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C4JHY5 (DAPB_UNCRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:UREG_01410
OrganismUncinocarpus reesii (strain UAMH 1704) [Complete proteome]
Taxonomic identifier336963 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus

Protein attributes

Sequence length914 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentMembrane
Vacuole
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 914914Probable dipeptidyl-aminopeptidase B
PRO_0000412167

Regions

Topological domain1 – 8888Cytoplasmic Potential
Transmembrane89 – 10921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain110 – 914805Vacuolar Potential

Sites

Active site7511Charge relay system By similarity
Active site8281Charge relay system By similarity
Active site8611Charge relay system By similarity

Amino acid modifications

Glycosylation1281N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation6171N-linked (GlcNAc...) Potential
Glycosylation8101N-linked (GlcNAc...) Potential
Glycosylation8971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C4JHY5 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: 454062230C415045

FASTA914102,559
        10         20         30         40         50         60 
MGAEKRINDE EAQPLTGRDR SRDSIDSTST ASISLALIDQ ANRSTHAGRT TPPRNFGNGE 

        70         80         90        100        110        120 
KYRDNDDDNP EGGLPPPSGA QRTPKKVSII FWLVAALCVG GWLVAFFVFM GSPKKDSDKE 

       130        140        150        160        170        180 
VVVSGAENST VPGVVSTGGK KVDLDGVLTG FWSPRSHEIS WIPGPDGEDG LLLEQDGDEN 

       190        200        210        220        230        240 
AGYLRVENIR NQKSTNKKDD AVVLMKRETF KVGARRVRPS KVWPSPDLKT VLVMSDRLKN 

       250        260        270        280        290        300 
WRHSYTGNYW LFNVETQTGE PLDPGSPDGR IQLASWSPKS DSVVFTRDNN MFIRNLSSKD 

       310        320        330        340        350        360 
VKPITTDGGV NLFYGIPDWV YEEEVFSGNS ATWWDNDGKF VAFLRTNESR VPEYPVQYFI 

       370        380        390        400        410        420 
PTVGRVAHAG EEHYPNTRKI KYPKAGAPNP TVNIQFFDVE KGEVFSIEME DDLPDHDRLI 

       430        440        450        460        470        480 
IEVIWASNGK VLVRETNRES DRLSMVLVDA KDRTAKVIRS QDFSKLDGGW IEPSQSTYFI 

       490        500        510        520        530        540 
PADPGNGRPH DGYIETVPFE GFNHLAYFTP LDNPSPVFLT SGNWEVTDAP SAVDLKRGLV 

       550        560        570        580        590        600 
YFVAAKEQPT ERHVYTVRLD GSDLQPIVNT KAPAYYTISL STGAGYALLK YEGPEIPWQK 

       610        620        630        640        650        660 
VISTPANEER FEETIENNTE LAGRAKDYAL PSLYYQTITI DGYTLPVVER RPPNFNPDKK 

       670        680        690        700        710        720 
YPVLFHLYGG PGSQTVSKRF KVDFQSYVAS NLGYIVVTVD GRGTGFIGRK ARCVVRDNLG 

       730        740        750        760        770        780 
HYEAIDQIET AKAWGKRPYV DATRMAIWGW SYGGFMTLKT LERDAGQTFQ YGMAVAPVTD 

       790        800        810        820        830        840 
WQFYDSIYTE RYMHTPQNNP AGYANTAVSN VTALGQTVRF MVIHGTGDDN VHYQNTLTLL 

       850        860        870        880        890        900 
DKLDVDNVGN FDVHVYPDSD HGIYFHNAYK MLHERLSDWL VNAFNGEWVK IRNPVPNKSL 

       910 
MRRARSLLKR MSNA 

« Hide

References

[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UAMH 1704.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476615 Genomic DNA. Translation: EEP76561.1.
RefSeqXP_002541894.1. XM_002541848.1.

3D structure databases

ProteinModelPortalC4JHY5.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8440664.
KEGGure:UREG_01410.

Phylogenomic databases

KOK01282.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_UNCRE
AccessionPrimary (citable) accession number: C4JHY5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 7, 2009
Last modified: April 16, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries