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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei264 – 2641PROSITE-ProRule annotation
Active sitei455 – 4551PROSITE-ProRule annotation
Active sitei517 – 5171PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:UREG_03020
OrganismiUncinocarpus reesii (strain UAMH 1704)
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
ProteomesiUP000002058 Componenti: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 122105By similarityPRO_0000407490Add
BLAST
Chaini123 – 541419Carboxypeptidase Y homolog APRO_0000407491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi177 ↔ 416By similarity
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi311 ↔ 325By similarity
Disulfide bondi335 ↔ 358By similarity
Disulfide bondi342 ↔ 351By similarity
Disulfide bondi380 ↔ 386By similarity
Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiC4JNM2.
KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4JNM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFTAALLV GTALAAVPQQ QPLQTQVEDS AWAKPLEDLK DTIKSMGAEA
60 70 80 90 100
KQAWDQLASA FPDALNEYTL FSAPKKHTRR PDSHWDHVVR GADVQGIWVD
110 120 130 140 150
GVDGQKHREV DGKLENYDLR VKAVDPSKLG IDPGVKQFSG YLDDNENDKH
160 170 180 190 200
LFYWFFESRN DPKNDPVVLW LNGGPGCSSL TGLFFELGPA SIDKNLKVIH
210 220 230 240 250
NPYSWNSNAS VIFLDQPVNV GFSYSGSSVS DTIAAGKDVY ALLTLFFKQF
260 270 280 290 300
PQYAKQDFHI AGESYAGHYI PAFASEILSH KNRNINLKSV LIGNGLTDPL
310 320 330 340 350
TQYPHYRPMA CGEGGYPAVL DESSCRSMDN ALPRCQSMIE SCYSSESAWV
360 370 380 390 400
CVPASIYCNN AMIGPYQRTG QNVYDVRTKC EDGSLCYTGL NYITQWLNQK
410 420 430 440 450
PVMEALGAEV ESYDSCNMDI NRNFLFHGDW MKPYHRLVPG LIEKLPVLIY
460 470 480 490 500
AGDADFICNW LGNKAWTETL EWSGRAEFAS AEMKNLTIVD NKSKGKNIGQ
510 520 530 540
VKSHGNFTFM RLFGGGHMVP LDQPEASLEF FNRWLGGEWK A
Length:541
Mass (Da):60,405
Last modified:July 6, 2009 - v1
Checksum:i67D2CE6C1BB51FB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476616 Genomic DNA. Translation: EEP78175.1.
RefSeqiXP_002543504.1. XM_002543458.1.

Genome annotation databases

GeneIDi8439365.
KEGGiure:UREG_03020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476616 Genomic DNA. Translation: EEP78175.1.
RefSeqiXP_002543504.1. XM_002543458.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8439365.
KEGGiure:UREG_03020.

Phylogenomic databases

InParanoidiC4JNM2.
KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UAMH 1704.

Entry informationi

Entry nameiCBPYA_UNCRE
AccessioniPrimary (citable) accession number: C4JNM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2011
Last sequence update: July 6, 2009
Last modified: January 6, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.