVDLV GSVRGYIPAV GYVTIMLSEH PWLKSVLLGL
210
MGVMVILQRE
Length:210
Mass (Da):22,889
Last modified:July 7, 2009 - v1
Checksum:iB7B8E2E76D4C22BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476619 Genomic DNA. Translation: EEP82410.1.
RefSeqiXP_002582502.1. XM_002582456.1.

Genome annotation databases

EnsemblFungiiEEP82410; EEP82410; UREG_07275.
GeneIDi8438820.
KEGGiure:UREG_07275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476619 Genomic DNA. Translation: EEP82410.1.
RefSeqiXP_002582502.1. XM_002582456.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi336963.XP_002582502.1.

Protein family/group databases

MEROPSiS26.010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEP82410; EEP82410; UREG_07275.
GeneIDi8438820.
KEGGiure:UREG_07275.

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
InParanoidiC4JYM4.
KOiK13280.
OrthoDBiEOG092C4ZUJ.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 2 hits.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC11_UNCRE
AccessioniPrimary (citable) accession number: C4JYM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.