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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei184 – 1841By similarity
Active sitei386 – 3861By similarity
Active sitei448 – 4481By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:UREG_05722
OrganismiUncinocarpus reesii (strain UAMH 1704)
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
ProteomesiUP000002058 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 519487LumenalSequence AnalysisAdd
BLAST
Transmembranei520 – 54021HelicalSequence AnalysisAdd
BLAST
Topological domaini541 – 63898CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 638606Pheromone-processing carboxypeptidase KEX1PRO_0000411949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiC4JTD3.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiC4JTD3.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4JTD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSCQPPPFL SSMVVRWLSV WIILASSAFA SAKCAADYYV RSLPGQPEGP
60 70 80 90 100
LLKMHAGHIE VDHENNGNLF FWHFQNRHIA NRQRTVIWLN GGPGCSSMDG
110 120 130 140 150
AMMEVGPYRL KDDHTLKYNE GSWDEFANLL FVDQPVGTGY SYANTNSYLH
160 170 180 190 200
ELDEMAAHFV TFMERWFELF PEYEHDDLYF AGESYAGQYI PYIAKAILDR
210 220 230 240 250
NKNETVIAQR RLWHLKGLLI GNGWFSPVEQ YLSYLPYVYK EGMVKNDSDE
260 270 280 290 300
AKGIERAHSD CVAELDRAKG DVKIHVDVCE KILSAILDVS NKSGHCVNMY
310 320 330 340 350
DVRLTDTFPS CGMNWPPDLK HLAPYLRRDD VTSALHINKD KKTGWTECAG
360 370 380 390 400
AVSSSFRPRK SKPSADLLPG LLESGVRIGL FSGAKDLICN HIGTEEFINK
410 420 430 440 450
MEWSGGKGFE LSPGVWAPRR DWTFEGETAG YYQEARNLTY VLFYNASHMV
460 470 480 490 500
PFDYARRSRD MLDRFLGVDI TSIGGNPTDS RIDGEKGALT SVGNHPNSTL
510 520 530 540 550
AEQREKEKLK AATWKAYYKS GEVALVVVVI AAGAWGFFLW RSRRQRQGSG
560 570 580 590 600
YLGIYPSLNG LSSGSLPRYR NKRSSRDIEA AAEFEASELE TLHDMDDRSP
610 620 630
GPSRDNYSVG EDSETEDEKR YPPTDFDRQD GTPSASRT
Length:638
Mass (Da):71,903
Last modified:July 7, 2009 - v1
Checksum:iE9974ECF7A5C0FF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476617 Genomic DNA. Translation: EEP80880.1.
RefSeqiXP_002585033.1. XM_002584987.1.

Genome annotation databases

GeneIDi8439360.
KEGGiure:UREG_05722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476617 Genomic DNA. Translation: EEP80880.1.
RefSeqiXP_002585033.1. XM_002584987.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.007.

Proteomic databases

PRIDEiC4JTD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8439360.
KEGGiure:UREG_05722.

Phylogenomic databases

InParanoidiC4JTD3.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UAMH 1704.

Entry informationi

Entry nameiKEX1_UNCRE
AccessioniPrimary (citable) accession number: C4JTD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 7, 2009
Last modified: January 7, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.