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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei751Charge relay systemBy similarity1
Active sitei828Charge relay systemBy similarity1
Active sitei861Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERiuncre-dapb. DPP4N_Peptidase_S9.
MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:UREG_01410
OrganismiUncinocarpus reesii (strain UAMH 1704)
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
Proteomesi
  • UP000002058 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 88CytoplasmicSequence analysisAdd BLAST88
Transmembranei89 – 109Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini110 – 914VacuolarSequence analysisAdd BLAST805

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121671 – 914Probable dipeptidyl-aminopeptidase BAdd BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi617N-linked (GlcNAc...)Sequence analysis1
Glycosylationi810N-linked (GlcNAc...)Sequence analysis1
Glycosylationi897N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi336963.XP_002541894.1.

Structurei

3D structure databases

ProteinModelPortaliC4JHY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
InParanoidiC4JHY5.
KOiK01282.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

C4JHY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAEKRINDE EAQPLTGRDR SRDSIDSTST ASISLALIDQ ANRSTHAGRT
60 70 80 90 100
TPPRNFGNGE KYRDNDDDNP EGGLPPPSGA QRTPKKVSII FWLVAALCVG
110 120 130 140 150
GWLVAFFVFM GSPKKDSDKE VVVSGAENST VPGVVSTGGK KVDLDGVLTG
160 170 180 190 200
FWSPRSHEIS WIPGPDGEDG LLLEQDGDEN AGYLRVENIR NQKSTNKKDD
210 220 230 240 250
AVVLMKRETF KVGARRVRPS KVWPSPDLKT VLVMSDRLKN WRHSYTGNYW
260 270 280 290 300
LFNVETQTGE PLDPGSPDGR IQLASWSPKS DSVVFTRDNN MFIRNLSSKD
310 320 330 340 350
VKPITTDGGV NLFYGIPDWV YEEEVFSGNS ATWWDNDGKF VAFLRTNESR
360 370 380 390 400
VPEYPVQYFI PTVGRVAHAG EEHYPNTRKI KYPKAGAPNP TVNIQFFDVE
410 420 430 440 450
KGEVFSIEME DDLPDHDRLI IEVIWASNGK VLVRETNRES DRLSMVLVDA
460 470 480 490 500
KDRTAKVIRS QDFSKLDGGW IEPSQSTYFI PADPGNGRPH DGYIETVPFE
510 520 530 540 550
GFNHLAYFTP LDNPSPVFLT SGNWEVTDAP SAVDLKRGLV YFVAAKEQPT
560 570 580 590 600
ERHVYTVRLD GSDLQPIVNT KAPAYYTISL STGAGYALLK YEGPEIPWQK
610 620 630 640 650
VISTPANEER FEETIENNTE LAGRAKDYAL PSLYYQTITI DGYTLPVVER
660 670 680 690 700
RPPNFNPDKK YPVLFHLYGG PGSQTVSKRF KVDFQSYVAS NLGYIVVTVD
710 720 730 740 750
GRGTGFIGRK ARCVVRDNLG HYEAIDQIET AKAWGKRPYV DATRMAIWGW
760 770 780 790 800
SYGGFMTLKT LERDAGQTFQ YGMAVAPVTD WQFYDSIYTE RYMHTPQNNP
810 820 830 840 850
AGYANTAVSN VTALGQTVRF MVIHGTGDDN VHYQNTLTLL DKLDVDNVGN
860 870 880 890 900
FDVHVYPDSD HGIYFHNAYK MLHERLSDWL VNAFNGEWVK IRNPVPNKSL
910
MRRARSLLKR MSNA
Length:914
Mass (Da):102,559
Last modified:July 7, 2009 - v1
Checksum:i454062230C415045
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476615 Genomic DNA. Translation: EEP76561.1.
RefSeqiXP_002541894.1. XM_002541848.1.

Genome annotation databases

EnsemblFungiiEEP76561; EEP76561; UREG_01410.
GeneIDi8440664.
KEGGiure:UREG_01410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476615 Genomic DNA. Translation: EEP76561.1.
RefSeqiXP_002541894.1. XM_002541848.1.

3D structure databases

ProteinModelPortaliC4JHY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi336963.XP_002541894.1.

Protein family/group databases

ESTHERiuncre-dapb. DPP4N_Peptidase_S9.
MEROPSiS09.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEP76561; EEP76561; UREG_01410.
GeneIDi8440664.
KEGGiure:UREG_01410.

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
InParanoidiC4JHY5.
KOiK01282.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDAPB_UNCRE
AccessioniPrimary (citable) accession number: C4JHY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 7, 2009
Last modified: September 7, 2016
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.