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C4JSX6

- MAP2_UNCRE

UniProt

C4JSX6 - MAP2_UNCRE

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Protein

Methionine aminopeptidase 2

Gene
UREG_05565
Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei200 – 2001Substrate By similarity
Metal bindingi220 – 2201Divalent metal cation 1 By similarity
Metal bindingi231 – 2311Divalent metal cation 1 By similarity
Metal bindingi231 – 2311Divalent metal cation 2; catalytic By similarity
Metal bindingi300 – 3001Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei308 – 3081Substrate By similarity
Metal bindingi336 – 3361Divalent metal cation 2; catalytic By similarity
Metal bindingi431 – 4311Divalent metal cation 1 By similarity
Metal bindingi431 – 4311Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2 (EC:3.4.11.18)
Short name:
MAP 2
Short name:
MetAP 2
Alternative name(s):
Peptidase M
Gene namesi
ORF Names:UREG_05565
OrganismiUncinocarpus reesii (strain UAMH 1704)
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
ProteomesiUP000002058: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Methionine aminopeptidase 2UniRule annotationPRO_0000407671Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC4JSX6.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 7718Lys-richUniRule annotationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

KOiK01265.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4JSX6-1 [UniParc]FASTAAdd to Basket

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MAVQAPEVDK LSLNEESVAK APTKGSAAQG TAGDEDAENE ESDEDDDQGV    50
AEGAVATGDK KKRKRKPKKK KKKGVAKVQS NPPRVPLSTL FPNSQYPEGD 100
IVEYKDDNAY RTTNEEKRHL DRMNNDFLSD YRQAAEIHRQ VRQYAQKELI 150
KPGRSLTEIA EGIEDSVRAL TGHMGLEEGD SLVAGMGFPT GLNINHCAAH 200
YSPNAGNKMV LQHGDVMKVD FGVHVNGRIV DSAFTVAFDP VYDNLLEAVK 250
DATNTGIREA GIDVRMSDIG AAIQEAMESY EVELNGTTYP VKAIRNLNGH 300
TIGHYLIHGG STGKSVPIVK GGDQTKMEEG ETYAIETFGS TGKGYVRDDM 350
EVSHYARVPD APNVPLRLSS AKNLLNVITK NFGTLPFCRR YLDRLGQDKY 400
LLGLNNLVSS GLVDAYPPLV DVKGSYTAQF EHTILLRPNV KEVITRGDDY 450
Length:450
Mass (Da):49,283
Last modified:July 7, 2009 - v1
Checksum:iDDF2D150E0E36A3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476617 Genomic DNA. Translation: EEP80723.1.
RefSeqiXP_002584876.1. XM_002584830.1.

Genome annotation databases

GeneIDi8441071.
KEGGiure:UREG_05565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476617 Genomic DNA. Translation: EEP80723.1 .
RefSeqi XP_002584876.1. XM_002584830.1.

3D structure databases

ProteinModelPortali C4JSX6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8441071.
KEGGi ure:UREG_05565.

Phylogenomic databases

KOi K01265.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UAMH 1704.

Entry informationi

Entry nameiMAP2_UNCRE
AccessioniPrimary (citable) accession number: C4JSX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 7, 2009
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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