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C4JNM2

- CBPYA_UNCRE

UniProt

C4JNM2 - CBPYA_UNCRE

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei264 – 2641PROSITE-ProRule annotation
    Active sitei455 – 4551PROSITE-ProRule annotation
    Active sitei517 – 5171PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:UREG_03020
    OrganismiUncinocarpus reesii (strain UAMH 1704)
    Taxonomic identifieri336963 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
    ProteomesiUP000002058: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 122105By similarityPRO_0000407490Add
    BLAST
    Chaini123 – 541419Carboxypeptidase Y homolog APRO_0000407491Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi177 ↔ 416By similarity
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi311 ↔ 325By similarity
    Disulfide bondi335 ↔ 358By similarity
    Disulfide bondi342 ↔ 351By similarity
    Disulfide bondi380 ↔ 386By similarity
    Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK13289.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C4JNM2-1 [UniParc]FASTAAdd to Basket

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    MKTFTAALLV GTALAAVPQQ QPLQTQVEDS AWAKPLEDLK DTIKSMGAEA    50
    KQAWDQLASA FPDALNEYTL FSAPKKHTRR PDSHWDHVVR GADVQGIWVD 100
    GVDGQKHREV DGKLENYDLR VKAVDPSKLG IDPGVKQFSG YLDDNENDKH 150
    LFYWFFESRN DPKNDPVVLW LNGGPGCSSL TGLFFELGPA SIDKNLKVIH 200
    NPYSWNSNAS VIFLDQPVNV GFSYSGSSVS DTIAAGKDVY ALLTLFFKQF 250
    PQYAKQDFHI AGESYAGHYI PAFASEILSH KNRNINLKSV LIGNGLTDPL 300
    TQYPHYRPMA CGEGGYPAVL DESSCRSMDN ALPRCQSMIE SCYSSESAWV 350
    CVPASIYCNN AMIGPYQRTG QNVYDVRTKC EDGSLCYTGL NYITQWLNQK 400
    PVMEALGAEV ESYDSCNMDI NRNFLFHGDW MKPYHRLVPG LIEKLPVLIY 450
    AGDADFICNW LGNKAWTETL EWSGRAEFAS AEMKNLTIVD NKSKGKNIGQ 500
    VKSHGNFTFM RLFGGGHMVP LDQPEASLEF FNRWLGGEWK A 541
    Length:541
    Mass (Da):60,405
    Last modified:July 7, 2009 - v1
    Checksum:i67D2CE6C1BB51FB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476616 Genomic DNA. Translation: EEP78175.1.
    RefSeqiXP_002543504.1. XM_002543458.1.

    Genome annotation databases

    GeneIDi8439365.
    KEGGiure:UREG_03020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476616 Genomic DNA. Translation: EEP78175.1 .
    RefSeqi XP_002543504.1. XM_002543458.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8439365.
    KEGGi ure:UREG_03020.

    Phylogenomic databases

    KOi K13289.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UAMH 1704.

    Entry informationi

    Entry nameiCBPYA_UNCRE
    AccessioniPrimary (citable) accession number: C4JNM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3