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C4JHY5

- DAPB_UNCRE

UniProt

C4JHY5 - DAPB_UNCRE

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei751 – 7511Charge relay systemBy similarity
    Active sitei828 – 8281Charge relay systemBy similarity
    Active sitei861 – 8611Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:UREG_01410
    OrganismiUncinocarpus reesii (strain UAMH 1704)
    Taxonomic identifieri336963 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
    ProteomesiUP000002058: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 914914Probable dipeptidyl-aminopeptidase BPRO_0000412167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi810 – 8101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi897 – 8971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliC4JHY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8888CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini110 – 914805VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei89 – 10921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01282.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4JHY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAEKRINDE EAQPLTGRDR SRDSIDSTST ASISLALIDQ ANRSTHAGRT    50
    TPPRNFGNGE KYRDNDDDNP EGGLPPPSGA QRTPKKVSII FWLVAALCVG 100
    GWLVAFFVFM GSPKKDSDKE VVVSGAENST VPGVVSTGGK KVDLDGVLTG 150
    FWSPRSHEIS WIPGPDGEDG LLLEQDGDEN AGYLRVENIR NQKSTNKKDD 200
    AVVLMKRETF KVGARRVRPS KVWPSPDLKT VLVMSDRLKN WRHSYTGNYW 250
    LFNVETQTGE PLDPGSPDGR IQLASWSPKS DSVVFTRDNN MFIRNLSSKD 300
    VKPITTDGGV NLFYGIPDWV YEEEVFSGNS ATWWDNDGKF VAFLRTNESR 350
    VPEYPVQYFI PTVGRVAHAG EEHYPNTRKI KYPKAGAPNP TVNIQFFDVE 400
    KGEVFSIEME DDLPDHDRLI IEVIWASNGK VLVRETNRES DRLSMVLVDA 450
    KDRTAKVIRS QDFSKLDGGW IEPSQSTYFI PADPGNGRPH DGYIETVPFE 500
    GFNHLAYFTP LDNPSPVFLT SGNWEVTDAP SAVDLKRGLV YFVAAKEQPT 550
    ERHVYTVRLD GSDLQPIVNT KAPAYYTISL STGAGYALLK YEGPEIPWQK 600
    VISTPANEER FEETIENNTE LAGRAKDYAL PSLYYQTITI DGYTLPVVER 650
    RPPNFNPDKK YPVLFHLYGG PGSQTVSKRF KVDFQSYVAS NLGYIVVTVD 700
    GRGTGFIGRK ARCVVRDNLG HYEAIDQIET AKAWGKRPYV DATRMAIWGW 750
    SYGGFMTLKT LERDAGQTFQ YGMAVAPVTD WQFYDSIYTE RYMHTPQNNP 800
    AGYANTAVSN VTALGQTVRF MVIHGTGDDN VHYQNTLTLL DKLDVDNVGN 850
    FDVHVYPDSD HGIYFHNAYK MLHERLSDWL VNAFNGEWVK IRNPVPNKSL 900
    MRRARSLLKR MSNA 914
    Length:914
    Mass (Da):102,559
    Last modified:July 7, 2009 - v1
    Checksum:i454062230C415045
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476615 Genomic DNA. Translation: EEP76561.1.
    RefSeqiXP_002541894.1. XM_002541848.1.

    Genome annotation databases

    GeneIDi8440664.
    KEGGiure:UREG_01410.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476615 Genomic DNA. Translation: EEP76561.1 .
    RefSeqi XP_002541894.1. XM_002541848.1.

    3D structure databases

    ProteinModelPortali C4JHY5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8440664.
    KEGGi ure:UREG_01410.

    Phylogenomic databases

    KOi K01282.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UAMH 1704.

    Entry informationi

    Entry nameiDAPB_UNCRE
    AccessioniPrimary (citable) accession number: C4JHY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3