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C4JTD3

- KEX1_UNCRE

UniProt

C4JTD3 - KEX1_UNCRE

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei184 – 1841By similarity
    Active sitei386 – 3861By similarity
    Active sitei448 – 4481By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:UREG_05722
    OrganismiUncinocarpus reesii (strain UAMH 1704)
    Taxonomic identifieri336963 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
    ProteomesiUP000002058: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 638606Pheromone-processing carboxypeptidase KEX1PRO_0000411949Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiC4JTD3.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 519487LumenalSequence AnalysisAdd
    BLAST
    Topological domaini541 – 63898CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei520 – 54021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C4JTD3-1 [UniParc]FASTAAdd to Basket

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    MSSCQPPPFL SSMVVRWLSV WIILASSAFA SAKCAADYYV RSLPGQPEGP    50
    LLKMHAGHIE VDHENNGNLF FWHFQNRHIA NRQRTVIWLN GGPGCSSMDG 100
    AMMEVGPYRL KDDHTLKYNE GSWDEFANLL FVDQPVGTGY SYANTNSYLH 150
    ELDEMAAHFV TFMERWFELF PEYEHDDLYF AGESYAGQYI PYIAKAILDR 200
    NKNETVIAQR RLWHLKGLLI GNGWFSPVEQ YLSYLPYVYK EGMVKNDSDE 250
    AKGIERAHSD CVAELDRAKG DVKIHVDVCE KILSAILDVS NKSGHCVNMY 300
    DVRLTDTFPS CGMNWPPDLK HLAPYLRRDD VTSALHINKD KKTGWTECAG 350
    AVSSSFRPRK SKPSADLLPG LLESGVRIGL FSGAKDLICN HIGTEEFINK 400
    MEWSGGKGFE LSPGVWAPRR DWTFEGETAG YYQEARNLTY VLFYNASHMV 450
    PFDYARRSRD MLDRFLGVDI TSIGGNPTDS RIDGEKGALT SVGNHPNSTL 500
    AEQREKEKLK AATWKAYYKS GEVALVVVVI AAGAWGFFLW RSRRQRQGSG 550
    YLGIYPSLNG LSSGSLPRYR NKRSSRDIEA AAEFEASELE TLHDMDDRSP 600
    GPSRDNYSVG EDSETEDEKR YPPTDFDRQD GTPSASRT 638
    Length:638
    Mass (Da):71,903
    Last modified:July 7, 2009 - v1
    Checksum:iE9974ECF7A5C0FF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476617 Genomic DNA. Translation: EEP80880.1.
    RefSeqiXP_002585033.1. XM_002584987.1.

    Genome annotation databases

    GeneIDi8439360.
    KEGGiure:UREG_05722.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476617 Genomic DNA. Translation: EEP80880.1 .
    RefSeqi XP_002585033.1. XM_002584987.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Proteomic databases

    PRIDEi C4JTD3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8439360.
    KEGGi ure:UREG_05722.

    Phylogenomic databases

    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UAMH 1704.

    Entry informationi

    Entry nameiKEX1_UNCRE
    AccessioniPrimary (citable) accession number: C4JTD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3