C4JF09 (AMPP3_UNCRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase PEPP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	PEPP
ORF Names:	UREG_00910

Organism

Uncinocarpus reesii (strain UAMH 1704) [Complete proteome]

Taxonomic identifier

336963 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Onygenaceae › Uncinocarpus › Uncinocarpus reesii

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	Probable Xaa-Pro aminopeptidase PEPP		PRO_0000411891
Sites
	Metal binding	265	1	Manganese 2 By similarity
	Metal binding	276	1	Manganese 1 By similarity
	Metal binding	276	1	Manganese 2 By similarity
	Metal binding	399	1	Manganese 1 By similarity
	Metal binding	439	1	Manganese 1 By similarity
	Metal binding	439	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C4JF09 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: 910865F9CF96DF77	FASTA	481	53,659
	10 20 30 40 50 60 MDPAVDKILA GKYPAKQHAR RVAEALKAAG QDGSGVIYLE GTKTRMAEDS DEAVPFRQRR 70 80 90 100 110 120 NFYYLSGCDL SDSYVTYNID KDELVLYIPP ADPDEVIWTG LPMSAEEALK VYDVDVVLPS 130 140 150 160 170 180 TEVNAQLAHC CANKDSKPKR VYAIPDRVCP ETTFLPFDDT NWDVLAQAIE QCRKVKDEYE 190 200 210 220 230 240 IALLKRANEI SAQAHLAVMK ASKTAKNERE LEAIFRSTCL YYDSRQQSYG PIMARGVNGA 250 260 270 280 290 300 TLHYQTNNMD IDDPVTGERP SLLIDAGGEY RMYASDITRA IPLSGKFSPE ARQIYDIVLD 310 320 330 340 350 360 MQMQCFGMIK AGVAWDDVHA LAHKVAIKGL VNLGILRGSE EELFQKGVSV AFFPHGLGHY 370 380 390 400 410 420 MGMDTHDVGG NPNFADPNPM FKYLRLRGTL SPNEVVTVEP GVYFCRFIIE PYLKSPELSK 430 440 450 460 470 480 YIDSAVLDKY WKVGGVRIED NLVVTQDGFQ NLTTVPKDAE EVERIVQQGV PAFVLVSIND I

References

[1]

"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UAMH 1704.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476615 Genomic DNA. Translation: EEP76062.1.
RefSeq	XP_002541395.1. XM_002541349.1.
3D structure databases
ProteinModelPortal	C4JF09.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8437708.
KEGG	ure:UREG_00910.
Phylogenomic databases
KO	K14213.
OrthoDB	EOG4J40RD.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_UNCRE

Accession

Primary (citable) accession number: C4JF09

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 7, 2009
Last modified:	March 6, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program