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C4JHY5

- DAPB_UNCRE

UniProt

C4JHY5 - DAPB_UNCRE

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
DAPB, UREG_01410
Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei751 – 7511Charge relay system By similarity
Active sitei828 – 8281Charge relay system By similarity
Active sitei861 – 8611Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:UREG_01410
OrganismiUncinocarpus reesii (strain UAMH 1704)
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
ProteomesiUP000002058: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8888Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei89 – 10921Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini110 – 914805Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 914914Probable dipeptidyl-aminopeptidase BPRO_0000412167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi128 – 1281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi295 – 2951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi617 – 6171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi810 – 8101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi897 – 8971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC4JHY5.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

C4JHY5-1 [UniParc]FASTAAdd to Basket

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MGAEKRINDE EAQPLTGRDR SRDSIDSTST ASISLALIDQ ANRSTHAGRT    50
TPPRNFGNGE KYRDNDDDNP EGGLPPPSGA QRTPKKVSII FWLVAALCVG 100
GWLVAFFVFM GSPKKDSDKE VVVSGAENST VPGVVSTGGK KVDLDGVLTG 150
FWSPRSHEIS WIPGPDGEDG LLLEQDGDEN AGYLRVENIR NQKSTNKKDD 200
AVVLMKRETF KVGARRVRPS KVWPSPDLKT VLVMSDRLKN WRHSYTGNYW 250
LFNVETQTGE PLDPGSPDGR IQLASWSPKS DSVVFTRDNN MFIRNLSSKD 300
VKPITTDGGV NLFYGIPDWV YEEEVFSGNS ATWWDNDGKF VAFLRTNESR 350
VPEYPVQYFI PTVGRVAHAG EEHYPNTRKI KYPKAGAPNP TVNIQFFDVE 400
KGEVFSIEME DDLPDHDRLI IEVIWASNGK VLVRETNRES DRLSMVLVDA 450
KDRTAKVIRS QDFSKLDGGW IEPSQSTYFI PADPGNGRPH DGYIETVPFE 500
GFNHLAYFTP LDNPSPVFLT SGNWEVTDAP SAVDLKRGLV YFVAAKEQPT 550
ERHVYTVRLD GSDLQPIVNT KAPAYYTISL STGAGYALLK YEGPEIPWQK 600
VISTPANEER FEETIENNTE LAGRAKDYAL PSLYYQTITI DGYTLPVVER 650
RPPNFNPDKK YPVLFHLYGG PGSQTVSKRF KVDFQSYVAS NLGYIVVTVD 700
GRGTGFIGRK ARCVVRDNLG HYEAIDQIET AKAWGKRPYV DATRMAIWGW 750
SYGGFMTLKT LERDAGQTFQ YGMAVAPVTD WQFYDSIYTE RYMHTPQNNP 800
AGYANTAVSN VTALGQTVRF MVIHGTGDDN VHYQNTLTLL DKLDVDNVGN 850
FDVHVYPDSD HGIYFHNAYK MLHERLSDWL VNAFNGEWVK IRNPVPNKSL 900
MRRARSLLKR MSNA 914
Length:914
Mass (Da):102,559
Last modified:July 7, 2009 - v1
Checksum:i454062230C415045
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476615 Genomic DNA. Translation: EEP76561.1.
RefSeqiXP_002541894.1. XM_002541848.1.

Genome annotation databases

GeneIDi8440664.
KEGGiure:UREG_01410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476615 Genomic DNA. Translation: EEP76561.1 .
RefSeqi XP_002541894.1. XM_002541848.1.

3D structure databases

ProteinModelPortali C4JHY5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8440664.
KEGGi ure:UREG_01410.

Phylogenomic databases

KOi K01282.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UAMH 1704.

Entry informationi

Entry nameiDAPB_UNCRE
AccessioniPrimary (citable) accession number: C4JHY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 7, 2009
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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