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C4JE77

- LIPA_UNCRE

UniProt

C4JE77 - LIPA_UNCRE

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Protein
Lipoyl synthase, mitochondrial
Gene
UREG_00501
Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi134 – 1341Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi139 – 1391Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi145 – 1451Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi165 – 1651Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi169 – 1691Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi172 – 1721Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, mitochondrial (EC:2.8.1.8)
Alternative name(s):
Lipoate synthase
Short name:
LS
Short name:
Lip-syn
Lipoic acid synthase
Gene namesi
ORF Names:UREG_00501
OrganismiUncinocarpus reesii (strain UAMH 1704)
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
ProteomesiUP000002058: Unassembled WGS sequence

Subcellular locationi

Mitochondrion Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626Mitochondrion Reviewed prediction
Add
BLAST
Chaini27 – 417391Lipoyl synthase, mitochondrialUniRule annotation
PRO_0000398295Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC4JE77.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK03644.
OrthoDBiEOG79KPR7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4JE77-1 [UniParc]FASTAAdd to Basket

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MAVCARGLRC LGTPAVSLRL AASRSYATTT PPDPAIPNTP GAAATSSPAK    50
RPRTSFQDKL NAGPSFSDFL SDKDDARILD PAEAYALKTA LVGPKGKKKE 100
YTRLPPWLKT SIPDSNNYKR IKNDLRGLNL HTVCEEARCP NISECWGGGS 150
KSAATATIML MGDTCTRGCR FCSVKTSKAP PPLDPHEPEN TAEALSRWGL 200
GYVVMTSVDR DDLPDGGARH WAETVMKIKQ KAPNILVECL TGDFDGNLEM 250
VALVAKSGLD VYAHNVETVE ALTPQVRDRR AGFQKSIRVL KAAKAAQPSL 300
ITKTSMMLGL GETEEQMWDA LRQLRAADID VVTFGQYMRP TKRHMPVHEY 350
VRPDVFEFWK EKALEMGFLY CASGPLVRSS YKAGEAFIEN VLKKRRAEST 400
GPGSASVQDV ATGDLVR 417
Length:417
Mass (Da):45,521
Last modified:July 7, 2009 - v1
Checksum:i69CA8F411C8B3B91
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476615 Genomic DNA. Translation: EEP75655.1.
RefSeqiXP_002540988.1. XM_002540942.1.

Genome annotation databases

GeneIDi8437299.
KEGGiure:UREG_00501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476615 Genomic DNA. Translation: EEP75655.1 .
RefSeqi XP_002540988.1. XM_002540942.1.

3D structure databases

ProteinModelPortali C4JE77.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8437299.
KEGGi ure:UREG_00501.

Phylogenomic databases

KOi K03644.
OrthoDBi EOG79KPR7.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UAMH 1704.

Entry informationi

Entry nameiLIPA_UNCRE
AccessioniPrimary (citable) accession number: C4JE77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 7, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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