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C4JNM2

- CBPYA_UNCRE

UniProt

C4JNM2 - CBPYA_UNCRE

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Protein
Carboxypeptidase Y homolog A
Gene
cpyA, UREG_03020
Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei264 – 2641 By similarity
Active sitei455 – 4551 By similarity
Active sitei517 – 5171 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:UREG_03020
OrganismiUncinocarpus reesii (strain UAMH 1704)
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
ProteomesiUP000002058: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Propeptidei18 – 122105 By similarity
PRO_0000407490Add
BLAST
Chaini123 – 541419Carboxypeptidase Y homolog A
PRO_0000407491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi177 ↔ 416 By similarity
Glycosylationi208 – 2081N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi311 ↔ 325 By similarity
Disulfide bondi335 ↔ 358 By similarity
Disulfide bondi342 ↔ 351 By similarity
Disulfide bondi380 ↔ 386 By similarity
Glycosylationi485 – 4851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi491 – 4911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi506 – 5061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4JNM2-1 [UniParc]FASTAAdd to Basket

« Hide

MKTFTAALLV GTALAAVPQQ QPLQTQVEDS AWAKPLEDLK DTIKSMGAEA    50
KQAWDQLASA FPDALNEYTL FSAPKKHTRR PDSHWDHVVR GADVQGIWVD 100
GVDGQKHREV DGKLENYDLR VKAVDPSKLG IDPGVKQFSG YLDDNENDKH 150
LFYWFFESRN DPKNDPVVLW LNGGPGCSSL TGLFFELGPA SIDKNLKVIH 200
NPYSWNSNAS VIFLDQPVNV GFSYSGSSVS DTIAAGKDVY ALLTLFFKQF 250
PQYAKQDFHI AGESYAGHYI PAFASEILSH KNRNINLKSV LIGNGLTDPL 300
TQYPHYRPMA CGEGGYPAVL DESSCRSMDN ALPRCQSMIE SCYSSESAWV 350
CVPASIYCNN AMIGPYQRTG QNVYDVRTKC EDGSLCYTGL NYITQWLNQK 400
PVMEALGAEV ESYDSCNMDI NRNFLFHGDW MKPYHRLVPG LIEKLPVLIY 450
AGDADFICNW LGNKAWTETL EWSGRAEFAS AEMKNLTIVD NKSKGKNIGQ 500
VKSHGNFTFM RLFGGGHMVP LDQPEASLEF FNRWLGGEWK A 541
Length:541
Mass (Da):60,405
Last modified:July 7, 2009 - v1
Checksum:i67D2CE6C1BB51FB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476616 Genomic DNA. Translation: EEP78175.1.
RefSeqiXP_002543504.1. XM_002543458.1.

Genome annotation databases

GeneIDi8439365.
KEGGiure:UREG_03020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476616 Genomic DNA. Translation: EEP78175.1 .
RefSeqi XP_002543504.1. XM_002543458.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8439365.
KEGGi ure:UREG_03020.

Phylogenomic databases

KOi K13289.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UAMH 1704.

Entry informationi

Entry nameiCBPYA_UNCRE
AccessioniPrimary (citable) accession number: C4JNM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 7, 2009
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi